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Armh4 armadillo-like helical domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 67419, updated on 30-Apr-2024

Summary

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Official Symbol
Armh4provided by MGI
Official Full Name
armadillo-like helical domain containing 4provided by MGI
Primary source
MGI:MGI:1914669
See related
Ensembl:ENSMUSG00000036242 AllianceGenome:MGI:1914669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3632451O06Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including facial prominence; heart; nervous system; trunk mesenchyme; and vibrissa. Orthologous to human ARMH4 (armadillo like helical domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 12.4), bladder adult (RPKM 10.1) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 C1; 14 25.78 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (49919017..50020843, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (49681560..49783480, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member F4 Neighboring gene predicted gene, 52146 Neighboring gene STARR-seq mESC enhancer starr_36633 Neighboring gene predicted gene, 22116 Neighboring gene STARR-seq mESC enhancer starr_36634 Neighboring gene STARR-seq mESC enhancer starr_36635 Neighboring gene 60S ribosomal protein L24 pseudogene Neighboring gene predicted gene, 36146 Neighboring gene STARR-seq mESC enhancer starr_36636 Neighboring gene STARR-seq mESC enhancer starr_36637 Neighboring gene STARR-seq mESC enhancer starr_36638 Neighboring gene STARR-seq mESC enhancer starr_36639 Neighboring gene STARR-seq mESC enhancer starr_36640 Neighboring gene predicted gene 8417 Neighboring gene STARR-seq mESC enhancer starr_36642 Neighboring gene olfactory receptor family 4 subfamily N member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The developmental Wnt signaling pathway effector β-catenin/TCF mediates hepatic functions of the sex hormone estradiol in regulating lipid metabolism. Tian L, et al. PLoS Biol, 2019 Oct. PMID 31589598, Free PMC Article
  2. Armadillo-like helical domain containing-4 is dynamically expressed in both the first and second heart fields. Conway SJ, et al. Gene Expr Patterns, 2019 Dec. PMID 31655130, Free PMC Article
  3. Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes. Christoforou N, et al. J Clin Invest, 2008 Mar. PMID 18246200, Free PMC Article
  4. Efficient capture of cardiogenesis-associated genes expressed in ES cells. Terami H, et al. Biochem Biophys Res Commun, 2007 Mar 30. PMID 17286962
  5. Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects. de Soysa TY, et al. Nature, 2019 Aug. PMID 31341279, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables TORC2 complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of TORC2 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
armadillo-like helical domain-containing protein 4
Names
uncharacterized protein C14orf37 homolog
upstream of mTORC2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358244.1 → NP_001345173.1  armadillo-like helical domain-containing protein 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC140393, AK014402, AK028180
    Consensus CDS
    CCDS88649.1
    UniProtKB/TrEMBL
    D3Z566
    Related
    ENSMUSP00000113609.2, ENSMUST00000118129.2
    Conserved Domains (1) summary
    pfam15767
    Location:48 → 606
    DUF4696; Domain of unknown function (DUF4696)

  2. NM_026142.5 → NP_080418.2  armadillo-like helical domain-containing protein 4 precursor

    See identical proteins and their annotated locations for NP_080418.2

    Status: VALIDATED

    Source sequence(s)
    AC140393, AK014402, AK032093
    Consensus CDS
    CCDS36903.1
    UniProtKB/Swiss-Prot
    Q8BFQ7, Q8BT18, Q8R1Q5, Q9D6C5
    Related
    ENSMUSP00000036220.7, ENSMUST00000036972.14
    Conserved Domains (1) summary
    pfam15767
    Location:48 → 606
    DUF4696; Domain of unknown function (DUF4696)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    49919017..50020843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519452.5 → XP_006519515.1  armadillo-like helical domain-containing protein 4 isoform X1

    Conserved Domains (1) summary
    pfam15767
    Location:48 → 606
    DUF4696; Domain of unknown function (DUF4696)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BT18.2 GenPept UniProtKB/Swiss-Prot:Q8BT18

Gene LinkOut

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