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Zfand4 zinc finger, AN1-type domain 4 [ Mus musculus (house mouse) ]

Gene ID: 67492, updated on 5-Mar-2024

Summary

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Official Symbol
Zfand4provided by MGI
Official Full Name
zinc finger, AN1-type domain 4provided by MGI
Primary source
MGI:MGI:1914742
See related
Ensembl:ENSMUSG00000042213 AllianceGenome:MGI:1914742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Anubl1
Summary
Predicted to enable zinc ion binding activity. Is expressed in bladder; male associated reproductive structure; testis; ureter; and urethra of male. Orthologous to human ZFAND4 (zinc finger AN1-type containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 15.6), liver E18 (RPKM 1.4) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 E3; 6 53.77 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (116241046..116310384)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (116263594..116333423)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9530062K07 gene Neighboring gene WASH complex subunit 2 Neighboring gene predicted gene, 52873 Neighboring gene STARR-positive B cell enhancer ABC_E2799 Neighboring gene STARR-seq mESC enhancer starr_17102 Neighboring gene membrane associated ring-CH-type finger 8 Neighboring gene predicted gene, 23527 Neighboring gene predicted gene, 38880 Neighboring gene arachidonate 5-lipoxygenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  2. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • 2810002D23Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
AN1-type zinc finger protein 4
Names
AN1, ubiquitin-like, homolog
AN1-type zinc finger and ubiquitin domain-containing protein-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290338.1 → NP_001277267.1  AN1-type zinc finger protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001277267.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in its 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 3. The encoded isoform (1) has a shorter N-terminus, compared to isoform 3.
    Source sequence(s)
    AA881170, AC147612, AK012639, BY619467, BY771310, CA465808
    UniProtKB/TrEMBL
    K3W4R9
    Conserved Domains (1) summary
    smart00154
    Location:554 → 592
    ZnF_AN1; AN1-like Zinc finger

  2. NM_001290339.1 → NP_001277268.1  AN1-type zinc finger protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001277268.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 3. The encoded isoform (2) has a shorter N-terminus, compared to isoform 3.
    Source sequence(s)
    AC147612, AK012639, BY619467, CX223310
    Conserved Domains (1) summary
    smart00154
    Location:452 → 490
    ZnF_AN1; AN1-like Zinc finger

  3. NM_001309446.1 → NP_001296375.1  AN1-type zinc finger protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001296375.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC123548, AC147612, AK012639, AV282255, BY771310
    Consensus CDS
    CCDS71818.2
    UniProtKB/Swiss-Prot
    D3Z3C6
    UniProtKB/TrEMBL
    K3W4R9
    Related
    ENSMUSP00000040057.9, ENSMUST00000036503.14
    Conserved Domains (2) summary
    smart00154
    Location:679 → 717
    ZnF_AN1; AN1-like Zinc finger
    cd01802
    Location:54 → 127
    Ubl_ZFAND4; ubiquitin-like (Ubl) domain found in AN1-type zinc finger protein 4 (ZFAND4) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    116241046..116310384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506506.5 → XP_006506569.1  AN1-type zinc finger protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006506569.1

    UniProtKB/Swiss-Prot
    D3Z3C6
    UniProtKB/TrEMBL
    K3W4R9
    Conserved Domains (2) summary
    smart00154
    Location:679 → 717
    ZnF_AN1; AN1-like Zinc finger
    cd01802
    Location:54 → 127
    Ubl_ZFAND4; ubiquitin-like (Ubl) domain found in AN1-type zinc finger protein 4 (ZFAND4) and similar proteins

  2. XM_006506510.5 → XP_006506573.1  AN1-type zinc finger protein 4 isoform X3

    UniProtKB/TrEMBL
    K3W4R9
    Conserved Domains (2) summary
    smart00154
    Location:602 → 640
    ZnF_AN1; AN1-like Zinc finger
    cl28922
    Location:11 → 50
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. XM_030255564.2 → XP_030111424.1  AN1-type zinc finger protein 4 isoform X5

    Conserved Domains (1) summary
    smart00154
    Location:531 → 569
    ZnF_AN1; AN1-like Zinc finger

  4. XM_036152271.1 → XP_036008164.1  AN1-type zinc finger protein 4 isoform X4

    UniProtKB/TrEMBL
    K3W4R9
    Conserved Domains (1) summary
    smart00154
    Location:554 → 592
    ZnF_AN1; AN1-like Zinc finger

  5. XM_006506515.4 → XP_006506578.1  AN1-type zinc finger protein 4 isoform X5

    See identical proteins and their annotated locations for XP_006506578.1

    Conserved Domains (1) summary
    smart00154
    Location:531 → 569
    ZnF_AN1; AN1-like Zinc finger

  6. XM_030255563.2 → XP_030111423.1  AN1-type zinc finger protein 4 isoform X5

    Conserved Domains (1) summary
    smart00154
    Location:531 → 569
    ZnF_AN1; AN1-like Zinc finger

  7. XM_011241443.4 → XP_011239745.1  AN1-type zinc finger protein 4 isoform X6

    Conserved Domains (1) summary
    smart00154
    Location:483 → 521
    ZnF_AN1; AN1-like Zinc finger

  8. XM_011241442.3 → XP_011239744.1  AN1-type zinc finger protein 4 isoform X5

    See identical proteins and their annotated locations for XP_011239744.1

    Conserved Domains (1) summary
    smart00154
    Location:531 → 569
    ZnF_AN1; AN1-like Zinc finger

  9. XM_006506508.5 → XP_006506571.1  AN1-type zinc finger protein 4 isoform X2

    UniProtKB/TrEMBL
    K3W4R9
    Conserved Domains (2) summary
    smart00154
    Location:631 → 669
    ZnF_AN1; AN1-like Zinc finger
    cl28922
    Location:54 → 90
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  10. XM_011241444.4 → XP_011239746.1  AN1-type zinc finger protein 4 isoform X7

    See identical proteins and their annotated locations for XP_011239746.1

    Conserved Domains (1) summary
    smart00154
    Location:452 → 490
    ZnF_AN1; AN1-like Zinc finger

  11. XM_030255562.1 → XP_030111422.1  AN1-type zinc finger protein 4 isoform X4

    UniProtKB/TrEMBL
    K3W4R9
    Conserved Domains (1) summary
    smart00154
    Location:554 → 592
    ZnF_AN1; AN1-like Zinc finger

  12. XM_006506507.5 → XP_006506570.1  AN1-type zinc finger protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006506570.1

    UniProtKB/Swiss-Prot
    D3Z3C6
    UniProtKB/TrEMBL
    K3W4R9
    Conserved Domains (2) summary
    smart00154
    Location:679 → 717
    ZnF_AN1; AN1-like Zinc finger
    cd01802
    Location:54 → 127
    Ubl_ZFAND4; ubiquitin-like (Ubl) domain found in AN1-type zinc finger protein 4 (ZFAND4) and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081317.1: Suppressed sequence

    Description
    NM_001081317.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3Z3C6.2 GenPept UniProtKB/Swiss-Prot:D3Z3C6

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