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Gprasp1 G protein-coupled receptor associated sorting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 67298, updated on 16-Apr-2024

Summary

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Official Symbol
Gprasp1provided by MGI
Official Full Name
G protein-coupled receptor associated sorting protein 1provided by MGI
Primary source
MGI:MGI:1917418
See related
Ensembl:ENSMUSG00000043384 AllianceGenome:MGI:1917418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GASP; GASP1; 2210415K24Rik; 3110031O14Rik
Summary
Predicted to be involved in G protein-coupled receptor catabolic process and endosome to lysosome transport. Predicted to be located in cytosol and nucleus. Is expressed in brain. Orthologous to human GPRASP1 (G protein-coupled receptor associated sorting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 73.7), CNS E14 (RPKM 50.7) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Gprasp1 in Genome Data Viewer
Location:
X F1; X 57.26 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (134643441..134704217)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (135742692..135803468)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene t-complex 11 family, X-linked 2 Neighboring gene STARR-seq mESC enhancer starr_47970 Neighboring gene thymosin beta 15a Neighboring gene microRNA 7646 Neighboring gene armadillo repeat containing, X-linked 5 Neighboring gene RAB18, member RAS oncogene family pseudogene Neighboring gene microRNA 1970 Neighboring gene STARR-seq mESC enhancer starr_47971 Neighboring gene G protein-coupled receptor associated sorting protein 2 Neighboring gene STARR-seq mESC enhancer starr_47972 Neighboring gene basic helix-loop-helix domain containing, class B9 Neighboring gene predicted gene, 31214

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Arrestin-3 Agonism at Dopamine D(3) Receptors Defines a Subclass of Second-Generation Antipsychotics That Promotes Drug Tolerance. Schamiloglu S, et al. Biol Psychiatry, 2023 Oct 1. PMID 36931452, Free PMC Article
  2. Impaired striatum-dependent behavior in GASP-1-knock-out mice. Mathis C, et al. Genes Brain Behav, 2011 Apr. PMID 21091868
  3. Attenuated behavioural responses to acute and chronic cocaine in GASP-1-deficient mice. Boeuf J, et al. Eur J Neurosci, 2009 Sep. PMID 19712096
  4. Absence of hyperplasia in Gasp-1 overexpressing mice is dependent on myostatin up-regulation. Brun C, et al. Cell Physiol Biochem, 2014. PMID 25277978
  5. Respiratory failure, cleft palate and epilepsy in the mouse model of human Xq22.1 deletion syndrome. Zhou J, et al. Hum Mol Genet, 2014 Jul 15. PMID 24569167, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPRASP1 loss-of-function links to arteriovenous malformations by endothelial activating GPR4 signals.
    Title: GPRASP1 loss-of-function links to arteriovenous malformations by endothelial activating GPR4 signals.
  2. GPRASP proteins are critical negative regulators of hematopoietic stem cell transplantation.
    Title: GPRASP proteins are critical negative regulators of hematopoietic stem cell transplantation.
  3. present the First low resolution solution structure of myostatin-free and myostatin-bound states of GASP-1 and GASP-2
    Title: Alternative binding modes identified for growth and differentiation factor-associated serum protein (GASP) family antagonism of myostatin.
  4. Gasp-1 overexpression resulted in increased myostatin expression.
    Title: Absence of hyperplasia in Gasp-1 overexpressing mice is dependent on myostatin up-regulation.
  5. GASP-1 and GASP-2 are important modulators of GDF-11 and MSTN activity in vivo.
    Title: Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2.
  6. Overexpression of Gasp1 led to an increase in muscle mass observed not before day 15 of postnatal life.
    Title: Ubiquitous Gasp1 overexpression in mice leads mainly to a hypermuscular phenotype.
  7. The pattern of behavioral deficits observed in GASP-1-deficient mice is coherent with current knowledge of the role of striatal G protein-coupled receptor(GPCR)s in acquisition/expression of skilled behavior and motivation.
    Title: Impaired striatum-dependent behavior in GASP-1-knock-out mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC100209

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in G protein-coupled receptor catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G-protein coupled receptor-associated sorting protein 1
Names
GASP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004359.2 → NP_001004359.1  G-protein coupled receptor-associated sorting protein 1

    See identical proteins and their annotated locations for NP_001004359.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB093241, BB619497, BC027187, BC070413, BY099746
    Consensus CDS
    CCDS30409.1
    UniProtKB/Swiss-Prot
    A2AGB6, Q5U4C1, Q8BKR8, Q8BUN4, Q8BYK9, Q8CHF4, Q8R095
    Conserved Domains (1) summary
    pfam04826
    Location:1117 → 1303
    Arm_2; Armadillo-like

  2. NM_001005385.1 → NP_001005385.1  G-protein coupled receptor-associated sorting protein 1

    See identical proteins and their annotated locations for NP_001005385.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB093241, AK083192, BB619497, BC027187, BC070413
    Consensus CDS
    CCDS30409.1
    UniProtKB/Swiss-Prot
    A2AGB6, Q5U4C1, Q8BKR8, Q8BUN4, Q8BYK9, Q8CHF4, Q8R095
    Related
    ENSMUSP00000108770.2, ENSMUST00000113145.8
    Conserved Domains (1) summary
    pfam04826
    Location:1117 → 1303
    Arm_2; Armadillo-like

  3. NM_026081.5 → NP_080357.4  G-protein coupled receptor-associated sorting protein 1

    See identical proteins and their annotated locations for NP_080357.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BB619497, BC058970, BC070413
    Consensus CDS
    CCDS30409.1
    UniProtKB/Swiss-Prot
    A2AGB6, Q5U4C1, Q8BKR8, Q8BUN4, Q8BYK9, Q8CHF4, Q8R095
    Related
    ENSMUSP00000108769.2, ENSMUST00000113144.8
    Conserved Domains (1) summary
    pfam04826
    Location:1117 → 1303
    Arm_2; Armadillo-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    134643441..134704217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U4C1.1 GenPept UniProtKB/Swiss-Prot:Q5U4C1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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