Prss3b serine protease 3B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prss3bprovided by MGI
Official Full Name: serine protease 3Bprovided by MGI
Primary source: MGI:MGI:1914623
See related: Ensembl:ENSMUSG00000029882 AllianceGenome:MGI:1914623
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: T7; 2210010C04Rik
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in ductus deferens; gallbladder; pancreas; pancreas tip epithelium; and testis. Used to study pancreatitis. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human PRSS1 (serine protease 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 6 B1; 6 19.1 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (41007202..41012443, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (41030268..41035509, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within zymogen activation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: trypsinogen 7

Names: cationic trypsinogen (isoform T7); protease, serine 3B

NP_075822.3

EC 3.4.21.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_006980.1

Range

139474..144715 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_023333.4 → NP_075822.3 trypsinogen 7 precursor

See identical proteins and their annotated locations for NP_075822.3

Status: VALIDATED

Source sequence(s)

AK007943, AK008460, AK008695

Consensus CDS

CCDS20043.1

UniProtKB/TrEMBL

Q9CPN9, Q9D7Y7

Related

ENSMUSP00000031931.6, ENSMUST00000031931.6

Conserved Domains (2) summary

smart00020
Location:24 → 240

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:25 → 243

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...