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Mmd monocyte to macrophage differentiation-associated [ Mus musculus (house mouse) ]

Gene ID: 67468, updated on 5-Mar-2024

Summary

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Official Symbol
Mmdprovided by MGI
Official Full Name
monocyte to macrophage differentiation-associatedprovided by MGI
Primary source
MGI:MGI:1914718
See related
Ensembl:ENSMUSG00000003948 AllianceGenome:MGI:1914718
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Paqr11; 1200017E07Rik; 1810073C06Rik
Summary
Predicted to enable protein kinase activity. Predicted to be involved in positive regulation of neuron differentiation; positive regulation of protein kinase activity; and regulation of protein localization. Predicted to be located in Golgi apparatus. Is expressed in several structures, including alimentary system; cranial ganglion; musculoskeletal system; nose; and retina. Orthologous to human MMD (monocyte to macrophage differentiation associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 114.9), genital fat pad adult (RPKM 66.5) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 C; 11 54.89 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (90078513..90169399)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (90249276..90278573)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34726 Neighboring gene predicted gene 11494 Neighboring gene STARR-seq mESC enhancer starr_30411 Neighboring gene small integral membrane protein 36 Neighboring gene predicted gene, 42089 Neighboring gene STARR-positive B cell enhancer ABC_E5266 Neighboring gene hepatic leukemia factor Neighboring gene STARR-seq mESC enhancer starr_30412 Neighboring gene predicted gene, 34850

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PAQR11 modulates monocyte-to-macrophage differentiation and pathogenesis of rheumatoid arthritis. Lin Y, et al. Immunology, 2021 May. PMID 33421113, Free PMC Article
  2. Genome-Wide Off-Target Analysis in CRISPR-Cas9 Modified Mice and Their Offspring. Dong Y, et al. G3 (Bethesda), 2019 Nov 5. PMID 31492696, Free PMC Article
  3. Monocyte to macrophage differentiation-associated (MMD) positively regulates ERK and Akt activation and TNF-α and NO production in macrophages. Liu Q, et al. Mol Biol Rep, 2012 May. PMID 22203480
  4. Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D. Huang M, et al. Mol Metab, 2021 May. PMID 33549845, Free PMC Article
  5. Pancreatic expression and mitochondrial localization of the progestin-adipoQ receptor PAQR10. Góñez LJ, et al. Mol Med, 2008 Nov-Dec. PMID 18769639, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D.
    Title: Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D.
  2. PAQR11 modulates monocyte-to-macrophage differentiation and pathogenesis of rheumatoid arthritis.
    Title: PAQR11 modulates monocyte-to-macrophage differentiation and pathogenesis of rheumatoid arthritis.
  3. These results suggested that MMD modulates TNF-alpha and NO production in macrophages, and this process might involves Erk or Akt.
    Title: Monocyte to macrophage differentiation-associated (MMD) positively regulates ERK and Akt activation and TNF-α and NO production in macrophages.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
monocyte to macrophage differentiation factor
Names
monocyte to macrophage differentiation protein
progestin and adipoQ receptor family member 11
progestin and adipoQ receptor family member XI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395423.1 → NP_001382352.1  monocyte to macrophage differentiation factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626785, AL645990
    UniProtKB/TrEMBL
    Q3UE73
    Conserved Domains (1) summary
    TIGR01065
    Location:28 → 228
    hlyIII; channel protein, hemolysin III family

  2. NM_026178.2 → NP_080454.1  monocyte to macrophage differentiation factor isoform 1

    See identical proteins and their annotated locations for NP_080454.1

    Status: VALIDATED

    Source sequence(s)
    BC021914
    Consensus CDS
    CCDS25240.1
    UniProtKB/Swiss-Prot
    Q3TAU1, Q5SVU7, Q9CQY7
    UniProtKB/TrEMBL
    Q3UE73
    Related
    ENSMUSP00000004050.7, ENSMUST00000004050.7
    Conserved Domains (1) summary
    TIGR01065
    Location:27 → 227
    hlyIII; channel protein, hemolysin III family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    90078513..90169399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQY7.1 GenPept UniProtKB/Swiss-Prot:Q9CQY7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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