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Resf1 retroelement silencing factor 1 [ Mus musculus (house mouse) ]

Gene ID: 67246, updated on 5-Mar-2024

Summary

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Official Symbol
Resf1provided by MGI
Official Full Name
retroelement silencing factor 1provided by MGI
Primary source
MGI:MGI:1914496
See related
Ensembl:ENSMUSG00000032712 AllianceGenome:MGI:1914496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GET; 2810474O19Rik; 6720435I21Rik
Summary
Enables histone methyltransferase binding activity. Involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate and positive regulation of DNA methylation-dependent heterochromatin assembly. Acts upstream of or within response to bacterium. Located in nucleus. Part of gamma-tubulin complex. Is expressed in limb; reproductive system; somite; and urinary system. Orthologous to human RESF1 (retroelement silencing factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 4.3), ovary adult (RPKM 3.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 G3; 6 78.89 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (149210907..149237161)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (149309409..149335663)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene electron transfer flavoprotein beta subunit lysine methyltransferase Neighboring gene antagonist of mitotic exit network 1 Neighboring gene STARR-seq mESC enhancer starr_17859 Neighboring gene STARR-seq mESC enhancer starr_17860 Neighboring gene STARR-seq mESC enhancer starr_17861 Neighboring gene STARR-seq mESC enhancer starr_17862 Neighboring gene STARR-seq mESC enhancer starr_17863 Neighboring gene STARR-seq mESC enhancer starr_17864 Neighboring gene STARR-seq mESC enhancer starr_17865 Neighboring gene STARR-seq mESC enhancer starr_17866 Neighboring gene STARR-seq mESC enhancer starr_17867 Neighboring gene STARR-seq mESC enhancer starr_17868 Neighboring gene STARR-seq mESC enhancer starr_17869 Neighboring gene STARR-positive B cell enhancer ABC_E8835 Neighboring gene STARR-seq mESC enhancer starr_17870 Neighboring gene STARR-seq mESC enhancer starr_17871 Neighboring gene predicted gene, 38930 Neighboring gene nucleus accumbens associated 1, BEN and BTB (POZ) domain containing pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of Resf1 reduces the efficiency of embryonic stem cell self-renewal and germline entry. Vojtek M, et al. Life Sci Alliance, 2021 Dec. PMID 34607919, Free PMC Article
  2. Conserved expression of a novel gene during gonadal development. Hudson QJ, et al. Dev Dyn, 2005 Jul. PMID 15861396
  3. A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells. Fukuda K, et al. Genome Res, 2018 Jun. PMID 29728365, Free PMC Article
  4. An Oct4-centered protein interaction network in embryonic stem cells. van den Berg DLC, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362541, Free PMC Article
  5. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1551

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone methyltransferase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone methyltransferase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of gamma-tubulin complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
retroelement silencing factor 1
Names
likely orthologue of H. sapiens chromosome 12 open reading frame 35 (C12orf35)
uncharacterized protein C12orf35 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289661.1 → NP_001276590.1  retroelement silencing factor 1

    See identical proteins and their annotated locations for NP_001276590.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC163647, AK020121, BC139436, DV644998
    Consensus CDS
    CCDS20717.1
    UniProtKB/Swiss-Prot
    Q5DTW7, Q5FWH0, Q7TNT1, Q8CCW3, Q8CCZ9, Q9CSA5, Q9CU82
    UniProtKB/TrEMBL
    A0A087WP74, B2KFD2
    Related
    ENSMUSP00000098328.5, ENSMUST00000100765.11
    Conserved Domains (1) summary
    pfam15395
    Location:452 → 1511
    DUF4617; Domain of unknown function (DUF4617)

  2. NM_001289662.1 → NP_001276591.1  retroelement silencing factor 1

    See identical proteins and their annotated locations for NP_001276591.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks an exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC163647, AK020121, BC139435, DV644998
    Consensus CDS
    CCDS20717.1
    UniProtKB/Swiss-Prot
    Q5DTW7, Q5FWH0, Q7TNT1, Q8CCW3, Q8CCZ9, Q9CSA5, Q9CU82
    UniProtKB/TrEMBL
    A0A087WP74, B2KFD2
    Related
    ENSMUSP00000140026.2, ENSMUST00000189932.7
    Conserved Domains (1) summary
    pfam15395
    Location:452 → 1511
    DUF4617; Domain of unknown function (DUF4617)

