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Cinp cyclin dependent kinase 2 interacting protein [ Mus musculus (house mouse) ]

Gene ID: 67236, updated on 5-Mar-2024

Summary

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Official Symbol
Cinpprovided by MGI
Official Full Name
cyclin dependent kinase 2 interacting proteinprovided by MGI
Primary source
MGI:MGI:1914486
See related
Ensembl:ENSMUSG00000021276 AllianceGenome:MGI:1914486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810047K05Rik; 2810452K22Rik
Summary
Predicted to act upstream of or within DNA repair; DNA replication; and cell division. Predicted to be located in nucleus. Is expressed in axial musculature; ganglia; incisor; medulla oblongata basal plate mantle layer; and submandibular gland primordium. Orthologous to human CINP (cyclin dependent kinase 2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 13.4), CNS E18 (RPKM 12.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cinp in Genome Data Viewer
Location:
12 F1; 12 60.85 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (110839044..110855579, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (110872610..110889145, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4044 Neighboring gene nuclear encoded tRNA isoleucine 6 (anticodon AAT) Neighboring gene zinc finger protein 839 Neighboring gene mitochondrial pyruvate carrier 1, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1157 Neighboring gene tectonin beta-propeller repeat containing 2 Neighboring gene ribosomal protein S19, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_33311 Neighboring gene ankyrin repeat domain 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables preribosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 2-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026048.4 → NP_080324.1  cyclin-dependent kinase 2-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_080324.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. It encodes isoform 1.
    Source sequence(s)
    AC101875, AK076126, BB761424
    Consensus CDS
    CCDS36561.1
    UniProtKB/Swiss-Prot
    Q8C063, Q9D0V8, Q9D8P9
    Related
    ENSMUSP00000035245.9, ENSMUST00000043716.9

  2. NM_027223.1 → NP_081499.1  cyclin-dependent kinase 2-interacting protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform 2, which is longer than isoform 1.
    Source sequence(s)
    AC101875
    Consensus CDS
    CCDS88405.1
    UniProtKB/TrEMBL
    A0A1Y7VN75
    Related
    ENSMUSP00000152272.2, ENSMUST00000220607.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    110839044..110855579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0V8.1 GenPept UniProtKB/Swiss-Prot:Q9D0V8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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