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Mettl16 methyltransferase 16, N6-methyladenosine [ Mus musculus (house mouse) ]

Gene ID: 67493, updated on 11-Apr-2024

Summary

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Official Symbol
Mettl16provided by MGI
Official Full Name
methyltransferase 16, N6-methyladenosineprovided by MGI
Primary source
MGI:MGI:1914743
See related
Ensembl:ENSMUSG00000010554 AllianceGenome:MGI:1914743
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mett10d; 2610100D03Rik; 2810013M15Rik; A830095F14Rik
Summary
Enables mRNA (N6-adenosine)-methyltransferase activity. Involved in mRNA catabolic process; mRNA destabilization; and mRNA methylation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human METTL16 (methyltransferase 16, N6-methyladenosine). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.5), CNS E18 (RPKM 2.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B5; 11 45.76 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (74661658..74716649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74770815..74826855)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29969 Neighboring gene predicted gene, 24211 Neighboring gene predicted gene, 40198 Neighboring gene STARR-seq mESC enhancer starr_29970 Neighboring gene STARR-seq mESC enhancer starr_29971 Neighboring gene STARR-positive B cell enhancer ABC_E3000 Neighboring gene predicted gene, 57584 Neighboring gene STARR-positive B cell enhancer ABC_E8879 Neighboring gene STARR-positive B cell enhancer ABC_E11484 Neighboring gene STARR-positive B cell enhancer ABC_E7015 Neighboring gene max binding protein Neighboring gene small G protein signaling modulator 2 Neighboring gene microRNA 6926

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Methylation of Structured RNA by the m(6)A Writer METTL16 Is Essential for Mouse Embryonic Development. Mendel M, et al. Mol Cell, 2018 Sep 20. PMID 30197299, Free PMC Article
  2. S-Adenosylmethionine Synthesis Is Regulated by Selective N(6)-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1. Shima H, et al. Cell Rep, 2017 Dec 19. PMID 29262316
  3. The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function. Gehman LT, et al. Genes Dev, 2012 Mar 1. PMID 22357600, Free PMC Article
  4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 23S rRNA (adenine(1618)-N(6))-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA stem-loop binding ISO
Inferred from Sequence Orthology
more info
  
enables U6 snRNA (adenine-(43)-N(6))-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables U6 snRNA 3'-end binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA m(6)A methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA m(6)A methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA methylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of S-adenosylmethionine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of S-adenosylmethionine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA destabilization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in post-transcriptional regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA base methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in regulation of mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in snRNA (adenine-N6)-methylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA N6-adenosine-methyltransferase METTL16
Names
N6-adenosine-methyltransferase METTL16
U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
methyltransferase 10 domain containing
methyltransferase 10 domain-containing protein
methyltransferase like 16
methyltransferase-like protein 16
putative methyltransferase METT10D
NP_080473.1
XP_006534061.1
XP_006534062.1
XP_006534063.1
XP_006534064.1
XP_017170208.1
XP_030102109.1
XP_036012804.1
XP_036012805.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026197.3 → NP_080473.1  RNA N6-adenosine-methyltransferase METTL16

    See identical proteins and their annotated locations for NP_080473.1

    Status: PROVISIONAL

    Source sequence(s)
    AL604066, AL607024
    Consensus CDS
    CCDS25036.1
    UniProtKB/Swiss-Prot
    Q3UMA9, Q9CQG2, Q9D062
    UniProtKB/TrEMBL
    Q5SW15
    Related
    ENSMUSP00000114682.2, ENSMUST00000141755.8
    Conserved Domains (1) summary
    cl17173
    Location:1 → 291
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    74661658..74716649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156911.1 → XP_036012804.1  RNA N6-adenosine-methyltransferase METTL16 isoform X3

    Conserved Domains (1) summary
    cl17173
    Location:1 → 73
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_006533998.5 → XP_006534061.1  RNA N6-adenosine-methyltransferase METTL16 isoform X1

    See identical proteins and their annotated locations for XP_006534061.1

    UniProtKB/Swiss-Prot
    Q3UMA9, Q9CQG2, Q9D062
    UniProtKB/TrEMBL
    Q5SW15
    Conserved Domains (1) summary
    cl17173
    Location:1 → 291
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. XM_006533999.4 → XP_006534062.1  RNA N6-adenosine-methyltransferase METTL16 isoform X1

    See identical proteins and their annotated locations for XP_006534062.1

    UniProtKB/Swiss-Prot
    Q3UMA9, Q9CQG2, Q9D062
    UniProtKB/TrEMBL
    Q5SW15
    Conserved Domains (1) summary
    cl17173
    Location:1 → 291
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  4. XM_017314719.3 → XP_017170208.1  RNA N6-adenosine-methyltransferase METTL16 isoform X2

    UniProtKB/TrEMBL
    Q5SW15
    Conserved Domains (1) summary
    cl17173
    Location:1 → 244
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  5. XM_036156912.1 → XP_036012805.1  RNA N6-adenosine-methyltransferase METTL16 isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:23 → 71
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  6. XM_006534001.4 → XP_006534064.1  RNA N6-adenosine-methyltransferase METTL16 isoform X3

    Conserved Domains (1) summary
    cl17173
    Location:1 → 73
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  7. XM_030246249.2 → XP_030102109.1  RNA N6-adenosine-methyltransferase METTL16 isoform X3

    Conserved Domains (1) summary
    cl17173
    Location:1 → 73
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  8. XM_006534000.5 → XP_006534063.1  RNA N6-adenosine-methyltransferase METTL16 isoform X2

    UniProtKB/TrEMBL
    Q5SW15
    Conserved Domains (1) summary
    cl17173
    Location:1 → 244
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. XR_004937007.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQG2.1 GenPept UniProtKB/Swiss-Prot:Q9CQG2

Gene LinkOut

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