U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ttc33 tetratricopeptide repeat domain 33 [ Mus musculus (house mouse) ]

Gene ID: 67515, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Ttc33provided by MGI
Official Full Name
tetratricopeptide repeat domain 33provided by MGI
Primary source
MGI:MGI:1914765
See related
Ensembl:ENSMUSG00000022151 AllianceGenome:MGI:1914765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Osrf; 2410099M07Rik; 2900001O04Rik
Summary
Is expressed in central nervous system; dorsal root ganglion; and olfactory epithelium. Orthologous to human TTC33 (tetratricopeptide repeat domain 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 11.6), frontal lobe adult (RPKM 10.5) and 22 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
15 A1; 15 1.99 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (5214971..5247817)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (5185490..5218336)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41256 Neighboring gene STARR-seq mESC enhancer starr_37844 Neighboring gene protein kinase, AMP-activated, alpha 1 catalytic subunit Neighboring gene predicted gene 15938 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2436 Neighboring gene prostaglandin E receptor 4 (subtype EP4) Neighboring gene STARR-seq mESC enhancer starr_37846 Neighboring gene predicted gene, 41257 Neighboring gene ribosomal protein L22 like 1 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tetratricopeptide repeat protein 33
Names
TPR repeat protein 33
osmosis responsive factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355620.1 → NP_001342549.1  tetratricopeptide repeat protein 33

    Status: VALIDATED

    Source sequence(s)
    AC135079
    Consensus CDS
    CCDS27364.1
    UniProtKB/Swiss-Prot
    Q8VIG5, Q9D6K7
    Related
    ENSMUSP00000114033.2, ENSMUST00000118193.8
    Conserved Domains (2) summary
    COG4783
    Location:42 → 164
    YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]
    sd00006
    Location:59 → 87
    TPR; TPR repeat [structural motif]

  2. NM_001355621.1 → NP_001342550.1  tetratricopeptide repeat protein 33

    Status: VALIDATED

    Source sequence(s)
    AC135079
    Consensus CDS
    CCDS27364.1
    UniProtKB/Swiss-Prot
    Q8VIG5, Q9D6K7
    Conserved Domains (2) summary
    COG4783
    Location:42 → 164
    YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]
    sd00006
    Location:59 → 87
    TPR; TPR repeat [structural motif]

  3. NM_026213.3 → NP_080489.1  tetratricopeptide repeat protein 33

    See identical proteins and their annotated locations for NP_080489.1

    Status: VALIDATED

    Source sequence(s)
    AC135079
    Consensus CDS
    CCDS27364.1
    UniProtKB/Swiss-Prot
    Q8VIG5, Q9D6K7
    Related
    ENSMUSP00000022751.9, ENSMUST00000022751.15
    Conserved Domains (2) summary
    COG4783
    Location:42 → 164
    YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]
    sd00006
    Location:59 → 87
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    5214971..5247817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248716.1 → XP_030104576.1  tetratricopeptide repeat protein 33 isoform X1

    UniProtKB/Swiss-Prot
    Q8VIG5, Q9D6K7
    Conserved Domains (2) summary
    COG4783
    Location:42 → 164
    YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]
    sd00006
    Location:59 → 87
    TPR; TPR repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D6K7.1 GenPept UniProtKB/Swiss-Prot:Q9D6K7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous