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Bmerb1 bMERB domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 67254, updated on 5-Mar-2024

Summary

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Official Symbol
Bmerb1provided by MGI
Official Full Name
bMERB domain containing 1provided by MGI
Primary source
MGI:MGI:1914504
See related
Ensembl:ENSMUSG00000044117 AllianceGenome:MGI:1914504
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MINP; 2900011O08Rik
Summary
Acts upstream of or within negative regulation of cell motility involved in cerebral cortex radial glia guided migration and negative regulation of microtubule depolymerization. Located in microtubule cytoskeleton. Is expressed in several structures, including central nervous system; colon; cornea stroma; glans of male genital tubercle; and peripheral nervous system ganglion. Orthologous to human BMERB1 (bMERB domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 22.3), CNS E18 (RPKM 21.0) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Bmerb1 in Genome Data Viewer
Location:
16 A1; 16 9.66 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (13802975..13922916)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (13986612..14105052)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene pyridoxal-dependent decarboxylase domain containing 1 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40163 Neighboring gene STARR-positive B cell enhancer ABC_E8619 Neighboring gene Mpv17 transgene, kidney disease mutant-like Neighboring gene STARR-seq mESC enhancer starr_40164 Neighboring gene laminin, gamma 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40165 Neighboring gene STARR-seq mESC enhancer starr_40166 Neighboring gene STARR-seq mESC enhancer starr_40168 Neighboring gene STARR-seq mESC enhancer starr_40169 Neighboring gene STARR-seq mESC enhancer starr_40170 Neighboring gene interferon induced transmembrane protein 7 Neighboring gene STARR-seq mESC enhancer starr_40172 Neighboring gene aldo-keto reductase family 1, member B8 pseudogene Neighboring gene high mobility group nucleosome-binding domain-containing protein 5-like Neighboring gene Y box protein 1 pseudogene Neighboring gene meiosis regulator and mRNA stability 1 Neighboring gene STARR-positive B cell enhancer ABC_E7428 Neighboring gene microRNA 484

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The newly identified migration inhibitory protein regulates the radial migration in the developing neocortex. Zhang S, et al. Sci Rep, 2014 Aug 7. PMID 25099998, Free PMC Article
  2. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The newly identified migration inhibitory protein (MINP) regulates the radial migration in the developing neocortex.
    Title: The newly identified migration inhibitory protein regulates the radial migration in the developing neocortex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of cell motility involved in cerebral cortex radial glia guided migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell motility involved in cerebral cortex radial glia guided migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bMERB domain-containing protein 1
Names
migration inhibitory protein
uncharacterized protein C16orf45 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144518.3 → NP_653101.1  bMERB domain-containing protein 1

    See identical proteins and their annotated locations for NP_653101.1

    Status: PROVISIONAL

    Source sequence(s)
    AK136859
    Consensus CDS
    CCDS27971.1
    UniProtKB/Swiss-Prot
    Q3UVX0, Q8R1Y2
    Related
    ENSMUSP00000062758.6, ENSMUST00000056521.12
    Conserved Domains (1) summary
    cl23748
    Location:63 → 142
    DUF3585; Protein of unknown function (DUF3585)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    13802975..13922916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160096.1 → XP_036015989.1  bMERB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UVX0, Q8R1Y2
    Conserved Domains (1) summary
    cl23748
    Location:63 → 142
    DUF3585; Protein of unknown function (DUF3585)

  2. XM_006522482.4 → XP_006522545.1  bMERB domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    cl23748
    Location:9 → 79
    DUF3585; Protein of unknown function (DUF3585)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1Y2.1 GenPept UniProtKB/Swiss-Prot:Q8R1Y2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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