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Nts neurotensin [ Mus musculus (house mouse) ]

Gene ID: 67405, updated on 5-Apr-2024

Summary

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Official Symbol
Ntsprovided by MGI
Official Full Name
neurotensinprovided by MGI
Primary source
MGI:MGI:1328351
See related
Ensembl:ENSMUSG00000019890 AllianceGenome:MGI:1328351
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NN; NT; NT/N; NTS1; NMN-125; 5033428E16Rik
Summary
Predicted to enable neuropeptide receptor binding activity and receptor ligand activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; neuropeptide signaling pathway; and visual learning. Predicted to be located in intracellular membrane-bounded organelle and neuronal cell body. Predicted to be active in axon terminus. Is expressed in central nervous system; genitourinary system; heart ventricle; jaw; and retina. Orthologous to human NTS (neurotensin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 17.8), large intestine adult (RPKM 7.5) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Nts in Genome Data Viewer
Location:
10 D1; 10 53.56 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (102317617..102326294, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (102481756..102490418, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27741 Neighboring gene predicted gene, 26278 Neighboring gene MGAT4 family, member C Neighboring gene microRNA 3059 Neighboring gene STARR-seq mESC enhancer starr_27742 Neighboring gene STARR-seq mESC enhancer starr_27743 Neighboring gene STARR-seq mESC enhancer starr_27744 Neighboring gene STARR-seq mESC enhancer starr_27745 Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 Neighboring gene predicted gene 5175

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Metabolitin regulates intestinal fat absorption via lymphatic endothelial cells derived neurotensin. Liu C, et al. J Hepatol, 2023 Jul. PMID 36567053
  2. Neurotensin expression, regulation, and function during the ovulatory period in the mouse ovary†. Shrestha K, et al. Biol Reprod, 2023 Jan 14. PMID 36345168, Free PMC Article
  3. Neurotensin Release from Dopamine Neurons Drives Long-Term Depression of Substantia Nigra Dopamine Signaling. Tschumi CW, et al. J Neurosci, 2022 Aug 10. PMID 35794014, Free PMC Article
  4. Neurotensin Attenuates Nociception by Facilitating Inhibitory Synaptic Transmission in the Mouse Spinal Cord. Zhang MM, et al. Front Neural Circuits, 2021. PMID 35002634, Free PMC Article
  5. Inhibition of impulsive action by projection-defined prefrontal pyramidal neurons. Li B, et al. Proc Natl Acad Sci U S A, 2020 Jul 21. PMID 32631999, Free PMC Article

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neurotensin counteracts hair growth inhibition induced by chronic restraint stress.
    Title: Neurotensin counteracts hair growth inhibition induced by chronic restraint stress.
  2. Regulation of Atherosclerosis Development by Neurotensin Derived From Lymphatic Endothelial Cells in Mice.
    Title: Regulation of Atherosclerosis Development by Neurotensin Derived From Lymphatic Endothelial Cells in Mice.
  3. Metabolitin regulates intestinal fat absorption via lymphatic endothelial cells derived neurotensin.
    Title: Metabolitin regulates intestinal fat absorption via lymphatic endothelial cells derived neurotensin.
  4. Neurotensin expression, regulation, and function during the ovulatory period in the mouse ovarydagger.
    Title: Neurotensin expression, regulation, and function during the ovulatory period in the mouse ovary†.
  5. Neurotensin Release from Dopamine Neurons Drives Long-Term Depression of Substantia Nigra Dopamine Signaling.
    Title: Neurotensin Release from Dopamine Neurons Drives Long-Term Depression of Substantia Nigra Dopamine Signaling.
  6. Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells.
    Title: Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells.
  7. Neurotensin Attenuates Nociception by Facilitating Inhibitory Synaptic Transmission in the Mouse Spinal Cord.
    Title: Neurotensin Attenuates Nociception by Facilitating Inhibitory Synaptic Transmission in the Mouse Spinal Cord.
  8. Effect of neurotensin on cultured mouse preimplantation embryos.
    Title: Effect of neurotensin on cultured mouse preimplantation embryos.
  9. Study found that locally-released neurotensin (NT) and dynorphin (Dyn) antagonistically regulated central amygdala (CeA) inhibitory inputs onto oval bed nucleus of the stria terminalis (ovBNST) neurons. NT and Dyn respectively increased and decreased CeA-toovBNST inhibitory inputs through NT receptor 1 and kappa opioid receptor. NT and Dyn mRNAs were highly co-localized in ovBNST neurons.
    Title: Neurotensin and dynorphin Bi-Directionally modulate CeA inhibition of oval BNST neurons in male mice.
  10. Study reveals multiple populations of neurotensin neurons that provide direct afferents to the ventral tegmental area and which may regulate specific aspects of motivated behavior.
    Title: Determination of neurotensin projections to the ventral tegmental area in mice.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables neuropeptide hormone activity TAS
Traceable Author Statement
more info
 PubMed 
enables neuropeptide receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within blood vessel diameter maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in killing of cells of another organism ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in visual learning ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
neurotensin/neuromedin N
Names
neuromedin N

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024435.2 → NP_077755.1  neurotensin/neuromedin N precursor

    See identical proteins and their annotated locations for NP_077755.1

    Status: PROVISIONAL

    Source sequence(s)
    BC043024
    Consensus CDS
    CCDS24154.1
    UniProtKB/Swiss-Prot
    Q9D3P9
    Related
    ENSMUSP00000020040.4, ENSMUST00000020040.5
    Conserved Domains (1) summary
    pfam07421
    Location:6 → 168
    Pro-NT_NN; Neurotensin/neuromedin N precursor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    102317617..102326294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513992.4 → XP_006514055.1  neurotensin/neuromedin N isoform X1

    Conserved Domains (1) summary
    pfam07421
    Location:1 → 129
    Pro-NT_NN; Neurotensin/neuromedin N precursor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D3P9.1 GenPept UniProtKB/Swiss-Prot:Q9D3P9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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