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Ikbip IKBKB interacting protein [ Mus musculus (house mouse) ]

Gene ID: 67454, updated on 5-Mar-2024

Summary

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Official Symbol
Ikbipprovided by MGI
Official Full Name
IKBKB interacting proteinprovided by MGI
Primary source
MGI:MGI:1914704
See related
Ensembl:ENSMUSG00000019975 AllianceGenome:MGI:1914704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ikip; 1200009F10Rik; 1700023M03Rik
Summary
Predicted to be located in endoplasmic reticulum. Is expressed in mandible; maxilla; and rib. Orthologous to human IKBIP (IKBKB interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 5.6), limb E14.5 (RPKM 5.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C2; 10 45.54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (90918667..90938475)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (91082737..91102613)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and sterile alpha motif domain containing 1B Neighboring gene STARR-seq mESC enhancer starr_27538 Neighboring gene predicted gene, 53598 Neighboring gene STARR-positive B cell enhancer ABC_E9131 Neighboring gene predicted gene, 25390 Neighboring gene apoptotic peptidase activating factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E370 Neighboring gene STARR-positive B cell enhancer ABC_E6900 Neighboring gene STARR-positive B cell enhancer ABC_E5165 Neighboring gene STARR-seq mESC enhancer starr_27543 Neighboring gene STARR-seq mESC enhancer starr_27545 Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 Neighboring gene predicted gene, 24119 Neighboring gene nuclear encoded tRNA trytophan 2 (anticodon CCA) Neighboring gene thymopoietin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IKIP Negatively Regulates NF-κB Activation and Inflammation through Inhibition of IKKα/β Phosphorylation. Wu H, et al. J Immunol, 2020 Jan 15. PMID 31826938
  2. A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53. Hofer-Warbinek R, et al. Cell Death Differ, 2004 Dec. PMID 15389287
  3. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inhibitor of nuclear factor kappa-B kinase-interacting protein
Names
IKK-interacting protein
i kappa-B kinase-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026166.2 → NP_080442.2  inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC140410, BY277133, CF171082
    Consensus CDS
    CCDS36031.1
    UniProtKB/Swiss-Prot
    Q7TMH1, Q8K1Z4, Q9DA09, Q9DBZ1
    UniProtKB/TrEMBL
    E9QMH7
    Related
    ENSMUSP00000020149.6, ENSMUST00000020149.6
    Conserved Domains (1) summary
    COG1196
    Location:64 → 349
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_027078.2 → NP_081354.1  inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_081354.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 3' terminal exon, which results in a distinct 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK006283, BC034890, BY277133
    Consensus CDS
    CCDS24119.1
    UniProtKB/Swiss-Prot
    Q9DBZ1
    Related
    ENSMUSP00000020150.4, ENSMUST00000020150.10
    Conserved Domains (1) summary
    COG1196
    Location:71 → 342
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    90918667..90938475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314068.3 → XP_017169557.1  inhibitor of nuclear factor kappa-B kinase-interacting protein isoform X1

    UniProtKB/Swiss-Prot
    Q7TMH1, Q8K1Z4, Q9DA09, Q9DBZ1
    Conserved Domains (1) summary
    COG1196
    Location:59 → 326
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. XR_001779582.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBZ1.2 GenPept UniProtKB/Swiss-Prot:Q9DBZ1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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