Rnf212 ring finger protein 212 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf212provided by MGI
Official Full Name: ring finger protein 212provided by MGI
Primary source: MGI:MGI:3645767
See related: Ensembl:ENSMUSG00000055385 AllianceGenome:MGI:3645767
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: repro57; EG330157; F830003B07
Summary: Predicted to enable SUMO transferase activity. Involved in chiasma assembly and meiotic gene conversion. Colocalizes with synaptonemal complex. Orthologous to human RNF212 (ring finger protein 212). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 2.5), colon adult (RPKM 0.7) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 53.24 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (108875971..108922933, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (108728105..108775067, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interdependent localization of SUMO, ubiquitin, and proteasomes along chromosome axes was mediated largely by RNF212 and HEI10, two E3 ligases that are also essential for crossover recombination.
Title: A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination.
Mutation in the mouse Rnf212 gene is associated with male meiotic failure and infertility.
Title: An ENU-induced mutation in the mouse Rnf212 gene is associated with male meiotic failure and infertility.
Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination.
Title: Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination.
We show that mouse RNF212 is essential for crossing-over, functioning to couple chromosome synapsis to the formation of crossover-specific recombination complexes
Title: RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SUMO transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables SUMO transferase activity	NAS Non-traceable Author Statement more info	PubMed
enables SUMO transferase activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chiasma assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homologous chromosome pairing at meiosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic gene conversion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein sumoylation	NAS Non-traceable Author Statement more info	PubMed
involved_in protein sumoylation	TAS Traceable Author Statement more info	PubMed
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
colocalizes_with synaptonemal complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: probable E3 SUMO-protein ligase RNF212

Names: probable E3 SUMO-protein transferase RNF212

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362887.1 → NP_001349816.1 probable E3 SUMO-protein ligase RNF212

Status: VALIDATED

Source sequence(s)

AC123743

Consensus CDS

CCDS89962.1

UniProtKB/Swiss-Prot

F6TQD1, Q8BN46

Related

ENSMUSP00000148758.2, ENSMUST00000212212.2

Conserved Domains (3) summary

PHA03247
Location:148 → 300

PHA03247; large tegument protein UL36; Provisional

COG4098
Location:6 → 113

comFA; Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, recombination and repair]

cd16746
Location:4 → 50

RING-HC_RNF212; RING finger, HC subclass, found in RING finger protein 212 (RNF212) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

108875971..108922933 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535331.4 → XP_006535394.1 probable E3 SUMO-protein ligase RNF212 isoform X1

Conserved Domains (4) summary

PHA03247
Location:148 → 300

PHA03247; large tegument protein UL36; Provisional

COG4098
Location:6 → 113

comFA; Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, recombination and repair]

cd00162
Location:7 → 45

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

cl17238
Location:4 → 50

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_006535332.3 → XP_006535395.1 probable E3 SUMO-protein ligase RNF212 isoform X2

UniProtKB/TrEMBL

A0A0G2JDH3

Related

ENSMUSP00000142368.2, ENSMUST00000197384.5