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Dynlt5 dynein light chain Tctex-type 5 [ Mus musculus (house mouse) ]

Gene ID: 67344, updated on 5-Mar-2024

Summary

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Official Symbol
Dynlt5provided by MGI
Official Full Name
dynein light chain Tctex-type 5provided by MGI
Primary source
MGI:MGI:1914594
See related
Ensembl:ENSMUSG00000028523 AllianceGenome:MGI:1914594
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tctex1d1; 1700055O19Rik
Summary
Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. Orthologous to human DYNLT5 (dynein light chain Tctex-type family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 46.3) See more
Orthologs
human all
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Genomic context

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Location:
4 C6; 4 47.25 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (102835900..102862419)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (102978703..103005594)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24869 Neighboring gene SH3-domain GRB2-like (endophilin) interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_10929 Neighboring gene STARR-seq mESC enhancer starr_10931 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:102663627-102663912 Neighboring gene predicted gene 12709 Neighboring gene STARR-seq mESC enhancer starr_10932 Neighboring gene expressed sequence BB031773 Neighboring gene insulin-like 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:102737628-102737949 Neighboring gene dynein axonemal intermediate chain 4 Neighboring gene MEIR1 treanscription regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC118261

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dynein light chain Tctex-type 5
Names
Tctex1 domain containing 1
tctex1 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163767.2 → NP_001157239.1  dynein light chain Tctex-type 5 isoform 1

    See identical proteins and their annotated locations for NP_001157239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AL732543
    Consensus CDS
    CCDS18405.1
    UniProtKB/Swiss-Prot
    Q80ZP4, Q9CVR8, Q9D5I4
    UniProtKB/TrEMBL
    B7ZNE0
    Related
    ENSMUSP00000030248.6, ENSMUST00000030248.12
    Conserved Domains (1) summary
    pfam03645
    Location:75 → 171
    Tctex-1; Tctex-1 family

  2. NM_001163768.2 → NP_001157240.1  dynein light chain Tctex-type 5 isoform 2

    See identical proteins and their annotated locations for NP_001157240.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AL732543
    Consensus CDS
    CCDS51246.1
    UniProtKB/TrEMBL
    A2AIZ3, A2AIZ4, G3UW44
    Related
    ENSMUSP00000116692.3, ENSMUST00000140654.9
    Conserved Domains (1) summary
    cl41776
    Location:13 → 116
    DLC-like_SF; dynein light chain (DLC)-like domain superfamily

  3. NM_001374706.2 → NP_001361635.1  dynein light chain Tctex-type 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (1).
    Source sequence(s)
    AL732543
    Consensus CDS
    CCDS89789.1
    UniProtKB/TrEMBL
    A0A1Y7VP18
    Related
    ENSMUSP00000152761.2, ENSMUST00000223169.2
    Conserved Domains (1) summary
    pfam03645
    Location:79 → 175
    Tctex-1; Tctex-1 family

  4. NM_001379131.2 → NP_001366060.1  dynein light chain Tctex-type 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL732543
    UniProtKB/TrEMBL
    A2AIZ3, A2AIZ4, G3UW44
    Conserved Domains (1) summary
    cl41776
    Location:13 → 116
    DLC-like_SF; dynein light chain (DLC)-like domain superfamily

  5. NM_001379132.2 → NP_001366061.1  dynein light chain Tctex-type 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL732543
    UniProtKB/TrEMBL
    A2AIZ3, A2AIZ4, G3UW44
    Related
    ENSMUSP00000117319.3, ENSMUST00000125417.9
    Conserved Domains (1) summary
    cl41776
    Location:13 → 116
    DLC-like_SF; dynein light chain (DLC)-like domain superfamily

  6. NM_026100.4 → NP_080376.1  dynein light chain Tctex-type 5 isoform 1

    See identical proteins and their annotated locations for NP_080376.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL732543
    Consensus CDS
    CCDS18405.1
    UniProtKB/Swiss-Prot
    Q80ZP4, Q9CVR8, Q9D5I4
    UniProtKB/TrEMBL
    B7ZNE0
    Related
    ENSMUSP00000128228.3, ENSMUST00000169211.3
    Conserved Domains (1) summary
    pfam03645
    Location:75 → 171
    Tctex-1; Tctex-1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    102835900..102862419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D5I4.1 GenPept UniProtKB/Swiss-Prot:Q9D5I4

Gene LinkOut

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