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Adissp adipose secreted signaling protein [ Mus musculus (house mouse) ]

Gene ID: 67326, updated on 5-Mar-2024

Summary

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Official Symbol
Adisspprovided by MGI
Official Full Name
adipose secreted signaling proteinprovided by MGI
Primary source
MGI:MGI:1914576
See related
Ensembl:ENSMUSG00000027327 AllianceGenome:MGI:1914576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700037H04Rik
Summary
Predicted to enable protein phosphatase 1 binding activity. Predicted to be involved in positive regulation of NIK/NF-kappaB signaling and positive regulation of transforming growth factor beta receptor signaling pathway. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and thymus. Orthologous to human C20orf27 (chromosome 20 open reading frame 27). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 276.7), mammary gland adult (RPKM 135.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Adissp in Genome Data Viewer
Location:
2 F1; 2 63.28 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130988235..131002001, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131146315..131160085, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 30378 Neighboring gene heat shock protein 12B Neighboring gene STARR-seq mESC enhancer starr_05701 Neighboring gene predicted gene 14232 Neighboring gene sperm flagellar 1 Neighboring gene centromere protein B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A brown fat-enriched adipokine Adissp controls adipose thermogenesis and glucose homeostasis. Chen Q, et al. Nat Commun, 2022 Dec 10. PMID 36496438, Free PMC Article
  2. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase 1 binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adaptive thermogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein kinase A signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adipose-secreted signaling protein
Names
UPF0687 protein C20orf27 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311138.1 → NP_001298067.1  adipose-secreted signaling protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)
    Source sequence(s)
    AK006622, AL831736
    Consensus CDS
    CCDS79849.1
    UniProtKB/TrEMBL
    F8WIU1
    Related
    ENSMUSP00000028800.6, ENSMUST00000028800.12
    Conserved Domains (1) summary
    pfam15006
    Location:31 → 176
    DUF4517; Domain of unknown function (DUF4517)

  2. NM_001361375.1 → NP_001348304.1  adipose-secreted signaling protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK006622, AL831736, BY706619, CX222938
    Conserved Domains (1) summary
    pfam15006
    Location:1 → 132
    DUF4517; Domain of unknown function (DUF4517)

  3. NM_026091.3 → NP_080367.1  adipose-secreted signaling protein isoform 2

    See identical proteins and their annotated locations for NP_080367.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK003406, AL831736, BY706619
    Consensus CDS
    CCDS16756.1
    UniProtKB/Swiss-Prot
    Q9CVT3, Q9D1K7
    UniProtKB/TrEMBL
    H7BXB9
    Related
    ENSMUSP00000099477.4, ENSMUST00000103188.10
    Conserved Domains (1) summary
    pfam15006
    Location:28 → 173
    DUF4517; Domain of unknown function (DUF4517)

RNA

  1. NR_154886.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL831736
    Related
    ENSMUST00000184535.8

  2. NR_154887.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL831736

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    130988235..131002001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251987.2 → XP_030107847.1  adipose-secreted signaling protein isoform X1

    UniProtKB/Swiss-Prot
    Q9CVT3, Q9D1K7
    UniProtKB/TrEMBL
    H7BXB9
    Conserved Domains (1) summary
    pfam15006
    Location:28 → 173
    DUF4517; Domain of unknown function (DUF4517)

  2. XM_011239745.3 → XP_011238047.1  adipose-secreted signaling protein isoform X1

    See identical proteins and their annotated locations for XP_011238047.1

    UniProtKB/Swiss-Prot
    Q9CVT3, Q9D1K7
    UniProtKB/TrEMBL
    H7BXB9
    Related
    ENSMUSP00000115000.2, ENSMUST00000133602.8
    Conserved Domains (1) summary
    pfam15006
    Location:28 → 173
    DUF4517; Domain of unknown function (DUF4517)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D1K7.3 GenPept UniProtKB/Swiss-Prot:Q9D1K7

Gene LinkOut

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