Psmd9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmd9provided by MGI
Official Full Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 9provided by MGI
Primary source: MGI:MGI:1914401
See related: Ensembl:ENSMUSG00000029440 AllianceGenome:MGI:1914401
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P27; Bridge-1; 1500011J20Rik; 2610202L11Rik
Summary: Predicted to enable bHLH transcription factor binding activity; protein C-terminus binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including proteasome regulatory particle assembly; regulation of insulin secretion; and type B pancreatic cell apoptotic process. Predicted to be part of proteasome regulatory particle, base subcomplex. Predicted to be active in cytoplasm and nucleus. Is expressed in exoccipital bone; nasal pit; orbito-sphenoid; otocyst; and temporal bone petrous part. Orthologous to human PSMD9 (proteasome 26S subunit, non-ATPase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E18 (RPKM 15.6), liver E14 (RPKM 13.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 62.85 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (123366253..123388189)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (123228190..123250126)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results therefore suggest that proteasomes, particularly p27 subunit, are directly involved in the regulation of melanin biosynthesis in mouse melanoma cells.
Title: Increased level of p27 subunit of proteasomes and its co-localization with tyrosinase in amelanotic melanoma cells indicate its direct role in the regulation of melanin biosynthesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables bHLH transcription factor binding	ISO Inferred from Sequence Orthology more info
enables bHLH transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in proteasome regulatory particle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome regulatory particle assembly	ISO Inferred from Sequence Orthology more info
involved_in type B pancreatic cell apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of proteasome regulatory particle, base subcomplex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 26S proteasome non-ATPase regulatory subunit 9

Names: 26S proteasome regulatory subunit p27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026000.2 → NP_080276.2 26S proteasome non-ATPase regulatory subunit 9

See identical proteins and their annotated locations for NP_080276.2

Status: VALIDATED

Source sequence(s)

BC051930, BY128235

Consensus CDS

CCDS39266.1

UniProtKB/Swiss-Prot

Q3TG66, Q9CR00

UniProtKB/TrEMBL

Q3THC1

Related

ENSMUSP00000098295.5, ENSMUST00000100729.9

Conserved Domains (2) summary

cd00989
Location:128 → 204

PDZ_metalloprotease; PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ ...

cl21454
Location:64 → 151

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins