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Zfp422 zinc finger protein 422 [ Mus musculus (house mouse) ]

Gene ID: 67255, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp422provided by MGI
Official Full Name
zinc finger protein 422provided by MGI
Primary source
MGI:MGI:1914505
See related
Ensembl:ENSMUSG00000059878 AllianceGenome:MGI:1914505
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KOX15; Znf22; Krox25; Krox26; Krox-26; Krox-25-2; 2900028O21Rik
Summary
This gene encodes a putative C2H2 zinc finger transcription factor that may play a role in tooth development. A pseudogene related to this gene is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Broad expression in CNS E11.5 (RPKM 40.6), CNS E14 (RPKM 29.8) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 E3; 6 53.83 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (116600977..116605960, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (116624016..116628999, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57758 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene Ras association (RalGDS/AF-6) domain family member 4 Neighboring gene STARR-seq mESC enhancer starr_17106 Neighboring gene microRNA 7043 Neighboring gene DEPP1 autophagy regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Krox-26 is a novel C2H2 zinc finger transcription factor expressed in developing dental and osteogenic tissues. Ganss B, et al. Connect Tissue Res, 2002. PMID 12489153
  2. The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the locus for permanent tooth agenesis (He-Zhao deficiency). Gao Y, et al. J Dent Res, 2003 Dec. PMID 14630903
  3. Developmental expression pattern and DNA-binding properties of the zinc finger transcription factor Krox-26. Teo W, et al. Connect Tissue Res, 2003. PMID 12952191
  4. Tbx22 expressions during palatal development in fetuses with glucocorticoid-/alcohol-induced C57BL/6N cleft palates. Kim SM, et al. J Craniofac Surg, 2009 Sep. PMID 19816249
  5. Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis. Nie Y, et al. Cell Death Differ, 2020 May. PMID 31685980, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis.
    Title: Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis.
  2. human gene locus mapping assoicated with permanent tooth agenesis
    Title: The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the locus for permanent tooth agenesis (He-Zhao deficiency).
  3. analysis revealed an intense expression of Krox-25 mRNA in rat and mouse teeth; results suggest that Krox-25 plays an important role as a transcription factor for the cytodifferentiation and amelogenesis of enamel epithelium.
    Title: Molecular cloning, chromosomal mapping, and characteristic expression in tooth organ of rat and mouse Krox-25.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in odontogenesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 22
Names
Kruppel type zinc finger protein Krox26
zinc finger protein Krox-25
zinc finger protein Krox-26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302439.1 → NP_001289368.1  zinc finger protein 22

    See identical proteins and their annotated locations for NP_001289368.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK082970, AK152681, AK169251, BY074474
    Consensus CDS
    CCDS20459.1
    UniProtKB/Swiss-Prot
    Q3TF83, Q8VEK7, Q9ERU3
    UniProtKB/TrEMBL
    Q3U7F6
    Related
    ENSMUSP00000084926.3, ENSMUST00000057540.6
    Conserved Domains (2) summary
    COG5048
    Location:53 → 195
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:113 → 133
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001302440.1 → NP_001289369.1  zinc finger protein 22

    See identical proteins and their annotated locations for NP_001289369.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK082970, AK152681, AK169251, BY059739
    Consensus CDS
    CCDS20459.1
    UniProtKB/Swiss-Prot
    Q3TF83, Q8VEK7, Q9ERU3
    UniProtKB/TrEMBL
    Q3U7F6
    Related
    ENSMUSP00000108501.2, ENSMUST00000112880.8
    Conserved Domains (2) summary
    COG5048
    Location:53 → 195
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:113 → 133
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_026057.3 → NP_080333.1  zinc finger protein 22

    See identical proteins and their annotated locations for NP_080333.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK082970, AK152681, AK169251, BY082381
    Consensus CDS
    CCDS20459.1
    UniProtKB/Swiss-Prot
    Q3TF83, Q8VEK7, Q9ERU3
    UniProtKB/TrEMBL
    Q3U7F6
    Related
    ENSMUSP00000078685.6, ENSMUST00000079749.6
    Conserved Domains (2) summary
    COG5048
    Location:53 → 195
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:113 → 133
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    116600977..116605960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255555.2 → XP_030111415.1  zinc finger protein 22 isoform X1

    UniProtKB/Swiss-Prot
    Q3TF83, Q8VEK7, Q9ERU3
    UniProtKB/TrEMBL
    Q3U7F6
    Conserved Domains (2) summary
    COG5048
    Location:53 → 195
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:113 → 133
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERU3.2 GenPept UniProtKB/Swiss-Prot:Q9ERU3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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