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Mtdh metadherin [ Mus musculus (house mouse) ]

Gene ID: 67154, updated on 21-Apr-2024

Summary

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Official Symbol
Mtdhprovided by MGI
Official Full Name
metadherinprovided by MGI
Primary source
MGI:MGI:1914404
See related
Ensembl:ENSMUSG00000022255 AllianceGenome:MGI:1914404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3D3; AEG-1; Lyric; 3D3/Lyric; D8Bwg1112e; 2610103J23Rik
Summary
Predicted to enable NF-kappaB binding activity; double-stranded RNA binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of intracellular signal transduction; and regulation of transcription, DNA-templated. Located in endoplasmic reticulum membrane; nucleolus; and perinuclear region of cytoplasm. Is expressed in several structures, including brain; genitourinary system; limb primordium; nose; and skin. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MTDH (metadherin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 15.3), bladder adult (RPKM 13.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 B3.1; 15 13.98 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (34082613..34143683)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (34082442..34143537)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38315 Neighboring gene predicted gene 9643 Neighboring gene predicted gene, 41290 Neighboring gene STARR-positive B cell enhancer ABC_E8585 Neighboring gene STARR-positive B cell enhancer ABC_E9909 Neighboring gene STARR-positive B cell enhancer ABC_E10848 Neighboring gene STARR-seq mESC enhancer starr_38319 Neighboring gene STARR-seq mESC enhancer starr_38320 Neighboring gene predicted gene, 41291 Neighboring gene predicted gene, 38594 Neighboring gene STARR-seq mESC enhancer starr_38323 Neighboring gene STARR-seq mESC enhancer starr_38324 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:34167683-34167792 Neighboring gene STARR-seq mESC enhancer starr_38325 Neighboring gene lysosomal-associated protein transmembrane 4B Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dissecting the Balance Between Metabolic and Oncogenic Functions of Astrocyte-Elevated Gene-1/Metadherin. Rajesh Y, et al. Hepatol Commun, 2022 Mar. PMID 34741448, Free PMC Article
  2. Micheliolide ameliorates renal fibrosis by suppressing the Mtdh/BMP/MAPK pathway. Peng F, et al. Lab Invest, 2019 Jul. PMID 30976056, Free PMC Article
  3. A novel role of astrocyte elevated gene-1 (AEG-1) in regulating nonalcoholic steatohepatitis (NASH). Srivastava J, et al. Hepatology, 2017 Aug. PMID 28437865, Free PMC Article
  4. Metadherin facilitates podocyte apoptosis in diabetic nephropathy. Liu WT, et al. Cell Death Dis, 2016 Nov 24. PMID 27882943, Free PMC Article
  5. Astrocyte Elevated Gene-1 (AEG-1) Regulates Lipid Homeostasis. Robertson CL, et al. J Biol Chem, 2015 Jul 17. PMID 26070567, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of Granule Cell Dispersion and Seizure Development by Astrocyte Elevated Gene-1 in a Mouse Model of Temporal Lobe Epilepsy.
    Title: Inhibition of Granule Cell Dispersion and Seizure Development by Astrocyte Elevated Gene-1 in a Mouse Model of Temporal Lobe Epilepsy.
  2. Metadherin orchestrates PKA and PKM2 to activate beta-catenin signaling in podocytes during proteinuric chronic kidney disease.
    Title: Metadherin orchestrates PKA and PKM2 to activate β-catenin signaling in podocytes during proteinuric chronic kidney disease.
  3. Expression patterns of AEG-1 in the normal brain.
    Title: Expression patterns of AEG-1 in the normal brain.
  4. Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity.
    Title: Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity.
  5. Dissecting the Balance Between Metabolic and Oncogenic Functions of Astrocyte-Elevated Gene-1/Metadherin.
    Title: Dissecting the Balance Between Metabolic and Oncogenic Functions of Astrocyte-Elevated Gene-1/Metadherin.
  6. Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis.
    Title: Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis.
  7. The Scope of Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH) in Cancer Clinicopathology: A Review.
    Title: The Scope of Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH) in Cancer Clinicopathology: A Review.
  8. A novel metadherinDelta7 splice variant enhances triple negative breast cancer aggressiveness by modulating mitochondrial function via NFkB-SIRT3 axis.
    Title: A novel metadherinΔ7 splice variant enhances triple negative breast cancer aggressiveness by modulating mitochondrial function via NFĸB-SIRT3 axis.
  9. Investigated the therapeutic efficacy of micheliolide (MCL) on renal fibrosis in vivo and in vitro and further investigate the underlying mechanism of metadherin (Mtdh) as a target of MCL in this condition.
    Title: Micheliolide ameliorates renal fibrosis by suppressing the Mtdh/BMP/MAPK pathway.
  10. AEG-1 has a role in regulating macrophage activation; AEG-1 is required in both tumor cells and tumor microenvironment to stimulate hepatocarcinogenesis
    Title: Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NF-kappaB binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular canaliculus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein LYRIC
Names
lysine-rich CEACAM1 co-isolated protein
metastasis adhesion protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357925.1 → NP_001344854.1  protein LYRIC isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks exons in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC149588
    Conserved Domains (1) summary
    pfam15686
    Location:6 → 386
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family

