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Atp8b3 ATPase, class I, type 8B, member 3 [ Mus musculus (house mouse) ]

Gene ID: 67331, updated on 11-Apr-2024

Summary

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Official Symbol
Atp8b3provided by MGI
Official Full Name
ATPase, class I, type 8B, member 3provided by MGI
Primary source
MGI:MGI:1914581
See related
Ensembl:ENSMUSG00000003341 AllianceGenome:MGI:1914581
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ATPIK; SAPLT; 1700042F02Rik; 1700056N23Rik
Summary
Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Acts upstream of or within binding activity of sperm to zona pellucida and phospholipid translocation. Located in acrosomal vesicle. Is integral component of membrane. Is expressed in several structures, including heart; testis; trunk; and white fat. Orthologous to human ATP8B3 (ATPase phospholipid transporting 8B3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 456.8) See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80355418..80374987, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80519584..80539154, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40716 Neighboring gene one cut domain, family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1124 Neighboring gene REX1, RNA exonuclease 1 Neighboring gene predicted gene, 31057 Neighboring gene STARR-positive B cell enhancer ABC_E10628 Neighboring gene STARR-positive B cell enhancer mm9_chr10:80032416-80032717 Neighboring gene Kruppel-like transcription factor 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of Atp8b3 in murine testis and its characterization as a testis specific P-type ATPase. Gong EY, et al. Reproduction, 2009 Feb. PMID 19017724
  2. A novel aminophospholipid transporter exclusively expressed in spermatozoa is required for membrane lipid asymmetry and normal fertilization. Wang L, et al. Dev Biol, 2004 Mar 1. PMID 14975727
  3. Identification and integrative analysis of 28 novel genes specifically expressed and developmentally regulated in murine spermatogenic cells. Hong S, et al. J Biol Chem, 2005 Mar 4. PMID 15613475
  4. Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. Chiellini C, et al. J Cell Physiol, 2003 May. PMID 12652657
  5. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within binding of sperm to zona pellucida IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phospholipid translocation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phospholipid-transporting ATPase IK
Names
sperm aminophospholipid transporter
spermatozoan aminophospholipid translocase
NP_080370.2
XP_006514047.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026094.3 → NP_080370.2  phospholipid-transporting ATPase IK

    See identical proteins and their annotated locations for NP_080370.2

    Status: PROVISIONAL

    Source sequence(s)
    AY364445
    Consensus CDS
    CCDS24024.1
    UniProtKB/Swiss-Prot
    Q6UQ17
    Related
    ENSMUSP00000020383.5, ENSMUST00000020383.6
    Conserved Domains (5) summary
    COG4087
    Location:839 → 890
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01652
    Location:45 → 1131
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam13246
    Location:483 → 580
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:20 → 96
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:883 → 1131
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80355418..80374987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513984.3 → XP_006514047.1  phospholipid-transporting ATPase IK isoform X1

    Conserved Domains (1) summary
    cd02073
    Location:47 → 969
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RNA

  1. XR_380430.5 RNA Sequence

    Related
    ENSMUST00000220326.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UQ17.1 GenPept UniProtKB/Swiss-Prot:Q6UQ17

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