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SRP19 signal recognition particle 19 [ Homo sapiens (human) ]

Gene ID: 6728, updated on 11-Apr-2024

Summary

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Official Symbol
SRP19provided by HGNC
Official Full Name
signal recognition particle 19provided by HGNC
Primary source
HGNC:HGNC:11300
See related
Ensembl:ENSG00000153037 MIM:182175; AllianceGenome:HGNC:11300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables 7S RNA binding activity. Contributes to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Located in nucleolus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 11.2), bone marrow (RPKM 8.6) and 25 other tissues See more
Orthologs
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Genomic context

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See SRP19 in Genome Data Viewer
Location:
5q22.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (112861287..112898371)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (113371827..113408903)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (112196984..112234068)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene APC regulator of WNT signaling pathway Neighboring gene RNA, U6 small nuclear 482, pseudogene Neighboring gene CBX3 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 9882 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:112226954-112228153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16238 Neighboring gene receptor accessory protein 5 Neighboring gene X-box binding protein 1 pseudogene 1 Neighboring gene ZRSR2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16240 Neighboring gene uncharacterized LOC105379123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22913 Neighboring gene MPRA-validated peak5421 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16241 Neighboring gene Sharpr-MPRA regulatory region 12983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22914 Neighboring gene uncharacterized LOC105379126

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of anti-SRP19 antibody in muscle tissues from patients with autoimmune necrotizing myopathy. Wang Q, et al. Genet Mol Res, 2016 Aug 12. PMID 27525944
  2. Structural insights into the assembly of the human and archaeal signal recognition particles. Wild K, et al. Acta Crystallogr D Biol Crystallogr, 2010 Mar. PMID 20179341
  3. Structure of the SRP19 RNA complex and implications for signal recognition particle assembly. Hainzl T, et al. Nature, 2002 Jun 13. PMID 12050674
  4. Crystal structure of an early protein-RNA assembly complex of the signal recognition particle. Wild K, et al. Science, 2001 Oct 19. PMID 11641499
  5. Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes. Linder MI, et al. Blood, 2023 Feb 9. PMID 36223592, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes.
    Title: Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes.
  2. The crystal structures of the SRP68 protein-binding domain (PBD) in complex with SRP72-PBD and of the SRP72-RBD bound to the SRP S domain (SRP RNA, SRP19 and SRP68) detailing all interactions of SRP72 within SRP have been presented.
    Title: Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction.
  3. anti-SRP19 antibody is highly expressed in muscle tissues of patients with autoimmune necrotizing myopathy.
    Title: Expression of anti-SRP19 antibody in muscle tissues from patients with autoimmune necrotizing myopathy.
  4. crystal structures of a crenarchaeal and the all-human SRP19-signal recognition particle RNA binary complexes presented here show that the asymmetric loop is bulged out in both binary complexes.
    Title: Structural insights into the assembly of the human and archaeal signal recognition particles.
  5. Data show that the presence of SRP54 during SRP19-RNA assembly dramatically alters the folding energy landscape to create a non-native folding pathway that leads to an aberrant SRP19-RNA conformation.
    Title: A threefold RNA-protein interface in the signal recognition particle gates native complex assembly.
  6. Structure of the SRP19 RNA complex
    Title: Structure of the SRP19 RNA complex and implications for signal recognition particle assembly.
  7. crystal structure of a human SRP ternary complex consisting of SRP19, the M domain of SRP54 and the S domain of 7SL RNA
    Title: Induced structural changes of 7SL RNA during the assembly of human signal recognition particle.
  8. 1.8 angstrom resolution crystal structure of human SRP19 in complex with its primary binding site on helix 6 of SRP RNA was determined
    Title: Crystal structure of an early protein-RNA assembly complex of the signal recognition particle.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
nucleocapsid gag Overexpression of SRP19 reduces the HIV-1 NC-mediated packaging of 7SL RNA and A3G into virions in a dose-dependent manner PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 7S RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 7S RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding HDA PubMed 
enables RNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of signal recognition particle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
signal recognition particle 19 kDa protein
Names
signal recognition particle 19kD
signal recognition particle 19kDa
NP_001191122.1
NP_001191123.1
NP_001191125.1
NP_001191128.1
NP_003126.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204193.2 → NP_001191122.1  signal recognition particle 19 kDa protein isoform 2

    See identical proteins and their annotated locations for NP_001191122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AA845342, AC008575, AW890522, BC017830, CN265235
    Consensus CDS
    CCDS56375.1
    UniProtKB/TrEMBL
    A0A087WWU9
    Related
    ENSP00000282999.3, ENST00000282999.7
    Conserved Domains (1) summary
    pfam01922
    Location:17 → 100
    SRP19; SRP19 protein

  2. NM_001204194.2 → NP_001191123.1  signal recognition particle 19 kDa protein isoform 3

    See identical proteins and their annotated locations for NP_001191123.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AA845342, AC008575, AW890522, CN265235, DN915735, X12791
    Consensus CDS
    CCDS75286.1
    UniProtKB/TrEMBL
    A0A087WYR0
    Related
    ENSP00000482018.1, ENST00000621420.5
    Conserved Domains (1) summary
    pfam01922
    Location:17 → 91
    SRP19; SRP19 protein

  3. NM_001204196.2 → NP_001191125.1  signal recognition particle 19 kDa protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon that results in a frameshift in the central and 3' coding regions, compared to variant 1. The encoded isoform (4) has the same N-terminus but is otherwise distinct and shorter, compared to isoform 1.
    Source sequence(s)
    AA845342, AC008575, AW890522, BU661702, CN265235
    Consensus CDS
    CCDS56376.1
    UniProtKB/Swiss-Prot
    P09132
    Related
    ENSP00000425562.1, ENST00000515463.1

  4. NM_001204199.2 → NP_001191128.1  signal recognition particle 19 kDa protein isoform 6

    See identical proteins and their annotated locations for NP_001191128.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 3' coding region and 3' UTR, compared to variant 1, resulting in an isoform (6) with a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC008536, AC008575, DA930867
    Consensus CDS
    CCDS87319.1
    UniProtKB/TrEMBL
    A0A087WWU9, A0A2U3TZN1
    Related
    ENSP00000375133.2, ENST00000391338.3
    Conserved Domains (1) summary
    pfam01922
    Location:17 → 101
    SRP19; SRP19 protein

  5. NM_003135.3 → NP_003126.1  signal recognition particle 19 kDa protein isoform 1

    See identical proteins and their annotated locations for NP_003126.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA845342, AC008575, AW890522, CN265235, X12791
    Consensus CDS
    CCDS4108.1
    UniProtKB/Swiss-Prot
    B2R4E9, D6RCQ5, P09132, Q05D77, Q96FG6
    Related
    ENSP00000424870.1, ENST00000505459.6
    Conserved Domains (1) summary
    pfam01922
    Location:17 → 115
    SRP19; SRP19 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    112861287..112898371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    113371827..113408903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09132.3 GenPept UniProtKB/Swiss-Prot:P09132

Gene LinkOut

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