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Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 [ Mus musculus (house mouse) ]

Gene ID: 67184, updated on 16-Apr-2024

Summary

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Official Symbol
Ndufa13provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase subunit A13provided by MGI
Primary source
MGI:MGI:1914434
See related
Ensembl:ENSMUSG00000036199 AllianceGenome:MGI:1914434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDA016; CGI-39; Grim19; GRIM-19; CI-B16.6; 2700054G14Rik
Summary
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Acts upstream of or within extrinsic apoptotic signaling pathway. Located in mitochondrion and nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 28 and thyroid gland Hurthle cell carcinoma. Orthologous to several human genes including NDUFA13 (NADH:ubiquinone oxidoreductase subunit A13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 81.9), testis adult (RPKM 75.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B3.3; 8 34.03 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70346813..70355208, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69894163..69902558, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33746 Neighboring gene cartilage intermediate layer protein 2 Neighboring gene YjeF N-terminal domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E10503 Neighboring gene STARR-positive B cell enhancer ABC_E1757 Neighboring gene testis-specific serine kinase 6 Neighboring gene GATA zinc finger domain containing 2A Neighboring gene STARR-positive B cell enhancer ABC_E5012 Neighboring gene STARR-positive B cell enhancer ABC_E1367 Neighboring gene STARR-seq mESC enhancer starr_21753 Neighboring gene STARR-seq mESC enhancer starr_21758 Neighboring gene STARR-positive B cell enhancer ABC_E89 Neighboring gene STARR-seq mESC enhancer starr_21762 Neighboring gene nucleoside diphosphate kinase B pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Grim-19 plays a key role in mitochondrial steroidogenic acute regulatory protein stability and ligand-binding properties in Leydig cells. Qu H, et al. J Biol Chem, 2022 Dec. PMID 36334625, Free PMC Article
  2. The effect and mechanism of Grim 19 on mouse sperm quality and testosterone synthesis. Zhao Y, et al. Reproduction, 2022 May 19. PMID 35312628
  3. GRIM19 is involved in WT1 expression and epithelial-to-mesenchymal transition in adenomyotic lesions. Geng C, et al. Reproduction, 2021 Oct 7. PMID 34590585
  4. GRIM19 Impedes Obesity by Regulating Inflammatory White Fat Browning and Promoting Th17/Treg Balance. Jhun J, et al. Cells, 2021 Jan 15. PMID 33467683, Free PMC Article
  5. Heterogeneity of GRIM-19 Expression in the Adult Mouse Brain. Hwang SN, et al. Cell Mol Neurobiol, 2019 Oct. PMID 31111264

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GRIM19 deficiency aggravates metabolic disorder and ovarian dysfunction in PCOS.
    Title: GRIM19 deficiency aggravates metabolic disorder and ovarian dysfunction in PCOS.
  2. Grim-19 plays a key role in mitochondrial steroidogenic acute regulatory protein stability and ligand-binding properties in Leydig cells.
    Title: Grim-19 plays a key role in mitochondrial steroidogenic acute regulatory protein stability and ligand-binding properties in Leydig cells.
  3. Grim-19 deficiency promotes decidual macrophage autophagy in recurrent spontaneous abortion.
    Title: Grim-19 deficiency promotes decidual macrophage autophagy in recurrent spontaneous abortion.
  4. The effect and mechanism of Grim 19 on mouse sperm quality and testosterone synthesis.
    Title: The effect and mechanism of Grim 19 on mouse sperm quality and testosterone synthesis.
  5. GRIM19 is involved in WT1 expression and epithelial-to-mesenchymal transition in adenomyotic lesions.
    Title: GRIM19 is involved in WT1 expression and epithelial-to-mesenchymal transition in adenomyotic lesions.
  6. GRIM-19 is a target of mycobacterial Zn(2+) metalloprotease 1 and indispensable for NLRP3 inflammasome activation.
    Title: GRIM-19 is a target of mycobacterial Zn(2+) metalloprotease 1 and indispensable for NLRP3 inflammasome activation.
  7. GRIM19 Impedes Obesity by Regulating Inflammatory White Fat Browning and Promoting Th17/Treg Balance.
    Title: GRIM19 Impedes Obesity by Regulating Inflammatory White Fat Browning and Promoting Th17/Treg Balance.
  8. the present study examined the distribution patterns of GRIM-19 in the adult C57BL/6 mouse brain
    Title: Heterogeneity of GRIM-19 Expression in the Adult Mouse Brain.
  9. The protein and mRNA levels of GRIM-19 were markedly decreased on Day 4 of pregnancy, but there was no change in GRIM-19 levels in a group of pseudopregnant mice. Overexpression of GRIM-19 decreased the adhesion rate of RL95-2-BeWo co-cultured spheroids and increased apoptosis.
    Title: GRIM-19, a gene associated with retinoid-interferon-induced mortality, affects endometrial receptivity and embryo implantation.
  10. At the basal state, a moderate down-regulation of NDUFA13 created a leak within complex I, resulting in a mild increase in cytoplasm localized Hydrogen Peroxide, but not superoxide. The resultant reactive oxygen species served as a second messenger and was responsible for the STAT3 dimerization and, hence, the activation of antiapoptotic signaling.
    Title: Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in aerobic respiration NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein insertion into mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial respirasome ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
Names
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NADH-ubiquinone oxidoreductase B16.6 subunit
cell death regulatory protein GRIM-19
complex I-B16.6
gene associated with retinoic and IFN-induced mortality 19 protein
gene associated with retinoic and interferon-induced mortality 19 protein
gene associated with retinoic-interferon-induced mortality 19 protein
genes associated with retinoid-IFN-induced mortality 19
NP_001369144.1
NP_001408485.1
NP_075801.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382215.1 → NP_001369144.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

    Status: VALIDATED

    Source sequence(s)
    AC158564
    UniProtKB/Swiss-Prot
    Q9DC98, Q9DCA1, Q9ERS2
    Conserved Domains (1) summary
    pfam06212
    Location:5 → 128
    GRIM-19; GRIM-19 protein

  2. NM_001421556.1 → NP_001408485.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

    Status: VALIDATED

    Source sequence(s)
    AC158564
    UniProtKB/Swiss-Prot
    Q9DC98, Q9DCA1, Q9ERS2

  3. NM_023312.3 → NP_075801.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

    See identical proteins and their annotated locations for NP_075801.1

    Status: VALIDATED

    Source sequence(s)
    AC158564
    Consensus CDS
    CCDS22353.1
    UniProtKB/Swiss-Prot
    Q9DC98, Q9DCA1, Q9ERS2
    Related
    ENSMUSP00000105796.4, ENSMUST00000110167.5
    Conserved Domains (1) summary
    pfam06212
    Location:5 → 128
    GRIM-19; GRIM-19 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70346813..70355208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERS2.3 GenPept UniProtKB/Swiss-Prot:Q9ERS2

Gene LinkOut

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