U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pdzk1ip1 PDZK1 interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 67182, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Pdzk1ip1provided by MGI
Official Full Name
PDZK1 interacting protein 1provided by MGI
Primary source
MGI:MGI:1914432
See related
Ensembl:ENSMUSG00000028716 AllianceGenome:MGI:1914432
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Map17; 0610007F13Rik; 2700030M23Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including central nervous system; dorsal aorta; metanephros; naris; and retina. Orthologous to human PDZK1IP1 (PDZK1 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 657.0), colon adult (RPKM 64.0) and 3 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 D1; 4 52.75 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (114945905..114951091)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115088708..115093894)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52674 Neighboring gene predicted gene, 33786 Neighboring gene T cell acute lymphocytic leukemia 1 Neighboring gene cytochrome P450, family 4, subfamily x, polypeptide 1 Neighboring gene cytochrome P450, family 4, subfamily x, polypeptide 1, opposite strand Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 28, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Systematic analysis of a simple adaptor protein PDZK1: ligand identification, interaction and functional prediction of complex. Hu S, et al. Cell Physiol Biochem, 2009. PMID 19710538
  2. Interaction of MAP17 with NHERF3/4 induces translocation of the renal Na/Pi IIa transporter to the trans-Golgi. Lanaspa MA, et al. Am J Physiol Renal Physiol, 2007 Jan. PMID 16926447
  3. PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and suppresses transforming growth factor-β (TGF-β) signaling. Ikeno S, et al. J Biol Chem, 2019 Mar 29. PMID 30718277, Free PMC Article
  4. Knockout mouse models for intestinal electrolyte transporters and regulatory PDZ adaptors: new insights into cystic fibrosis, secretory diarrhoea and fructose-induced hypertension. Seidler U, et al. Exp Physiol, 2009 Feb. PMID 18931049
  5. Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels. Silver DL, et al. J Biol Chem, 2003 Aug 1. PMID 12754212

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings indicate that PDZK1IP1 interacts with Smad4 and thereby suppresses the TGF-beta signaling pathway.
    Title: PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and suppresses transforming growth factor-β (TGF-β) signaling.
  2. Systematic analysis of Pdzk1ip1 is reported.
    Title: Systematic analysis of a simple adaptor protein PDZK1: ligand identification, interaction and functional prediction of complex.
  3. Knockout mice for 3 members of the sodium-hydrogen regulatory factor (NHERF) family of PDZ adaptor proteins, NHERF1 (EBP50), NHERF2 (E3KARP) and NHERF3 (PDZK1), have helped to show that NHERF1 is essential for both normal and mutant CFTR function [review]
    Title: Knockout mouse models for intestinal electrolyte transporters and regulatory PDZ adaptors: new insights into cystic fibrosis, secretory diarrhoea and fructose-induced hypertension.
  4. MAP17 1) interacts with PDZK1 only, 2) associates with the NH2 terminus of NaPi-IIa within the PDZK1/NaPi-IIa/MAP17 complex, and 3) acts as an apical anchoring site for PDZK1.
    Title: Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells.
  5. membrane associated protein 17 may be an endogenous regulator of cellular PDZ domain containing 1(PDZK1) levels by regulating PDZK1 turnover
    Title: Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels.
  6. the interaction between MAP17, NHERF3/4, and NaPiIIa in the trans-Golgi network could be an important intermediate or alternate path in the internalization of NaPiIIa
    Title: Interaction of MAP17 with NHERF3/4 induces translocation of the renal Na/Pi IIa transporter to the trans-Golgi.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
PDZK1-interacting protein 1
Names
17 kDa membrane-associated protein
membrane-associated protein 17 (Map17)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164557.1 → NP_001158029.1  PDZK1-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001158029.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK007936, AL670035, DV058382, EH108199
    Consensus CDS
    CCDS51272.1
    UniProtKB/TrEMBL
    G3UW41
    Related
    ENSMUSP00000128118.2, ENSMUST00000171877.8
    Conserved Domains (1) summary
    pfam15807
    Location:84 → 181
    MAP17; Membrane-associated protein 117 kDa, PDZK1-interacting protein 1

  2. NM_001164558.1 → NP_001158030.1  PDZK1-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001158030.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a segment of the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AL645473, AL670035, DV057288, DV058382
    Consensus CDS
    CCDS18487.1
    UniProtKB/Swiss-Prot
    Q9CQH0
    UniProtKB/TrEMBL
    A8C1X3
    Related
    ENSMUSP00000136049.2, ENSMUST00000177647.8
    Conserved Domains (1) summary
    pfam15807
    Location:6 → 114
    MAP17; Membrane-associated protein 117 kDa, PDZK1-interacting protein 1

  3. NM_026018.3 → NP_080294.1  PDZK1-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_080294.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment of the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK008253, AL670035, DV058382
    Consensus CDS
    CCDS18487.1
    UniProtKB/Swiss-Prot
    Q9CQH0
    UniProtKB/TrEMBL
    A8C1X3
    Related
    ENSMUSP00000102158.3, ENSMUST00000106548.9
    Conserved Domains (1) summary
    pfam15807
    Location:6 → 114
    MAP17; Membrane-associated protein 117 kDa, PDZK1-interacting protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    114945905..114951091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253719.2 → XP_030109579.1  PDZK1-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9CQH0
    UniProtKB/TrEMBL
    A8C1X3
    Conserved Domains (1) summary
    pfam15807
    Location:6 → 114
    MAP17; Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQH0.1 GenPept UniProtKB/Swiss-Prot:Q9CQH0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous