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Far1 fatty acyl CoA reductase 1 [ Mus musculus (house mouse) ]

Gene ID: 67420, updated on 5-Mar-2024

Summary

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Official Symbol
Far1provided by MGI
Official Full Name
fatty acyl CoA reductase 1provided by MGI
Primary source
MGI:MGI:1914670
See related
Ensembl:ENSMUSG00000030759 AllianceGenome:MGI:1914670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mlstd2; 2600011M19Rik; 2900034E22Rik; 3732409C05Rik
Summary
Enables fatty-acyl-CoA reductase (alcohol-forming) activity. Involved in wax biosynthetic process. Located in peroxisome. Orthologous to human FAR1 (fatty acyl-CoA reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 22.8), CNS E18 (RPKM 14.0) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Far1 in Genome Data Viewer
Location:
7 F1; 7 59.21 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (113113008..113170713)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (113513719..113571506)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene parathyroid hormone Neighboring gene STARR-seq mESC enhancer starr_19909 Neighboring gene STARR-positive B cell enhancer mm9_chr7:120611773-120612073 Neighboring gene BCL2-associated transcription factor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_19911 Neighboring gene STARR-positive B cell enhancer ABC_E1355 Neighboring gene STARR-positive B cell enhancer ABC_E10465 Neighboring gene fatty acyl CoA reductase 1, opposite strand Neighboring gene predicted gene, 33828 Neighboring gene STARR-seq mESC enhancer starr_19913 Neighboring gene STARR-seq mESC enhancer starr_19915 Neighboring gene predicted gene, 39072

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions. Cheng JB, et al. J Biol Chem, 2004 Sep 3. PMID 15220348, Free PMC Article
  2. Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family. Cheng JB, et al. J Biol Chem, 2004 Sep 3. PMID 15220349, Free PMC Article
  3. CIN85 interacting proteins in B cells-specific role for SHIP-1. Büchse T, et al. Mol Cell Proteomics, 2011 Oct. PMID 21725061, Free PMC Article
  4. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
  5. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. wax monoester synthesis in mammals involves a two step biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax synthase enzymes
    Title: Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family.
  2. fatty alcohol synthesis in mammals is accomplished by two fatty acyl-CoA reductase isozymes that are expressed at high levels in tissues known to synthesize wax monoesters and ether lipids
    Title: Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alcohol-forming long-chain fatty acyl-CoA reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alcohol-forming very long-chain fatty acyl-CoA reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ether lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerophospholipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty-acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty-acyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in wax biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
fatty acyl-CoA reductase 1
Names
male sterility domain containing 2
NP_001272760.1
NP_001347597.1
NP_001347598.1
NP_081655.2
XP_006508192.1
XP_006508193.1
XP_006508194.1
XP_030098792.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285831.2 → NP_001272760.1  fatty acyl-CoA reductase 1 isoform 2

    See identical proteins and their annotated locations for NP_001272760.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the coding region compared to variant 1. The resulting isoform (2) is the same length and has the same N- and C-termini compared to isoform 1 but differs at an internal segment.
    Source sequence(s)
    AC102841, AC156987, AK033674
    Consensus CDS
    CCDS72024.1
    UniProtKB/Swiss-Prot
    Q922J9
    Related
    ENSMUSP00000064334.9, ENSMUST00000067929.15
    Conserved Domains (2) summary
    cd05236
    Location:11 → 330
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:371 → 447
    Sterile; Male sterility protein

  2. NM_001360668.1 → NP_001347597.1  fatty acyl-CoA reductase 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AC102841, AC156987
    Consensus CDS
    CCDS40093.1
    UniProtKB/Swiss-Prot
    Q8BZS2, Q922J9, Q9CXE8, Q9D0Q1, Q9DAU2
    Related
    ENSMUSP00000128695.2, ENSMUST00000164745.8
    Conserved Domains (2) summary
    cd05236
    Location:11 → 330
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:357 → 447
    Sterile; Male sterility protein

  3. NM_001360669.1 → NP_001347598.1  fatty acyl-CoA reductase 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AC102841, AC156987
    Consensus CDS
    CCDS40093.1
    UniProtKB/Swiss-Prot
    Q8BZS2, Q922J9, Q9CXE8, Q9D0Q1, Q9DAU2
    Conserved Domains (2) summary
    cd05236
    Location:11 → 330
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:357 → 447
    Sterile; Male sterility protein

  4. NM_027379.4 → NP_081655.2  fatty acyl-CoA reductase 1 isoform 1

    See identical proteins and their annotated locations for NP_081655.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AC102841, AC156987, AK014486
    Consensus CDS
    CCDS40093.1
    UniProtKB/Swiss-Prot
    Q8BZS2, Q922J9, Q9CXE8, Q9D0Q1, Q9DAU2
    Related
    ENSMUSP00000033018.9, ENSMUST00000033018.15
    Conserved Domains (2) summary
    cd05236
    Location:11 → 330
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:357 → 447
    Sterile; Male sterility protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    113113008..113170713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242932.2 → XP_030098792.1  fatty acyl-CoA reductase 1 isoform X2

    Conserved Domains (2) summary
    cd05236
    Location:11 → 330
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:371 → 447
    Sterile; Male sterility protein

  2. XM_006508130.4 → XP_006508193.1  fatty acyl-CoA reductase 1 isoform X1

    See identical proteins and their annotated locations for XP_006508193.1

    UniProtKB/Swiss-Prot
    Q8BZS2, Q922J9, Q9CXE8, Q9D0Q1, Q9DAU2
    Conserved Domains (2) summary
    cd05236
    Location:11 → 330
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:357 → 447
    Sterile; Male sterility protein

  3. XM_006508129.4 → XP_006508192.1  fatty acyl-CoA reductase 1 isoform X1

    See identical proteins and their annotated locations for XP_006508192.1

    UniProtKB/Swiss-Prot
    Q8BZS2, Q922J9, Q9CXE8, Q9D0Q1, Q9DAU2
    Conserved Domains (2) summary
    cd05236
    Location:11 → 330
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:357 → 447
    Sterile; Male sterility protein

  4. XM_006508131.4 → XP_006508194.1  fatty acyl-CoA reductase 1 isoform X1

    See identical proteins and their annotated locations for XP_006508194.1

    UniProtKB/Swiss-Prot
    Q8BZS2, Q922J9, Q9CXE8, Q9D0Q1, Q9DAU2
    Conserved Domains (2) summary
    cd05236
    Location:11 → 330
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:357 → 447
    Sterile; Male sterility protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_026143.2: Suppressed sequence

    Description
    NM_026143.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922J9.1 GenPept UniProtKB/Swiss-Prot:Q922J9

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