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Carnmt1 carnosine N-methyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 67383, updated on 5-Mar-2024

Summary

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Official Symbol
Carnmt1provided by MGI
Official Full Name
carnosine N-methyltransferase 1provided by MGI
Primary source
MGI:MGI:1914633
See related
Ensembl:ENSMUSG00000024726 AllianceGenome:MGI:1914633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410127L17Rik
Summary
Predicted to enable carnosine N-methyltransferase activity and protein homodimerization activity. Predicted to be involved in carnosine metabolic process. Predicted to act upstream of or within methylation. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human CARNMT1 (carnosine N-methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 5.9), liver E14 (RPKM 5.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Carnmt1 in Genome Data Viewer
Location:
19 B; 19 13.18 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (18648099..18684565)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (18670759..18707201)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene osteoclast stimulating factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E7637 Neighboring gene nicotinamide riboside kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E9992 Neighboring gene RIKEN cDNA D030056L22 gene Neighboring gene STARR-seq mESC enhancer starr_45692 Neighboring gene STARR-positive B cell enhancer ABC_E3247 Neighboring gene predicted gene, 23238 Neighboring gene transient receptor potential cation channel, subfamily M, member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism.
    Title: Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables carnosine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carnosine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carnosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carnosine metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
carnosine N-methyltransferase
Names
UPF0586 protein C9orf41 homolog
NP_001363980.1
NP_001363981.1
NP_001363982.1
NP_001363983.1
NP_001363984.1
NP_080396.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377051.1 → NP_001363980.1  carnosine N-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134906
    Conserved Domains (1) summary
    pfam07942
    Location:90 → 355
    N2227; N2227-like protein

  2. NM_001377052.1 → NP_001363981.1  carnosine N-methyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC134906
    Conserved Domains (1) summary
    pfam07942
    Location:83 → 348
    N2227; N2227-like protein

  3. NM_001377053.1 → NP_001363982.1  carnosine N-methyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC134906
    Conserved Domains (1) summary
    pfam07942
    Location:135 → 333
    N2227; N2227-like protein

  4. NM_001377054.1 → NP_001363983.1  carnosine N-methyltransferase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC134906
    Conserved Domains (1) summary
    pfam07942
    Location:90 → 288
    N2227; N2227-like protein

  5. NM_001377055.1 → NP_001363984.1  carnosine N-methyltransferase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC134906
    Conserved Domains (1) summary
    pfam07942
    Location:83 → 281
    N2227; N2227-like protein

  6. NM_026120.5 → NP_080396.2  carnosine N-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_080396.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC134906
    Consensus CDS
    CCDS29689.1
    UniProtKB/Swiss-Prot
    Q80UY1, Q9CWF3
    Related
    ENSMUSP00000025632.10, ENSMUST00000025632.11
    Conserved Domains (1) summary
    pfam07942
    Location:135 → 400
    N2227; N2227-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    18648099..18684565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004940170.1 RNA Sequence

  2. XR_004940171.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80UY1.1 GenPept UniProtKB/Swiss-Prot:Q80UY1

Gene LinkOut

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