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Pagr1a PAXIP1 associated glutamate rich protein 1A [ Mus musculus (house mouse) ]

Gene ID: 67278, updated on 5-Mar-2024

Summary

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Official Symbol
Pagr1aprovided by MGI
Official Full Name
PAXIP1 associated glutamate rich protein 1Aprovided by MGI
Primary source
MGI:MGI:1914528
See related
Ensembl:ENSMUSG00000107068 AllianceGenome:MGI:1914528
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PA1; PAGR1; 2900092E17Rik
Summary
Predicted to enable estrogen receptor binding activity. Involved in positive regulation of isotype switching to IgG isotypes; positive regulation of response to DNA damage stimulus; and regulation of cell cycle G2/M phase transition. Acts upstream of or within chorion development and histone H3-K27 demethylation. Part of histone methyltransferase complex. Is expressed in several structures, including extraembryonic component. Orthologous to human PAGR1 (PAXIP1 associated glutamate rich protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 90.4), CNS E11.5 (RPKM 43.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 69.27 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126614223..126616524, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127015051..127017352, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CDP-diacylglycerol--inositol 3-phosphatidyltransferase Neighboring gene major vault protein Neighboring gene STARR-seq mESC enhancer starr_20161 Neighboring gene STARR-positive B cell enhancer ABC_E2850 Neighboring gene proline-rich transmembrane protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134167876-134168063 Neighboring gene predicted gene, 53372 Neighboring gene MYC-associated zinc finger protein (purine-binding transcription factor)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ. Lee JE, et al. Mol Cell Biol, 2020 Aug 14. PMID 32601106, Free PMC Article
  2. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Starnes LM, et al. Genes Dev, 2016 Jan 15. PMID 26744420, Free PMC Article
  3. Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. Gong Z, et al. J Biol Chem, 2009 Mar 13. PMID 19124460, Free PMC Article
  4. UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Wang C, et al. Proc Natl Acad Sci U S A, 2012 Sep 18. PMID 22949634, Free PMC Article
  5. Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development. Kumar A, et al. Dev Dyn, 2014 Jul. PMID 24633704, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPbeta and C/EBPdelta.
    Title: MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.
  2. a PTIP-PA1 subcomplex functions independently from the MLL3/MLL4 complex to mediate transcription during CSR
    Title: A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.
  3. subset of PTIP.PA1 complex is recruited to DNA damage sites via the RNF8-dependent pathway and is required for cell survival in response to DNA damage.
    Title: Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.
  4. PA1 (also known as C16orf53 in human and 2900092E17Rik in mouse) binds PTIP directly and requires PTIP for interaction with the MLL3- and MLL4-containing histone H3 K4 methyltransferase complex.
    Title: PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear estrogen receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chorion development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell cycle G1/S phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intracellular estrogen receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of isotype switching to IgG isotypes IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle G2/M phase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MLL3/4 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MLL3/4 complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone methyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
PAXIP1-associated glutamate-rich protein 1A
Names
PAXIP1-associated glutamate-rich protein 1
PAXIP1-associated protein 1
PTIP-associated 1
PTIP-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030240.1 → NP_084516.1  PAXIP1-associated glutamate-rich protein 1A

    See identical proteins and their annotated locations for NP_084516.1

    Status: PROVISIONAL

    Source sequence(s)
    BC003932
    Consensus CDS
    CCDS21854.1
    UniProtKB/Swiss-Prot
    Q99L02
    Related
    ENSMUSP00000144243.2, ENSMUST00000202798.2
    Conserved Domains (1) summary
    pfam15364
    Location:85 → 216
    PAXIP1_C; PAXIP1-associated-protein-1 C term PTIP binding protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126614223..126616524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99L02.1 GenPept UniProtKB/Swiss-Prot:Q99L02

Gene LinkOut

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