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Nek10 NIMA (never in mitosis gene a)- related kinase 10 [ Mus musculus (house mouse) ]

Gene ID: 674895, updated on 21-Apr-2024

Summary

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Official Symbol
Nek10provided by MGI
Official Full Name
NIMA (never in mitosis gene a)- related kinase 10provided by MGI
Primary source
MGI:MGI:2685128
See related
Ensembl:ENSMUSG00000042567 AllianceGenome:MGI:2685128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm282
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including mucociliary clearance; positive regulation of protein phosphorylation; and regulation of ERK1 and ERK2 cascade. Predicted to act upstream of or within phosphorylation. Predicted to be part of protein kinase complex. Is expressed in brain and female reproductive system. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 44. Orthologous to human NEK10 (NIMA related kinase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
14 A1; 14 7.08 cM
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (7457704..7666183, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (14803580..15012059)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31517 Neighboring gene STARR-seq mESC enhancer starr_36001 Neighboring gene predicted gene, 18142 Neighboring gene predicted gene, 46441 Neighboring gene STARR-seq mESC enhancer starr_36000 Neighboring gene STARR-seq mESC enhancer starr_35999 Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter, member 7 Neighboring gene STARR-seq mESC enhancer starr_35997 Neighboring gene STARR-positive B cell enhancer ABC_E749 Neighboring gene predicted gene, 52165

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation. Moniz LS, et al. Mol Cell Biol, 2011 Jan. PMID 20956560, Free PMC Article
  2. The chromatin regulator Brpf1 regulates embryo development and cell proliferation. You L, et al. J Biol Chem, 2015 May 1. PMID 25773539, Free PMC Article
  3. Lineage-specific biology revealed by a finished genome assembly of the mouse. Church DM, et al. PLoS Biol, 2009 May 5. PMID 19468303, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mucociliary clearance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle G2/M phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle G2/M phase transition ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of protein kinase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek10
Names
never in mitosis A-related kinase 10
nimA-related protein kinase 10
NP_001182158.1
NP_001381921.1
XP_006518155.1
XP_006518159.1
XP_011243073.1
XP_017171654.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195229.2 → NP_001182158.1  serine/threonine-protein kinase Nek10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117608, AC129580
    Consensus CDS
    CCDS56937.1
    UniProtKB/Swiss-Prot
    Q3UGM2
    UniProtKB/TrEMBL
    K3W4R8
    Related
    ENSMUSP00000153142.2, ENSMUST00000224491.2
    Conserved Domains (2) summary
    smart00220
    Location:519 → 779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518 → 785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  2. NM_001394992.1 → NP_001381921.1  serine/threonine-protein kinase Nek10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117608, AC129580
    UniProtKB/Swiss-Prot
    Q3UGM2
    Related
    ENSMUSP00000108250.3, ENSMUST00000112631.9
    Conserved Domains (1) summary
    cd08528
    Location:518 → 785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    7457704..7666183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518092.2 → XP_006518155.1  serine/threonine-protein kinase Nek10 isoform X1

    See identical proteins and their annotated locations for XP_006518155.1

    UniProtKB/Swiss-Prot
    Q3UGM2
    Conserved Domains (1) summary
    cd08528
    Location:518 → 785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  2. XM_011244771.1 → XP_011243073.1  serine/threonine-protein kinase Nek10 isoform X1

    See identical proteins and their annotated locations for XP_011243073.1

    UniProtKB/Swiss-Prot
    Q3UGM2
    Conserved Domains (1) summary
    cd08528
    Location:518 → 785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

  3. XM_017316165.1 → XP_017171654.1  serine/threonine-protein kinase Nek10 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:19 → 106
    PKc_like; Protein Kinases, catalytic domain

  4. XM_006518096.5 → XP_006518159.1  serine/threonine-protein kinase Nek10 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:518 → 672
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_382965.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001034865.3: Suppressed sequence

    Description
    NM_001034865.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UGM2.2 GenPept UniProtKB/Swiss-Prot:Q3UGM2

Gene LinkOut

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