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Ift22 intraflagellar transport 22 [ Mus musculus (house mouse) ]

Gene ID: 67286, updated on 5-Mar-2024

Summary

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Official Symbol
Ift22provided by MGI
Official Full Name
intraflagellar transport 22provided by MGI
Primary source
MGI:MGI:1914536
See related
Ensembl:ENSMUSG00000007987 AllianceGenome:MGI:1914536
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rabl5; 3110017O03Rik
Summary
Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport. Predicted to act upstream of or within intraciliary transport. Located in centrosome and cilium. Part of intraciliary transport particle B. Is expressed in several structures, including adrenal gland; genitourinary system; gut; nervous system; and respiratory system. Orthologous to human IFT22 (intraflagellar transport 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 30.6), frontal lobe adult (RPKM 11.4) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 76.03 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (136937004..136943363)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (136908150..136914509)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene collagen, type XXVI, alpha 1 Neighboring gene VISTA enhancer mm1626 Neighboring gene predicted gene 20485 Neighboring gene predicted gene 43649 Neighboring gene RIKEN cDNA 4933404O12 gene Neighboring gene STARR-seq mESC enhancer starr_14629 Neighboring gene STARR-seq mESC enhancer starr_14631 Neighboring gene STARR-positive B cell enhancer ABC_E10358 Neighboring gene fission, mitochondrial 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3. Liew GM, et al. Dev Cell, 2014 Nov 10. PMID 25443296, Free PMC Article
  2. TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. Ishikawa H, et al. Elife, 2014 Jan 1. PMID 24596149, Free PMC Article
  3. Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex. Katoh Y, et al. J Biol Chem, 2016 May 20. PMID 26980730, Free PMC Article
  4. Characterization of mouse IFT complex B. Follit JA, et al. Cell Motil Cytoskeleton, 2009 Aug. PMID 19253336, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cilium assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary anterograde transport NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within intraciliary transport IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cilium TAS
Traceable Author Statement
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intraciliary transport particle B IDA
Inferred from Direct Assay
more info
 PubMed 
part_of intraciliary transport particle B ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
intraflagellar transport protein 22 homolog
Names
RAB, member of RAS oncogene family-like 5
rab-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026073.3 → NP_080349.1  intraflagellar transport protein 22 homolog

    See identical proteins and their annotated locations for NP_080349.1

    Status: PROVISIONAL

    Source sequence(s)
    AC147987
    Consensus CDS
    CCDS19756.1
    UniProtKB/Swiss-Prot
    Q9DAI2
    UniProtKB/TrEMBL
    A0A0G2JF44
    Related
    ENSMUSP00000143488.2, ENSMUST00000200157.5
    Conserved Domains (2) summary
    COG1100
    Location:1 → 104
    Gem1; GTPase SAR1 family domain [General function prediction only]
    cl21455
    Location:5 → 124
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    136937004..136943363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240905.4 → XP_011239207.1  intraflagellar transport protein 22 homolog isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAI2.1 GenPept UniProtKB/Swiss-Prot:Q9DAI2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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