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Hoga1 4-hydroxy-2-oxoglutarate aldolase 1 [ Mus musculus (house mouse) ]

Gene ID: 67432, updated on 21-Apr-2024

Summary

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Official Symbol
Hoga1provided by MGI
Official Full Name
4-hydroxy-2-oxoglutarate aldolase 1provided by MGI
Primary source
MGI:MGI:1914682
See related
Ensembl:ENSMUSG00000025176 AllianceGenome:MGI:1914682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Npl2; Dhdpsl; 0610010D20Rik
Summary
Predicted to enable 4-hydroxy-2-oxoglutarate aldolase activity and protein homodimerization activity. Predicted to be involved in carboxylic acid metabolic process. Located in mitochondrion. Used to study primary hyperoxaluria. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 3. Orthologous to human HOGA1 (4-hydroxy-2-oxoglutarate aldolase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 87.7), kidney adult (RPKM 62.5) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C3; 19 35.67 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (42033998..42060128)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (42045559..42071689)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ubiquitin domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_46168 Neighboring gene STARR-seq mESC enhancer starr_46171 Neighboring gene ankyrin repeat domain 2 Neighboring gene RIKEN cDNA 4933411K16 gene Neighboring gene MORN repeat containing 4 Neighboring gene STARR-seq mESC enhancer starr_46172 Neighboring gene STARR-positive B cell enhancer ABC_E781 Neighboring gene STARR-seq mESC enhancer starr_46173 Neighboring gene phosphatidylinositol 4-kinase type 2 alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hydroxyproline metabolism in a mouse model of Primary Hyperoxaluria Type 3. Li X, et al. Biochim Biophys Acta, 2015 Dec. PMID 26428388, Free PMC Article
  2. In vivo CRISPR-Cas9 inhibition of hepatic LDH as treatment of primary hyperoxaluria. Martinez-Turrillas R, et al. Mol Ther Methods Clin Dev, 2022 Jun 9. PMID 35402636, Free PMC Article
  3. Differences in health status affect susceptibility and mapping of genetic loci for atherosclerosis (fatty streak) in inbred mice. Srivastava U, et al. Arterioscler Thromb Vasc Biol, 2012 Oct. PMID 22837474, Free PMC Article
  4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4-hydroxy-2-oxoglutarate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4-hydroxy-2-oxoglutarate aldolase activity ISO
Inferred from Sequence Orthology
more info
  
enables N-acetylneuraminate lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 4-hydroxyproline catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in N-acetylneuraminate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glyoxylate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glyoxylate catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glyoxylate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in oxalate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in pyruvate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
4-hydroxy-2-oxoglutarate aldolase, mitochondrial
Names
DHDPS-like protein
N-acetylneuraminate pyruvate lyase 2 (putative)
dihydrodipicolinate synthase-like, mitochondrial
probable 2-keto-4-hydroxyglutarate aldolase
probable KHG-aldolase
NP_080428.1
XP_030106914.1
XP_030106915.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026152.2 → NP_080428.1  4-hydroxy-2-oxoglutarate aldolase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_080428.1

    Status: VALIDATED

    Source sequence(s)
    AC133503, AK002457
    Consensus CDS
    CCDS29820.1
    UniProtKB/Swiss-Prot
    Q91W74, Q9CY60, Q9DCU9
    Related
    ENSMUSP00000080414.5, ENSMUST00000081714.5
    Conserved Domains (1) summary
    cd00408
    Location:32 → 312
    DHDPS-like; Dihydrodipicolinate synthase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    42033998..42060128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251054.1 → XP_030106914.1  4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1

    Conserved Domains (1) summary
    cd00408
    Location:6 → 198
    DHDPS-like; Dihydrodipicolinate synthase family

  2. XM_030251055.1 → XP_030106915.1  4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1

    Conserved Domains (1) summary
    cd00408
    Location:6 → 198
    DHDPS-like; Dihydrodipicolinate synthase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCU9.1 GenPept UniProtKB/Swiss-Prot:Q9DCU9

Gene LinkOut

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