  2. NM_001357926.1 → NP_001344855.1  protein LYRIC isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC149588
    Conserved Domains (1) summary
    pfam15686
    Location:6 → 449
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family

  3. NM_026002.5 → NP_080278.3  protein LYRIC isoform 3

    See identical proteins and their annotated locations for NP_080278.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AC149588
    Consensus CDS
    CCDS27415.1
    UniProtKB/Swiss-Prot
    B2RSG8, Q05CM0, Q3U9F8, Q3UAQ8, Q80WJ7, Q8BN67, Q8CBT9, Q8CDL0, Q8CGI7, Q9D052
    Related
    ENSMUSP00000022865.10, ENSMUST00000022865.17
    Conserved Domains (1) summary
    pfam15686
    Location:6 → 419
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    34082613..34143683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520151.3 → XP_006520214.1  protein LYRIC isoform X2

    Conserved Domains (1) summary
    pfam15686
    Location:6 → 449
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family

  2. XM_017316729.3 → XP_017172218.1  protein LYRIC isoform X4

    Conserved Domains (1) summary
    pfam15686
    Location:6 → 419
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family

  3. XM_006520152.3 → XP_006520215.1  protein LYRIC isoform X7

    UniProtKB/TrEMBL
    F6QHD1
    Related
    ENSMUSP00000130190.3, ENSMUST00000163333.9
    Conserved Domains (1) summary
    pfam15686
    Location:6 → 386
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family

  4. XM_006520149.3 → XP_006520212.1  protein LYRIC isoform X1

    Conserved Domains (1) summary
    pfam15686
    Location:6 → 390
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family

  5. XM_017316731.3 → XP_017172220.1  protein LYRIC isoform X6

    Conserved Domains (1) summary
    pfam15686
    Location:6 → 390
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family

  6. XM_017316728.3 → XP_017172217.1  protein LYRIC isoform X3

    Conserved Domains (1) summary
    pfam15686
    Location:6 → 360
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family

  7. XM_017316730.3 → XP_017172219.1  protein LYRIC isoform X5

    Conserved Domains (1) summary
    pfam15686
    Location:6 → 327
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family

  8. XM_030248710.1 → XP_030104570.1  protein LYRIC isoform X8

    UniProtKB/TrEMBL
    F6ZSG0
    Related
    ENSMUSP00000131814.2, ENSMUST00000169905.2
    Conserved Domains (1) summary
    pfam15686
    Location:12 → 208
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family

  9. XM_036159548.1 → XP_036015441.1  protein LYRIC isoform X9

    UniProtKB/TrEMBL
    F6ZSG0
    Conserved Domains (1) summary
    pfam15686
    Location:12 → 175
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80WJ7.1 GenPept UniProtKB/Swiss-Prot:Q80WJ7

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