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Zcrb1 zinc finger CCHC-type and RNA binding motif 1 [ Mus musculus (house mouse) ]

Gene ID: 67197, updated on 5-Mar-2024

Summary

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Official Symbol
Zcrb1provided by MGI
Official Full Name
zinc finger CCHC-type and RNA binding motif 1provided by MGI
Primary source
MGI:MGI:1914447
See related
Ensembl:ENSMUSG00000022635 AllianceGenome:MGI:1914447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Madp-1; 2700088M22Rik
Summary
Predicted to enable RNA binding activity and zinc ion binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleus. Predicted to be part of U12-type spliceosomal complex. Is expressed in central nervous system and sensory organ. Orthologous to human ZCRB1 (zinc finger CCHC-type and RNA binding motif containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 46.2), CNS E14 (RPKM 26.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E3; 15 47.53 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (93283987..93296218, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (93386106..93398341, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene YY1 associated factor 2 Neighboring gene predicted gene, 52193 Neighboring gene predicted gene, 26371 Neighboring gene STARR-seq mESC enhancer starr_39524 Neighboring gene STARR-positive B cell enhancer ABC_E11788 Neighboring gene periphilin 1 Neighboring gene predicted gene, 30181 Neighboring gene STARR-seq mESC enhancer starr_39526 Neighboring gene STARR-seq mESC enhancer starr_39528 Neighboring gene STARR-seq mESC enhancer starr_39531 Neighboring gene prickle planar cell polarity protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:93382836-93383019 Neighboring gene STARR-seq mESC enhancer starr_39536 Neighboring gene STARR-seq mESC enhancer starr_39537

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation, expression, and characterization of the human ZCRB1 gene mapped to 12q12. Wang H, et al. Genomics, 2007 Jan. PMID 16959469
  2. Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Horiuchi K, et al. Cell Rep, 2018 Apr 3. PMID 29617656
  3. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U12-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U12-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger CCHC-type and RNA-binding motif-containing protein 1
Names
U11/U12 small nuclear ribonucleoprotein 31 kDa protein
U11/U12 snRNP 31 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347097.1 → NP_001334026.1  zinc finger CCHC-type and RNA-binding motif-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126556, AI325876, AI666574
    Consensus CDS
    CCDS84190.1
    UniProtKB/Swiss-Prot
    Q9CZ96
    Related
    ENSMUSP00000124549.2, ENSMUST00000162160.8

  2. NM_026025.3 → NP_080301.1  zinc finger CCHC-type and RNA-binding motif-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_080301.1

    Status: VALIDATED

    Source sequence(s)
    AC126556, AI666574, AK012852
    Consensus CDS
    CCDS27766.1
    UniProtKB/Swiss-Prot
    Q3TDL3, Q9CZ96
    Related
    ENSMUSP00000075441.3, ENSMUST00000076070.9
    Conserved Domains (2) summary
    PTZ00368
    Location:97 → 123
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    cd12393
    Location:9 → 84
    RRM_ZCRB1; RNA recognition motif (RRM) found in Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (ZCRB1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    93283987..93296218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245713.4 → XP_011244015.1  zinc finger CCHC-type and RNA-binding motif-containing protein 1 isoform X1

    Conserved Domains (2) summary
    PTZ00368
    Location:56 → 82
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    cl17169
    Location:1 → 45
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_030248711.2 → XP_030104571.1  zinc finger CCHC-type and RNA-binding motif-containing protein 1 isoform X2

    Conserved Domains (2) summary
    PTZ00368
    Location:56 → 82
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    cl17169
    Location:1 → 45
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZ96.1 GenPept UniProtKB/Swiss-Prot:Q9CZ96

Gene LinkOut

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