  3. NM_026054.3 → NP_080330.1  retroelement silencing factor 1

    See identical proteins and their annotated locations for NP_080330.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC163647, AK017376, AK020121, BC139436, DV644998
    Consensus CDS
    CCDS20717.1
    UniProtKB/Swiss-Prot
    Q5DTW7, Q5FWH0, Q7TNT1, Q8CCW3, Q8CCZ9, Q9CSA5, Q9CU82
    UniProtKB/TrEMBL
    A0A087WP74, B2KFD2
    Related
    ENSMUSP00000041180.7, ENSMUST00000046689.13
    Conserved Domains (1) summary
    pfam15395
    Location:452 → 1511
    DUF4617; Domain of unknown function (DUF4617)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    149210907..149237161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507083.4 → XP_006507146.1  retroelement silencing factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006507146.1

    UniProtKB/Swiss-Prot
    Q5DTW7, Q5FWH0, Q7TNT1, Q8CCW3, Q8CCZ9, Q9CSA5, Q9CU82
    UniProtKB/TrEMBL
    A0A087WP74, B2KFD2
    Conserved Domains (1) summary
    pfam15395
    Location:452 → 1511
    DUF4617; Domain of unknown function (DUF4617)

  2. XM_006507081.5 → XP_006507144.1  retroelement silencing factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006507144.1

    UniProtKB/Swiss-Prot
    Q5DTW7, Q5FWH0, Q7TNT1, Q8CCW3, Q8CCZ9, Q9CSA5, Q9CU82
    UniProtKB/TrEMBL
    A0A087WP74, B2KFD2
    Conserved Domains (1) summary
    pfam15395
    Location:452 → 1511
    DUF4617; Domain of unknown function (DUF4617)

  3. XM_006507086.5 → XP_006507149.1  retroelement silencing factor 1 isoform X2

    See identical proteins and their annotated locations for XP_006507149.1

    UniProtKB/TrEMBL
    A0A087WP74
    Conserved Domains (1) summary
    pfam15395
    Location:452 → 1470
    DUF4617; Domain of unknown function (DUF4617)

  4. XM_011241622.3 → XP_011239924.1  retroelement silencing factor 1 isoform X1

    See identical proteins and their annotated locations for XP_011239924.1

    UniProtKB/Swiss-Prot
    Q5DTW7, Q5FWH0, Q7TNT1, Q8CCW3, Q8CCZ9, Q9CSA5, Q9CU82
    UniProtKB/TrEMBL
    A0A087WP74, B2KFD2
    Conserved Domains (1) summary
    pfam15395
    Location:452 → 1511
    DUF4617; Domain of unknown function (DUF4617)

  5. XM_036152270.1 → XP_036008163.1  retroelement silencing factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5DTW7, Q5FWH0, Q7TNT1, Q8CCW3, Q8CCZ9, Q9CSA5, Q9CU82
    UniProtKB/TrEMBL
    A0A087WP74, B2KFD2
    Conserved Domains (1) summary
    pfam15395
    Location:452 → 1511
    DUF4617; Domain of unknown function (DUF4617)

  6. XM_006507084.4 → XP_006507147.1  retroelement silencing factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006507147.1

    UniProtKB/Swiss-Prot
    Q5DTW7, Q5FWH0, Q7TNT1, Q8CCW3, Q8CCZ9, Q9CSA5, Q9CU82
    UniProtKB/TrEMBL
    A0A087WP74, B2KFD2
    Conserved Domains (1) summary
    pfam15395
    Location:452 → 1511
    DUF4617; Domain of unknown function (DUF4617)

  7. XM_030255554.2 → XP_030111414.1  retroelement silencing factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5DTW7, Q5FWH0, Q7TNT1, Q8CCW3, Q8CCZ9, Q9CSA5, Q9CU82
    UniProtKB/TrEMBL
    A0A087WP74, B2KFD2
    Related
    ENSMUSP00000139660.2, ENSMUST00000189837.2
    Conserved Domains (1) summary
    pfam15395
    Location:452 → 1511
    DUF4617; Domain of unknown function (DUF4617)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DTW7.2 GenPept UniProtKB/Swiss-Prot:Q5DTW7

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