U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Inava innate immunity activator [ Mus musculus (house mouse) ]

Gene ID: 67313, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Inavaprovided by MGI
Official Full Name
innate immunity activatorprovided by MGI
Primary source
MGI:MGI:1921579
See related
Ensembl:ENSMUSG00000041605 AllianceGenome:MGI:1921579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D1Mgi54; 1700034M08Rik; 4933426C09Rik; 5730559C18Rik
Summary
Involved in adherens junction maintenance; intestinal epithelial structure maintenance; and positive regulation of protein ubiquitination. Predicted to be located in cytoplasm and nucleus. Is expressed in alimentary system; metanephros; olfactory epithelium; and respiratory system. Human ortholog(s) of this gene implicated in inflammatory bowel disease 29. Orthologous to human INAVA (innate immunity activator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 37.5), stomach adult (RPKM 18.3) and 11 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1 E4; 1 59.61 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (136141259..136162045, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (136213522..136234293, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2562 Neighboring gene STARR-positive B cell enhancer ABC_E1562 Neighboring gene STARR-positive B cell enhancer mm9_chr1:138036481-138036781 Neighboring gene kinesin family member 21B Neighboring gene maestro heat-like repeat family member 3 Neighboring gene STARR-seq mESC enhancer starr_02404 Neighboring gene predicted gene 3878 Neighboring gene G protein-coupled receptor 25 Neighboring gene calmodulin regulated spectrin-associated protein family, member 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. Mohanan V, et al. Science, 2018 Mar 9. PMID 29420262, Free PMC Article
  2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ10901

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in adherens junction maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adherens junction maintenance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adherens junction maintenance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in intestinal epithelial structure maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokine production involved in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
  
involved_in response to peptidoglycan ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
innate immunity activator protein
Names
uncharacterized protein C1orf106 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405152.1 → NP_001392081.1  innate immunity activator protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124550

  2. NM_001405153.1 → NP_001392082.1  innate immunity activator protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124550

  3. NM_001405154.1 → NP_001392083.1  innate immunity activator protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124550

  4. NM_028872.4 → NP_083148.4  innate immunity activator protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124550
    Consensus CDS
    CCDS15325.2
    UniProtKB/Swiss-Prot
    Q7TN12, Q7TN27, Q8BGK3
    Related
    ENSMUSP00000113785.3, ENSMUST00000120339.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    136141259..136162045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153122.1 → XP_036009015.1  innate immunity activator protein isoform X2

    UniProtKB/TrEMBL
    G3X9Z8
    Conserved Domains (1) summary
    pfam11819
    Location:2 → 130
    DUF3338; Domain of unknown function (DUF3338)

  2. XM_036153121.1 → XP_036009014.1  innate immunity activator protein isoform X2

    UniProtKB/TrEMBL
    G3X9Z8
    Conserved Domains (1) summary
    pfam11819
    Location:2 → 130
    DUF3338; Domain of unknown function (DUF3338)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TN12.1 GenPept UniProtKB/Swiss-Prot:Q7TN12

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous