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Mrpl42 mitochondrial ribosomal protein L42 [ Mus musculus (house mouse) ]

Gene ID: 67270, updated on 5-Mar-2024

Summary

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Official Symbol
Mrpl42provided by MGI
Official Full Name
mitochondrial ribosomal protein L42provided by MGI
Primary source
MGI:MGI:1333774
See related
Ensembl:ENSMUSG00000062981 AllianceGenome:MGI:1333774
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L31mt; L42mt; S32mt; PTD007; Rpml31; HSPC204; MRP-L31; MRP-L42; MRP-S32; D10Ertd322e; 2700009F22Rik; 2900055D03Rik
Summary
Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL42 (mitochondrial ribosomal protein L42). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 174.9), kidney adult (RPKM 65.1) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C2; 10 49.39 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (95316667..95337811, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (95480805..95501949, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5730420D15 gene Neighboring gene STARR-seq mESC enhancer starr_27635 Neighboring gene STARR-seq mESC enhancer starr_27638 Neighboring gene STARR-seq mESC enhancer starr_27639 Neighboring gene predicted gene 3619 Neighboring gene predicted gene, 46239 Neighboring gene STARR-seq mESC enhancer starr_27642 Neighboring gene ubiquitin-conjugating enzyme E2N

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Use of denaturing HPLC to map human and murine genes and to validate single-nucleotide polymorphisms. Schriml LM, et al. Biotechniques, 2000 Apr. PMID 10769753
  2. DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos. Wang Y, et al. Nat Commun, 2022 Jul 1. PMID 35778392, Free PMC Article
  3. Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. Goldschmidt-Reisin S, et al. J Biol Chem, 1998 Dec 25. PMID 9857009
  4. Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy. Chern T, et al. Nat Commun, 2022 Jan 10. PMID 35013307, Free PMC Article
  5. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein mL42
Names
28S ribosomal protein L42, mitochondrial
28S ribosomal protein S32, mitochondrial
39S ribosomal protein L31, mitochondrial
39S ribosomal protein L42, mitochondrial
mitochndrial ribosomal protein L42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359476.1 → NP_001346405.1  large ribosomal subunit protein mL42 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AI839395, AK002530, DV050100, DV060222
    Consensus CDS
    CCDS24137.1
    UniProtKB/Swiss-Prot
    Q9CPV3
    Related
    ENSMUSP00000151636.2, ENSMUST00000218893.2
    Conserved Domains (1) summary
    pfam10210
    Location:46 → 142
    MRP-S32; Mitochondrial 28S ribosomal protein S32

  2. NM_001359477.1 → NP_001346406.1  large ribosomal subunit protein mL42 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AI839395, AK002530, AK012227, DV050100, DV060222
    Consensus CDS
    CCDS88076.1
    UniProtKB/TrEMBL
    A0A1W2P6M3, A0A1W2P7E4
    Related
    ENSMUSP00000151315.2, ENSMUST00000217777.2
    Conserved Domains (1) summary
    pfam10210
    Location:46 → 72
    MRP-S32; Mitochondrial 28S ribosomal protein S32

  3. NM_026065.4 → NP_080341.1  large ribosomal subunit protein mL42 isoform 1 precursor

    See identical proteins and their annotated locations for NP_080341.1

    Status: VALIDATED

    Source sequence(s)
    AI839395, AK003427, DV050100, DV060222
    Consensus CDS
    CCDS24137.1
    UniProtKB/Swiss-Prot
    Q9CPV3
    Related
    ENSMUSP00000075226.3, ENSMUST00000075829.3
    Conserved Domains (1) summary
    pfam10210
    Location:46 → 142
    MRP-S32; Mitochondrial 28S ribosomal protein S32

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    95316667..95337811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPV3.1 GenPept UniProtKB/Swiss-Prot:Q9CPV3

Gene LinkOut

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