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Mtfr1 mitochondrial fission regulator 1 [ Mus musculus (house mouse) ]

Gene ID: 67472, updated on 2-Apr-2024

Summary

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Official Symbol
Mtfr1provided by MGI
Official Full Name
mitochondrial fission regulator 1provided by MGI
Primary source
MGI:MGI:1914722
See related
Ensembl:ENSMUSG00000027601 AllianceGenome:MGI:1914722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Chppr; Fam54a2; 1300002C08Rik; 1700080D04Rik; 2810026O10Rik; 4930579E05Rik
Summary
Involved in aerobic respiration. Located in mitochondrion. Is expressed in brain; embryo; and testis. Orthologous to human MTFR1 (mitochondrial fission regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 71.8), liver E14 (RPKM 19.6) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 A2; 3 5.36 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (19241481..19274981)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (19187315..19220817)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07084 Neighboring gene predicted gene, 30341 Neighboring gene STARR-seq mESC enhancer starr_07085 Neighboring gene STARR-seq mESC enhancer starr_07087 Neighboring gene STARR-positive B cell enhancer ABC_E334 Neighboring gene STARR-positive B cell enhancer ABC_E3427 Neighboring gene armadillo repeat containing 1 Neighboring gene STARR-seq mESC enhancer starr_07090 Neighboring gene STARR-seq mESC enhancer starr_07091 Neighboring gene phosphodiesterase 7A Neighboring gene RIKEN cDNA 3110037C07 gene Neighboring gene STARR-positive B cell enhancer mm9_chr3:19250042-19250343 Neighboring gene predicted gene, 52602

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NFAT4-dependent miR-324-5p regulates mitochondrial morphology and cardiomyocyte cell death by targeting Mtfr1. Wang K, et al. Cell Death Dis, 2015 Dec 3. PMID 26633713, Free PMC Article
  2. Impaired expression of genes coding for reactive oxygen species scavenging enzymes in testes of Mtfr1/Chppr-deficient mice. Monticone M, et al. Reproduction, 2007 Sep. PMID 17709566
  3. Chondrocyte protein with a poly-proline region (CHPPR) is a novel mitochondrial protein and promotes mitochondrial fission. Tonachini L, et al. J Cell Physiol, 2004 Dec. PMID 15389597
  4. The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respiration. Monticone M, et al. J Cell Physiol, 2010 Nov. PMID 20568109
  5. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study defines the NFAT4/ miR-324-5p/Mtfr1 axis, which participates in the regulation of mitochondrial fission and cardiomyocyte apoptosis.
    Title: NFAT4-dependent miR-324-5p regulates mitochondrial morphology and cardiomyocyte cell death by targeting Mtfr1.
  2. The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respiration and may affect male fertility.
    Title: The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respiration.
  3. CHPPR is able to promote mitochondrial fission with a sequence specific mechanism suggesting that this event may be relevant to late stage of chondrocyte differentiation [CHPPR]
    Title: Chondrocyte protein with a poly-proline region (CHPPR) is a novel mitochondrial protein and promotes mitochondrial fission.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial fission regulator 1
Names
chondrocyte protein with a poly-proline region

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253390.3 → NP_001240319.1  mitochondrial fission regulator 1

    See identical proteins and their annotated locations for NP_001240319.1

    Status: VALIDATED

    Source sequence(s)
    AC127283
    Consensus CDS
    CCDS17256.1
    UniProtKB/Swiss-Prot
    Q99MB2, Q9CQZ4
    UniProtKB/TrEMBL
    Q3TTQ5, Q8CGA8
    Related
    ENSMUSP00000112752.2, ENSMUST00000119865.8
    Conserved Domains (1) summary
    pfam05308
    Location:24 → 249
    Mito_fiss_reg; Mitochondrial fission regulator

  2. NM_001253391.3 → NP_001240320.1  mitochondrial fission regulator 1

    See identical proteins and their annotated locations for NP_001240320.1

    Status: VALIDATED

    Source sequence(s)
    AC127283
    Consensus CDS
    CCDS17256.1
    UniProtKB/Swiss-Prot
    Q99MB2, Q9CQZ4
    UniProtKB/TrEMBL
    Q3TTQ5, Q8CGA8
    Related
    ENSMUSP00000112824.2, ENSMUST00000117529.8
    Conserved Domains (1) summary
    pfam05308
    Location:24 → 249
    Mito_fiss_reg; Mitochondrial fission regulator

  3. NM_001356295.2 → NP_001343224.1  mitochondrial fission regulator 1

    Status: VALIDATED

    Source sequence(s)
    AC127283
    Consensus CDS
    CCDS17256.1
    UniProtKB/Swiss-Prot
    Q99MB2, Q9CQZ4
    UniProtKB/TrEMBL
    Q3TTQ5, Q8CGA8
    Conserved Domains (1) summary
    pfam05308
    Location:24 → 249
    Mito_fiss_reg; Mitochondrial fission regulator

  4. NM_001428962.1 → NP_001415891.1  mitochondrial fission regulator 1

    Status: VALIDATED

    Source sequence(s)
    AC127283

  5. NM_026182.7 → NP_080458.1  mitochondrial fission regulator 1

    See identical proteins and their annotated locations for NP_080458.1

    Status: VALIDATED

    Source sequence(s)
    AC127283
    Consensus CDS
    CCDS17256.1
    UniProtKB/Swiss-Prot
    Q99MB2, Q9CQZ4
    UniProtKB/TrEMBL
    Q3TTQ5, Q8CGA8
    Related
    ENSMUSP00000119724.2, ENSMUST00000130645.8
    Conserved Domains (1) summary
    pfam05308
    Location:24 → 249
    Mito_fiss_reg; Mitochondrial fission regulator

RNA

  1. NR_045575.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127283

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    19241481..19274981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249708.4 → XP_011248010.1  mitochondrial fission regulator 1 isoform X1

    UniProtKB/Swiss-Prot
    Q99MB2, Q9CQZ4
    UniProtKB/TrEMBL
    Q3TTQ5, Q8CGA8
    Conserved Domains (1) summary
    pfam05308
    Location:24 → 249
    Mito_fiss_reg; Mitochondrial fission regulator

  2. XM_036163244.1 → XP_036019137.1  mitochondrial fission regulator 1 isoform X2

    Conserved Domains (1) summary
    pfam05308
    Location:24 → 249
    Mito_fiss_reg; Mitochondrial fission regulator
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MB2.1 GenPept UniProtKB/Swiss-Prot:Q99MB2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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