U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Glod4 glyoxalase domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 67201, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Glod4provided by MGI
Official Full Name
glyoxalase domain containing 4provided by MGI
Primary source
MGI:MGI:1914451
See related
Ensembl:ENSMUSG00000017286 AllianceGenome:MGI:1914451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700082G03Rik; 2700085E05Rik
Summary
Located in mitochondrion. Orthologous to human GLOD4 (glyoxalase domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.6), bladder adult (RPKM 8.2) and 26 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 B5; 11 45.92 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (76111221..76134525, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (76220395..76243699, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8426 Neighboring gene STARR-seq mESC enhancer starr_30015 Neighboring gene gem nuclear organelle associated protein 4 Neighboring gene diazepam binding inhibitor-like 5 Neighboring gene STARR-positive B cell enhancer ABC_E7019 Neighboring gene mitochondrial rRNA methyltransferase 3 Neighboring gene nucleoredoxin Neighboring gene STARR-seq mESC enhancer starr_30020 Neighboring gene STARR-seq mESC enhancer starr_30022 Neighboring gene STARR-seq mESC enhancer starr_30023 Neighboring gene STARR-seq mESC enhancer starr_30026

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease. Cozzolino F, et al. Hum Mol Genet, 2021 Jun 17. PMID 33601422
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Potential readthrough

Included gene: Vps53

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
glyoxalase domain-containing protein 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362901.1 → NP_001349830.1  glyoxalase domain-containing protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591129
    Consensus CDS
    CCDS88193.1
    UniProtKB/TrEMBL
    E9Q197
    Related
    ENSMUSP00000131788.2, ENSMUST00000170710.8
    Conserved Domains (2) summary
    cd16357
    Location:121 → 236
    GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
    cl14632
    Location:12 → 111
    VOC; vicinal oxygen chelate (VOC) family

  2. NM_026029.3 → NP_080305.2  glyoxalase domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_080305.2

    Status: VALIDATED

    Source sequence(s)
    AI450701, AL591129, BC061012, BY122171, CF950671
    Consensus CDS
    CCDS25063.1
    UniProtKB/Swiss-Prot
    Q3UUS8, Q9CPV4, Q9CY26, Q9D9F5
    UniProtKB/TrEMBL
    E9Q197
    Related
    ENSMUSP00000017430.6, ENSMUST00000017430.12
    Conserved Domains (3) summary
    cd08358
    Location:4 → 130
    Glo_EDI_BRP_like_21; This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases
    cd06587
    Location:141 → 255
    Glo_EDI_BRP_like; This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins
    PLN02300
    Location:4 → 264
    PLN02300; lactoylglutathione lyase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    76111221..76134525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPV4.1 GenPept UniProtKB/Swiss-Prot:Q9CPV4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous