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Nvl nuclear VCP-like [ Mus musculus (house mouse) ]

Gene ID: 67459, updated on 11-Apr-2024

Summary

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Official Symbol
Nvlprovided by MGI
Official Full Name
nuclear VCP-likeprovided by MGI
Primary source
MGI:MGI:1914709
See related
Ensembl:ENSMUSG00000026516 AllianceGenome:MGI:1914709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200009I24Rik
Summary
Predicted to enable ATP binding activity; ATP hydrolysis activity; and preribosome binding activity. Predicted to be involved in several processes, including positive regulation of telomerase activity; regulation of protein localization to nucleolus; and ribosome biogenesis. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of nuclear exosome (RNase complex) and telomerase holoenzyme complex. Predicted to be active in nucleus. Orthologous to human NVL (nuclear VCP like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 9.1), CNS E14 (RPKM 8.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nvl in Genome Data Viewer
Location:
1 H4; 1 84.53 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (180914703..180974557, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (181087138..181144214, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 37406 Neighboring gene degenerative spermatocyte homolog 1 pseudogene Neighboring gene fibroblast growth factor receptor 3, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2593 Neighboring gene STARR-positive B cell enhancer ABC_E2026 Neighboring gene cornichon family AMPA receptor auxiliary protein 4 Neighboring gene WD repeat domain 26 Neighboring gene predicted gene, 50602

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1/WDR74 Important for Localization and Interaction with Rix7/NVL2. Lo YH, et al. Structure, 2017 May 2. PMID 28416111, Free PMC Article
  2. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article
  3. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. Valdez-Sinon AN, et al. iScience, 2020 May 22. PMID 32434143, Free PMC Article
  4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables preribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables preribosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization to nucleolus ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal large subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome biogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of nuclear exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of telomerase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear valosin-containing protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026171.2 → NP_080447.1  nuclear valosin-containing protein-like

    See identical proteins and their annotated locations for NP_080447.1

    Status: VALIDATED

    Source sequence(s)
    AC119911, AK140509, BY793394
    Consensus CDS
    CCDS15581.1
    UniProtKB/Swiss-Prot
    Q3USC4, Q8BW27, Q8K2B5, Q9DBY8
    Related
    ENSMUSP00000027797.8, ENSMUST00000027797.9
    Conserved Domains (3) summary
    COG0464
    Location:283 → 842
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam00004
    Location:617 → 747
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam16725
    Location:2 → 72
    Nucleolin_bd; Nucleolin binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    180914703..180974557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496964.4 → XP_006497027.1  nuclear valosin-containing protein-like isoform X2

    Conserved Domains (1) summary
    TIGR01243
    Location:137 → 750
    CDC48; AAA family ATPase, CDC48 subfamily

  2. XM_011238856.3 → XP_011237158.1  nuclear valosin-containing protein-like isoform X1

    Conserved Domains (2) summary
    TIGR01243
    Location:220 → 833
    CDC48; AAA family ATPase, CDC48 subfamily
    pfam16725
    Location:24 → 50
    Nucleolin_bd; Nucleolin binding domain

  3. XM_030242438.2 → XP_030098298.1  nuclear valosin-containing protein-like isoform X3

    Conserved Domains (1) summary
    TIGR01243
    Location:125 → 738
    CDC48; AAA family ATPase, CDC48 subfamily

  4. XM_011238857.4 → XP_011237159.1  nuclear valosin-containing protein-like isoform X3

    Conserved Domains (1) summary
    TIGR01243
    Location:125 → 738
    CDC48; AAA family ATPase, CDC48 subfamily

  5. XM_036153140.1 → XP_036009033.1  nuclear valosin-containing protein-like isoform X2

    Conserved Domains (1) summary
    TIGR01243
    Location:137 → 750
    CDC48; AAA family ATPase, CDC48 subfamily

  6. XM_036153141.1 → XP_036009034.1  nuclear valosin-containing protein-like isoform X3

    Conserved Domains (1) summary
    TIGR01243
    Location:125 → 738
    CDC48; AAA family ATPase, CDC48 subfamily

RNA

  1. XR_004934115.1 RNA Sequence

  2. XR_003946443.2 RNA Sequence

  3. XR_373614.5 RNA Sequence

  4. XR_003946442.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBY8.1 GenPept UniProtKB/Swiss-Prot:Q9DBY8

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