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Armcx2 armadillo repeat containing, X-linked 2 [ Mus musculus (house mouse) ]

Gene ID: 67416, updated on 11-Apr-2024

Summary

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Official Symbol
Armcx2provided by MGI
Official Full Name
armadillo repeat containing, X-linked 2provided by MGI
Primary source
MGI:MGI:1914666
See related
Ensembl:ENSMUSG00000033436 AllianceGenome:MGI:1914666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ALEX2; 3230401N03Rik
Summary
Predicted to be located in mitochondrial outer membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including brain; future brain; liver; reproductive system; and trunk. Orthologous to human ARMCX2 (armadillo repeat containing X-linked 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 29.0), CNS E14 (RPKM 27.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Armcx2 in Genome Data Viewer
Location:
X E3; X 56.27 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (133704891..133709970, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134804142..134809221, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing, X-linked 6 Neighboring gene microRNA 7093 Neighboring gene armadillo repeat containing, X-linked 3 Neighboring gene STARR-seq mESC enhancer starr_47969 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene developmental pluripotency associated 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo. Smith CA, et al. Dev Dyn, 2005 May. PMID 15759267
  2. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. López-Doménech G, et al. Nat Commun, 2012 May 8. PMID 22569362
  3. A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice. Zhou J, et al. Biol Reprod, 2013 Jun. PMID 23677977, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. has a role in specification or development of the interstitial cell lineage in the developing testis
    Title: Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
armadillo repeat-containing X-linked protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166397.1 → NP_001159869.1  armadillo repeat-containing X-linked protein 2

    See identical proteins and their annotated locations for NP_001159869.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks 5' UTR sequence, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK172960, BE986475
    Consensus CDS
    CCDS30401.1
    UniProtKB/Swiss-Prot
    A2AKS5, Q6A058, Q9CXI9
    UniProtKB/TrEMBL
    Q8BJ81
    Related
    ENSMUSP00000108818.3, ENSMUST00000113193.9
    Conserved Domains (3) summary
    sd00044
    Location:543 → 568
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:529 → 778
    Arm_2; Armadillo-like
    NF033761
    Location:141 → 430
    gliding_GltJ; adventurous gliding motility protein GltJ

  2. NM_001166398.1 → NP_001159870.1  armadillo repeat-containing X-linked protein 2

    See identical proteins and their annotated locations for NP_001159870.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two different segments in its 5' UTR sequence, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK081299, AK172960, BE986475
    Consensus CDS
    CCDS30401.1
    UniProtKB/Swiss-Prot
    A2AKS5, Q6A058, Q9CXI9
    UniProtKB/TrEMBL
    Q8BJ81
    Related
    ENSMUSP00000049147.5, ENSMUST00000035559.11
    Conserved Domains (3) summary
    sd00044
    Location:543 → 568
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:529 → 778
    Arm_2; Armadillo-like
    NF033761
    Location:141 → 430
    gliding_GltJ; adventurous gliding motility protein GltJ

  3. NM_026139.4 → NP_080415.3  armadillo repeat-containing X-linked protein 2

    See identical proteins and their annotated locations for NP_080415.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK044926, AK053354, AK172960, BE986475
    Consensus CDS
    CCDS30401.1
    UniProtKB/Swiss-Prot
    A2AKS5, Q6A058, Q9CXI9
    UniProtKB/TrEMBL
    Q8BJ81
    Related
    ENSMUSP00000127305.2, ENSMUST00000168264.2
    Conserved Domains (3) summary
    sd00044
    Location:543 → 568
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:529 → 778
    Arm_2; Armadillo-like
    NF033761
    Location:141 → 430
    gliding_GltJ; adventurous gliding motility protein GltJ

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    133704891..133709970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528602.2 → XP_006528665.1  armadillo repeat-containing X-linked protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006528665.1

    UniProtKB/Swiss-Prot
    A2AKS5, Q6A058, Q9CXI9
    UniProtKB/TrEMBL
    Q8BJ81
    Conserved Domains (3) summary
    sd00044
    Location:543 → 568
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:529 → 778
    Arm_2; Armadillo-like
    NF033761
    Location:141 → 430
    gliding_GltJ; adventurous gliding motility protein GltJ

  2. XM_006528600.2 → XP_006528663.1  armadillo repeat-containing X-linked protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006528663.1

    UniProtKB/Swiss-Prot
    A2AKS5, Q6A058, Q9CXI9
    UniProtKB/TrEMBL
    Q8BJ81
    Conserved Domains (3) summary
    sd00044
    Location:543 → 568
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:529 → 778
    Arm_2; Armadillo-like
    NF033761
    Location:141 → 430
    gliding_GltJ; adventurous gliding motility protein GltJ

  3. XM_036162079.1 → XP_036017972.1  armadillo repeat-containing X-linked protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A2AKS5, Q6A058, Q9CXI9
    UniProtKB/TrEMBL
    Q8BJ81
    Conserved Domains (3) summary
    sd00044
    Location:543 → 568
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:529 → 778
    Arm_2; Armadillo-like
    NF033761
    Location:141 → 430
    gliding_GltJ; adventurous gliding motility protein GltJ

  4. XM_006528603.3 → XP_006528666.1  armadillo repeat-containing X-linked protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006528666.1

    UniProtKB/Swiss-Prot
    A2AKS5, Q6A058, Q9CXI9
    UniProtKB/TrEMBL
    Q8BJ81
    Conserved Domains (3) summary
    sd00044
    Location:543 → 568
    HEAT; HEAT repeat [structural motif]
    pfam04826
    Location:529 → 778
    Arm_2; Armadillo-like
    NF033761
    Location:141 → 430
    gliding_GltJ; adventurous gliding motility protein GltJ
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6A058.2 GenPept UniProtKB/Swiss-Prot:Q6A058

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