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Zfp606 zinc finger protein 606 [ Mus musculus (house mouse) ]

Gene ID: 67370, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp606provided by MGI
Official Full Name
zinc finger protein 606provided by MGI
Primary source
MGI:MGI:1914620
See related
Ensembl:ENSMUSG00000030386 AllianceGenome:MGI:1914620
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410022M24Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in genitourinary system. Orthologous to human ZNF606 (zinc finger protein 606). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 3.9), CNS E11.5 (RPKM 3.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp606 in Genome Data Viewer
Location:
7 A1; 7 7.52 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12212208..12230162)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (12478280..12496235)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 551 Neighboring gene vomeronasal 2, receptor, pseudogene 53 Neighboring gene STARR-seq mESC enhancer starr_18051 Neighboring gene RIKEN cDNA 2900092C05 gene Neighboring gene STARR-seq mESC enhancer starr_18052 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18053 Neighboring gene vomeronasal 2, receptor 53 Neighboring gene PC4 and SFRS1 interacting protein 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 606

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039951.2 → NP_001035040.1  zinc finger protein 606 isoform 2

    See identical proteins and their annotated locations for NP_001035040.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region and lacks several coding exons, compared to variant 1. This results in a shorter isoform (2) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK032301, AK165095, BY278345
    Consensus CDS
    CCDS85215.1
    UniProtKB/TrEMBL
    Q2TAX9
    Related
    ENSMUSP00000147558.2, ENSMUST00000123589.8

  2. NM_001310620.1 → NP_001297549.1  zinc finger protein 606 isoform 3

    See identical proteins and their annotated locations for NP_001297549.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' exon. This variant represents translation initiation at an alternate AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (3) that has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC139131, AK139269, AK143200
    Consensus CDS
    CCDS80663.1
    UniProtKB/TrEMBL
    Q69Z88
    Conserved Domains (5) summary
    smart00349
    Location:5 → 65
    KRAB; krueppel associated box
    COG5048
    Location:328 → 734
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:403 → 423
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5 → 44
    KRAB; KRAB box
    pfam13465
    Location:583 → 608
    zf-H2C2_2; Zinc-finger double domain

  3. NM_026112.4 → NP_080388.2  zinc finger protein 606 isoform 1

    See identical proteins and their annotated locations for NP_080388.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK139269, AK143200
    Consensus CDS
    CCDS20810.1
    UniProtKB/TrEMBL
    Q7TSV0
    Related
    ENSMUSP00000096421.4, ENSMUST00000098822.10
    Conserved Domains (6) summary
    smart00349
    Location:63 → 123
    KRAB; krueppel associated box
    COG5048
    Location:386 → 792
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:739 → 761
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:63 → 102
    KRAB; KRAB box
    pfam13465
    Location:641 → 666
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    12212208..12230162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540320.4 → XP_006540383.1  zinc finger protein 606 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:24 → 84
    KRAB; krueppel associated box
    COG5048
    Location:347 → 753
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:422 → 442
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. XR_881784.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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