Nudcd1 NudC domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nudcd1provided by MGI
Official Full Name: NudC domain containing 1provided by MGI
Primary source: MGI:MGI:1914679
See related: Ensembl:ENSMUSG00000038736 AllianceGenome:MGI:1914679
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cml66; CML66-L; 4921532K09Rik
Summary: Predicted to be located in cytosol and nucleoplasm. Is expressed in telencephalon. Orthologous to human NUDCD1 (NudC domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 10.6), liver E14 (RPKM 7.4) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.2; 15 16.91 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (44238623..44291703, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (44375227..44428307, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results indicate that OVA66 is important in oncogenic transformation, promoting proliferation, cell migration and reducing apoptosis via hyperactivating PI3K/AKT and ERK1/2 MAPK signaling pathway.
Title: OVA66, a tumor associated protein, induces oncogenic transformation of NIH3T3 cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW260430 (e-PCR)
- UniSTS:180752

AW556235 (e-PCR)
- UniSTS:180753

RH124580 (e-PCR)
- UniSTS:161402

RH125663 (e-PCR)
- UniSTS:162447

NoName (e-PCR)
- UniSTS:237294

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nudC domain-containing protein 1

Names: chronic myelogenous leukemia tumor antigen 66

NP_001107026.1

EC 2.3.2.27

NP_080425.3

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113554.1 → NP_001107026.1 nudC domain-containing protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate splice site in the coding region, as compared to variant 1. The resulting isoform (2) lacks an internal amino acid, as compared to isoform 1.

Source sequence(s)

AC127312, AF521132, AK083587

Consensus CDS

CCDS88761.1

UniProtKB/TrEMBL

A0A2K6EDK3

Related

ENSMUSP00000042746.8, ENSMUST00000038719.8

Conserved Domains (1) summary

cl00175
Location:276 → 359

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
NM_026149.4 → NP_080425.3 nudC domain-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_080425.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC127312, AK014996, AK077673, AK083587

Consensus CDS

CCDS27455.1

UniProtKB/Swiss-Prot

Q3THV3, Q6PIP5, Q71EC1, Q8BJZ5

Related

ENSMUSP00000154478.2, ENSMUST00000227843.2

Conserved Domains (1) summary

cl00175
Location:277 → 360

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.