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Nanp N-acetylneuraminic acid phosphatase [ Mus musculus (house mouse) ]

Gene ID: 67311, updated on 5-Mar-2024

Summary

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Official Symbol
Nanpprovided by MGI
Official Full Name
N-acetylneuraminic acid phosphataseprovided by MGI
Primary source
MGI:MGI:1914561
See related
Ensembl:ENSMUSG00000053916 AllianceGenome:MGI:1914561
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hdhd4; 1600031M04Rik
Summary
Predicted to enable N-acylneuraminate-9-phosphatase activity. Predicted to be involved in N-acetylneuraminate biosynthetic process. Predicted to act upstream of or within dephosphorylation. Is expressed in several structures, including alimentary system; liver; and telencephalon ventricular layer. Orthologous to human NANP (N-acetylneuraminic acid phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 18.1), liver E14.5 (RPKM 15.0) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 G3; 2 74.83 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (150871605..150881299, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (151029685..151039379, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E-binding protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06020 Neighboring gene ninein-like Neighboring gene STARR-seq mESC enhancer starr_06023 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3410 Neighboring gene STARR-seq mESC enhancer starr_06026 Neighboring gene predicted gene, 22187 Neighboring gene predicted gene, 24199

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC103377

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acylneuraminate-9-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acylneuraminate-9-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-acetylneuraminate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acetylneuraminate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
N-acylneuraminate-9-phosphatase
Names
haloacid dehalogenase-like hydrolase domain containing 4
haloacid dehalogenase-like hydrolase domain-containing protein 4
neu5Ac-9-Pase
NP_080362.1
XP_006500131.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026086.2 → NP_080362.1  N-acylneuraminate-9-phosphatase

    See identical proteins and their annotated locations for NP_080362.1

    Status: VALIDATED

    Source sequence(s)
    AL808125, BC083086
    Consensus CDS
    CCDS16864.1
    UniProtKB/Swiss-Prot
    Q9CPT3
    Related
    ENSMUSP00000063895.5, ENSMUST00000066640.5
    Conserved Domains (2) summary
    TIGR02253
    Location:6 → 234
    CTE7; HAD superfamily (subfamily IA) hydrolase, TIGR02253
    cl21460
    Location:114 → 239
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    150871605..150881299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500068.4 → XP_006500131.1  N-acylneuraminate-9-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_006500131.1

    Conserved Domains (1) summary
    TIGR02253
    Location:20 → 226
    CTE7; HAD superfamily (subfamily IA) hydrolase, TIGR02253
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPT3.1 GenPept UniProtKB/Swiss-Prot:Q9CPT3

Gene LinkOut

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