Qprt quinolinate phosphoribosyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Qprtprovided by MGI
Official Full Name: quinolinate phosphoribosyltransferaseprovided by MGI
Primary source: MGI:MGI:1914625
See related: Ensembl:ENSMUSG00000030674 AllianceGenome:MGI:1914625
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: QPRTase; 2410027J01Rik
Summary: Predicted to enable identical protein binding activity and nicotinate-nucleotide diphosphorylase (carboxylating) activity. Predicted to be involved in NAD biosynthetic process and quinolinate catabolic process. Predicted to act upstream of or within pyridine nucleotide biosynthetic process. Predicted to be part of catalytic complex. Predicted to be active in cytoplasm. Is expressed in several structures, including hindlimb; integumental system; liver; skeleton; and urinary system. Orthologous to human QPRT (quinolinate phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 87.0), liver E18 (RPKM 77.3) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.33 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (126706942..126721201, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (127107770..127122029, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatocyte nuclear factor 4alpha mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury.
Title: Hepatocyte nuclear factor 4α mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury.
Deletion of quinolinate phosphoribosyltransferase gene accelerates frailty phenotypes and neuromuscular decline with aging in a sex-specific pattern.
Title: Deletion of quinolinate phosphoribosyltransferase gene accelerates frailty phenotypes and neuromuscular decline with aging in a sex-specific pattern.
Quinolinate Phosphoribosyltransferase Promotes Invasiveness of Breast Cancer Through Myosin Light Chain Phosphorylation.
Title: Quinolinate Phosphoribosyltransferase Promotes Invasiveness of Breast Cancer Through Myosin Light Chain Phosphorylation.
Hepatic QPRT thus likely served as a cellular factor that dampened productive hepatitis c virus replication.
Title: Quinolinate Phosphoribosyltransferase is an Antiviral Host Factor Against Hepatitis C Virus Infection.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity	ISO Inferred from Sequence Orthology more info
enables pentosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NAD biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in NAD biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pyridine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in quinolinate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within quinolinate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in quinolinate metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of catalytic complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nicotinate-nucleotide pyrophosphorylase [carboxylating]

Names: QAPRTase; nicotinate-nucleotide pyrophosphorylase

NP_598447.1

EC 2.4.2.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133686.1 → NP_598447.1 nicotinate-nucleotide pyrophosphorylase [carboxylating]

See identical proteins and their annotated locations for NP_598447.1

Status: PROVISIONAL

Source sequence(s)

BC011191

Consensus CDS

CCDS40138.1

UniProtKB/Swiss-Prot

Q91X91

Related

ENSMUSP00000032912.6, ENSMUST00000032912.6

Conserved Domains (2) summary

cd01572
Location:17 → 284

QPRTase; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with ...

TIGR00078
Location:21 → 285

nadC; nicotinate-nucleotide pyrophosphorylase