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Rnf141 ring finger protein 141 [ Mus musculus (house mouse) ]

Gene ID: 67150, updated on 21-Apr-2024

Summary

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Official Symbol
Rnf141provided by MGI
Official Full Name
ring finger protein 141provided by MGI
Primary source
MGI:MGI:1914400
See related
Ensembl:ENSMUSG00000030788 AllianceGenome:MGI:1914400
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZFP36; ZNF230; 2610110L04Rik
Summary
Predicted to enable ubiquitin-protein transferase activity. Acts upstream of or within regulation of transcription, DNA-templated. Predicted to be located in membrane. Is expressed in several structures, including eye; genitourinary system; heart; liver; and lung. Orthologous to human RNF141 (ring finger protein 141). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 5.5), subcutaneous fat pad adult (RPKM 5.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E3; 7 57.87 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (110398676..110443659, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110799469..110844452, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA B430319F04 gene Neighboring gene adenosine monophosphate deaminase 3 Neighboring gene predicted gene, 39069 Neighboring gene STARR-positive B cell enhancer ABC_E2250 Neighboring gene lymphatic vessel endothelial hyaluronan receptor 1 Neighboring gene STARR-seq mESC enhancer starr_19833 Neighboring gene inositol 1,4,5-triphosphate receptor associated 1 Neighboring gene predicted gene 16336

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A new mutant transcript generated in Znf230 exon 2 knockout mice reveals a potential exon structure in the targeting vector sequence. Liu Y, et al. Acta Biochim Biophys Sin (Shanghai), 2013 Feb. PMID 23196134
  2. Expression and localization of the spermatogenesis-related gene, Znf230, in mouse testis and spermatozoa during postnatal development. Song H, et al. BMB Rep, 2008 Sep 30. PMID 18823591
  3. Molecular cloning and characterization of a mouse spermatogenesis-related ring finger gene znf230. Qiu W, et al. Biochem Biophys Res Commun, 2003 Jun 27. PMID 12804569
  4. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In summary, a potential exon structure in the targeting vector sequence involved in the expression of targeting Znf230 gene and disturbed the strategy of this gene-targeting experiment.
    Title: A new mutant transcript generated in Znf230 exon 2 knockout mice reveals a potential exon structure in the targeting vector sequence.
  2. The results indicate that Znf230 may play an important role in mouse spermatogenesis, including spermatogenic cell proliferation and sperm maturation, as well as motility and fertilization.
    Title: Expression and localization of the spermatogenesis-related gene, Znf230, in mouse testis and spermatozoa during postnatal development.
  3. may function as a testis specific transcription factor during mouse spermatogenesis
    Title: Molecular cloning and characterization of a mouse spermatogenesis-related ring finger gene znf230.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein autoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RING finger protein 141
Names
zinc finger protein 230

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418793.1 → NP_001405722.1  RING finger protein 141 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122844, AC184052

  2. NM_001418794.1 → NP_001405723.1  RING finger protein 141 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122844, AC184052
    UniProtKB/TrEMBL
    H3BJB4

  3. NM_001418795.1 → NP_001405724.1  RING finger protein 141 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122844, AC184052
    UniProtKB/TrEMBL
    H3BJB4
    Related
    ENSMUSP00000134917.2, ENSMUST00000177462.8

  4. NM_001418796.1 → NP_001405725.1  RING finger protein 141 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122844, AC184052
    UniProtKB/TrEMBL
    H3BJU0

  5. NM_001418797.1 → NP_001405726.1  RING finger protein 141 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC122844, AC184052

  6. NM_001418798.1 → NP_001405727.1  RING finger protein 141 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC122844, AC184052
    UniProtKB/TrEMBL
    A0A1B0GT51
    Related
    ENSMUSP00000148202.2, ENSMUST00000176716.3

  7. NM_001418799.1 → NP_001405728.1  RING finger protein 141 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC122844, AC184052

  8. NM_001418800.1 → NP_001405729.1  RING finger protein 141 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC122844, AC184052
    UniProtKB/TrEMBL
    H3BJU0
    Related
    ENSMUSP00000135123.2, ENSMUST00000175981.8

  9. NM_001418801.1 → NP_001405730.1  RING finger protein 141 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC122844, AC184052
    UniProtKB/TrEMBL
    H3BJU0

  10. NM_001418802.1 → NP_001405731.1  RING finger protein 141 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122844, AC184052
    UniProtKB/Swiss-Prot
    Q99MB7, Q9D040, Q9D5C4, Q9D9L0

  11. NM_001418803.1 → NP_001405732.1  RING finger protein 141 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122844, AC184052
    UniProtKB/Swiss-Prot
    Q99MB7, Q9D040, Q9D5C4, Q9D9L0
    Related
    ENSMUSP00000102293.4, ENSMUST00000106682.10

  12. NM_001418804.1 → NP_001405733.1  RING finger protein 141 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122844, AC184052
    UniProtKB/Swiss-Prot
    Q99MB7, Q9D040, Q9D5C4, Q9D9L0

  13. NM_025999.4 → NP_080275.2  RING finger protein 141 isoform 1

    See identical proteins and their annotated locations for NP_080275.2

    Status: VALIDATED

    Source sequence(s)
    AC122844, AC184052
    Consensus CDS
    CCDS40086.1
    UniProtKB/Swiss-Prot
    Q99MB7, Q9D040, Q9D5C4, Q9D9L0
    UniProtKB/TrEMBL
    Q3U464
    Related
    ENSMUSP00000134781.2, ENSMUST00000177236.8
    Conserved Domains (1) summary
    cd16545
    Location:154 → 192
    RING-HC_RNF141; RING finger, HC subclass, found in RING finger protein 141 (RNF141) and similar proteins

RNA

  1. NR_184819.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122844, AC184052

  2. NR_184820.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122844, AC184052

  3. NR_184821.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122844, AC184052

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    110398676..110443659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242921.1 → XP_030098781.1  RING finger protein 141 isoform X2

    UniProtKB/TrEMBL
    H3BJB4
    Conserved Domains (1) summary
    cl17238
    Location:154 → 180
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_036153378.1 → XP_036009271.1  RING finger protein 141 isoform X3

    UniProtKB/TrEMBL
    H3BJB4
    Conserved Domains (1) summary
    cl17238
    Location:154 → 180
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RNA

  1. XR_869742.1 RNA Sequence

  2. XR_003946542.1 RNA Sequence

  3. XR_001777995.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MB7.2 GenPept UniProtKB/Swiss-Prot:Q99MB7

Gene LinkOut

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