Arl8b ADP-ribosylation factor-like 8B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arl8bprovided by MGI
Official Full Name: ADP-ribosylation factor-like 8Bprovided by MGI
Primary source: MGI:MGI:1914416
See related: Ensembl:ENSMUSG00000030105 AllianceGenome:MGI:1914416
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: gie1; Arl10c; 2610313E07Rik; 3100002J04Rik
Summary: Predicted to enable guanyl ribonucleotide binding activity and tubulin binding activity. Involved in several processes, including antigen processing and presentation of polysaccharide antigen via MHC class II; late endosome to lysosome transport; and viral exocytosis. Acts upstream of or within endosomal transport. Located in axon; lysosome; and synapse. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and skin. Orthologous to human ARL8B (ADP ribosylation factor like GTPase 8B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 29.8), cortex adult (RPKM 29.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E2; 6 49.87 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (108760020..108800684)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (108783059..108823723)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arl8b mediates lysosomal degradation of maternal proteins in the visceral yolk sac endoderm, thereby contributing to mouse embryonic development.
Title: Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos.
MHC class II presentation is controlled by the lysosomal Arl8b.
Title: MHC class II presentation is controlled by the lysosomal small GTPase, Arl8b.
Arl8B is required for LPS-stimulated lysosome tubulation in macrophages.
Title: Rab7 and Arl8 GTPases are necessary for lysosome tubulation in macrophages.
Arl8B plays an important role of Arl8B in neurite formation.
Title: Expression of ADP-ribosylation factor-like protein 8B mRNA in the brain is down-regulated in mice fed a high-fat diet.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	ISO Inferred from Sequence Orthology more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterograde axonal transport	IDA Inferred from Direct Assay more info	PubMed
involved_in antigen processing and presentation following phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in antigen processing and presentation of polysaccharide antigen via MHC class II	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagosome-lysosome fusion	ISO Inferred from Sequence Orthology more info
involved_in calcium ion regulated lysosome exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endosomal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome to lysosome transport of low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
involved_in late endosome to lysosome transport	IDA Inferred from Direct Assay more info	PubMed
involved_in late endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in phagosome-lysosome fusion	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in viral exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in viral exocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytolytic granule membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in spindle midzone	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ADP-ribosylation factor-like protein 8B

Names: ADP-ribosylation factor-like 10C; ADP-ribosylation factor-like protein 10C; novel small G protein indispensable for equal chromosome segregation 1; small G protein indispensable for equal chromosome segregation 1

NP_080287.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.