Plekho1 pleckstrin homology domain containing, family O member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plekho1provided by MGI
Official Full Name: pleckstrin homology domain containing, family O member 1provided by MGI
Primary source: MGI:MGI:1914470
See related: Ensembl:ENSMUSG00000015745 AllianceGenome:MGI:1914470
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Jza2; Ckip1; CKIP-1; JZA-20; 2810052M02Rik
Summary: Acts upstream of or within several processes, including lamellipodium morphogenesis; myoblast fusion; and myoblast migration. Located in muscle cell projection membrane and ruffle membrane. Orthologous to human PLEKHO1 (pleckstrin homology domain containing O1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 51.0), CNS E11.5 (RPKM 47.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 41.65 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (95896110..95903258, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (95988809..95999355, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CKIP-1 Promotes P. gingivalis-Induced Inflammation of Periodontal Soft Tissues by Inhibiting Autophagy.
Title: CKIP-1 Promotes P. gingivalis-Induced Inflammation of Periodontal Soft Tissues by Inhibiting Autophagy.
[Effect of CKIP-1 on hepatocyte apoptosis in nonalcoholic fatty liver disease].
Title: [Effect of CKIP-1 on hepatocyte apoptosis in nonalcoholic fatty liver disease].
The ubiquitination of CKIP-1 mediated by Src aggravates diabetic renal fibrosis (original article).
Title: The ubiquitination of CKIP-1 mediated by Src aggravates diabetic renal fibrosis (original article).
Ckip-1 Mediates P. gingivalis-Suppressed Cementoblast Mineralization.
Title: Ckip-1 Mediates P. gingivalis-Suppressed Cementoblast Mineralization.
CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
Title: CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
CKIP-1 contributes to osteogenic differentiation of mouse bone marrow mesenchymal stem cells.
Title: CKIP-1 contributes to osteogenic differentiation of mouse bone marrow mesenchymal stem cells.
3' untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein.
Title: 3' untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein.
Inflammation-mediated age-dependent effects of casein kinase 2-interacting protein-1 on osteogenesis in mesenchymal stem cells.
Title: Inflammation-mediated age-dependent effects of casein kinase 2-interacting protein-1 on osteogenesis in mesenchymal stem cells.
CKIP-1 augments autophagy in steatotic hepatocytes by inhibiting Akt/mTOR signal pathway.
Title: CKIP-1 augments autophagy in steatotic hepatocytes by inhibiting Akt/mTOR signal pathway.
Superior CKIP-1 sensitivity of orofacial bone-derived mesenchymal stem cells in proliferation and osteogenic differentiation compared to long bone-derived mesenchymal stem cells.
Title: Superior CKIP-1 sensitivity of orofacial bone-derived mesenchymal stem cells in proliferation and osteogenic differentiation compared to long bone-derived mesenchymal stem cells.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within lamellipodium morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lamellipodium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myoblast fusion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myoblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell shape	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myoblast fusion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in muscle cell projection membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in muscle cell projection membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in ruffle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pleckstrin homology domain-containing family O member 1

Names: CK2 interacting protein 1; Jun zipper-associated 2; PH domain-containing family O member 1; TNF intracellular domain-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418048.1 → NP_001404977.1 pleckstrin homology domain-containing family O member 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC092855
NM_023320.3 → NP_075809.1 pleckstrin homology domain-containing family O member 1 isoform 1

See identical proteins and their annotated locations for NP_075809.1

Status: VALIDATED

Source sequence(s)

AC092855

Consensus CDS

CCDS17627.1

UniProtKB/Swiss-Prot

Q9CXH2, Q9JIY0

UniProtKB/TrEMBL

F6XQM2

Related

ENSMUSP00000015889.4, ENSMUST00000015889.10

Conserved Domains (2) summary

cd13317
Location:17 → 126

PH_PLEKHO1_PLEKHO2; Pleckstrin homology domain-containing family O Pleckstrin homology domain

pfam00169
Location:25 → 130

PH; PH domain