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SSR3 signal sequence receptor subunit 3 [ Homo sapiens (human) ]

Gene ID: 6747, updated on 5-Mar-2024

Summary

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Official Symbol
SSR3provided by HGNC
Official Full Name
signal sequence receptor subunit 3provided by HGNC
Primary source
HGNC:HGNC:11325
See related
Ensembl:ENSG00000114850 MIM:606213; AllianceGenome:HGNC:11325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRAPG
Summary
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in thyroid (RPKM 48.0), endometrium (RPKM 38.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
3q25.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (156539553..156555117, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (159314207..159329772, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (156257342..156272906, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 1 Neighboring gene uncharacterized LOC124906298 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:156174295-156175494 Neighboring gene KCNAB1 antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:156180752-156181363 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:156200851-156202050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:156251527-156252026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20729 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14838 Neighboring gene TIPARP antisense RNA 1 Neighboring gene TCDD inducible poly(ADP-ribose) polymerase Neighboring gene methyltransferase like 15 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma. Dmello C, et al. Clin Cancer Res, 2022 Jul 15. PMID 35552677, Free PMC Article
  2. The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum. Xu X, et al. Diabetes, 2022 Mar 1. PMID 34857543, Free PMC Article
  3. TRAPγ-CDG shows asymmetric glycosylation and an effect on processing of proteins required in higher organisms. Dittner-Moormann S, et al. J Med Genet, 2021 Mar. PMID 32332102
  4. Mutations in the translocon-associated protein complex subunit SSR3 cause a novel congenital disorder of glycosylation. Ng BG, et al. J Inherit Metab Dis, 2019 Sep. PMID 30945312, Free PMC Article
  5. Overexpression of signal sequence receptor γ predicts poor survival in patients with hepatocellular carcinoma. Huang S, et al. Hum Pathol, 2018 Nov. PMID 29940286

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Signal sequence receptor subunit 3: A novel indicator of immunosuppressive tumor microenvironment and clinical benefits from immunotherapy.
    Title: Signal sequence receptor subunit 3: A novel indicator of immunosuppressive tumor microenvironment and clinical benefits from immunotherapy.
  2. Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma.
    Title: Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma.
  3. The Role of TRAPgamma/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum.
    Title: The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum.
  4. TRAPgamma-CDG shows asymmetric glycosylation and an effect on processing of proteins required in higher organisms.
    Title: TRAPγ-CDG shows asymmetric glycosylation and an effect on processing of proteins required in higher organisms.
  5. Mutations in the translocon-associated protein complex subunit SSR3 cause a novel congenital disorder of glycosylation.
    Title: Mutations in the translocon-associated protein complex subunit SSR3 cause a novel congenital disorder of glycosylation.
  6. SSR3 acts as an oncogene in hepatocellular carcinoma with overexpression predicting poor survival.
    Title: Overexpression of signal sequence receptor γ predicts poor survival in patients with hepatocellular carcinoma.
  7. Data suggest that the mutation leads to complete absence of TRAP gamma (SSR3).
    Title: Dissecting the molecular organization of the translocon-associated protein complex.
  8. translocon-associated protein subunit gamma (TRAPgamma) was identified as a novel TR3 binding partner.
    Title: The orphan nuclear receptor TR3/Nur77 regulates ER stress and induces apoptosis via interaction with TRAPγ.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of signal sequence receptor, gamma (translocon-associated protein gamma; SSR3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides upregulate gene expression of signal sequence receptor, gamma (translocon-associated protein gamma; SSR3) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
translocon-associated protein subunit gamma
Names
SSR gamma
TRAP-complex gamma subunit
TRAP-gamma
signal sequence receptor subunit gamma
signal sequence receptor, gamma (translocon-associated protein gamma)
translocon-associated protein gamma subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308197.2 → NP_001295126.1  translocon-associated protein subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_001295126.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC092927, AI225105, AK304364, HY035536
    Consensus CDS
    CCDS77846.1
    UniProtKB/TrEMBL
    C9JA28
    Related
    ENSP00000420641.1, ENST00000467789.5
    Conserved Domains (1) summary
    pfam07074
    Location:12 → 196
    TRAP-gamma; Translocon-associated protein, gamma subunit (TRAP-gamma)

  2. NM_001308204.2 → NP_001295133.1  translocon-associated protein subunit gamma isoform 3

    See identical proteins and their annotated locations for NP_001295133.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a 5' exon, contains an alternate 5' terminal exon, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. It encodes isoform 3 which is shorter compared to isoform 1. Both variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AC092927, AF110647, AI225105, BC017203, BJ997360, BM988383, BU532041, CN409041, CX786292, DA283706
    Consensus CDS
    CCDS82865.1
    UniProtKB/TrEMBL
    C9J365
    Related
    ENSP00000417306.1, ENST00000463503.5
    Conserved Domains (1) summary
    pfam07074
    Location:1 → 131
    TRAP-gamma; Translocon-associated protein, gamma subunit (TRAP-gamma)

  3. NM_001308205.2 → NP_001295134.1  translocon-associated protein subunit gamma isoform 3

    See identical proteins and their annotated locations for NP_001295134.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a 5' exon, contains an alternate 5' terminal exon, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. It encodes isoform 3 which is shorter compared to isoform 1. Both variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AC092927, AF110647, AI225105, BC017203, BJ997360, BM988383, BU532041, CN409041, CX786292, DA725890
    Consensus CDS
    CCDS82865.1
    UniProtKB/TrEMBL
    C9J365
    Related
    ENSP00000420087.1, ENST00000496050.1
    Conserved Domains (1) summary
    pfam07074
    Location:1 → 131
    TRAP-gamma; Translocon-associated protein, gamma subunit (TRAP-gamma)

  4. NM_007107.5 → NP_009038.1  translocon-associated protein subunit gamma isoform 2

    See identical proteins and their annotated locations for NP_009038.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AC092927, AF110647, AI225105, BC017203, BJ997360, BM988383, BU532041, CN409041, CX786292, DA750309
    Consensus CDS
    CCDS3176.1
    UniProtKB/Swiss-Prot
    B2R7D0, B4E2P2, D3DNK5, Q549M4, Q9UNL2
    UniProtKB/TrEMBL
    C9JA28
    Related
    ENSP00000265044.2, ENST00000265044.7
    Conserved Domains (1) summary
    pfam07074
    Location:12 → 183
    TRAP-gamma; Translocon-associated protein, gamma subunit (TRAP-gamma)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    156539553..156555117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    159314207..159329772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UNL2.1 GenPept UniProtKB/Swiss-Prot:Q9UNL2

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