Herc6 hect domain and RLD 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Herc6provided by MGI
Official Full Name: hect domain and RLD 6provided by MGI
Primary source: MGI:MGI:1914388
See related: Ensembl:ENSMUSG00000029798 AllianceGenome:MGI:1914388
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CEB1; Herc5; 1700121D12Rik; 2510038N07Rik; 4930427L17Rik
Summary: Predicted to enable cyclin binding activity and ubiquitin protein ligase activity. Acts upstream of or within hematopoietic progenitor cell differentiation and response to bacterium. Predicted to be located in cytosol and nucleoplasm. Is expressed in liver. Orthologous to human HERC6 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E18 (RPKM 2.1), cortex adult (RPKM 1.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 27.82 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (57557977..57642121)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (57580992..57665136)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Posttranslational ISGylation of NLRP3 by HERC enzymes facilitates inflammasome activation in models of inflammation.
Title: Posttranslational ISGylation of NLRP3 by HERC enzymes facilitates inflammasome activation in models of inflammation.
The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN.
Title: The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN.
These results suggest that in addition to promoting protein ISGylation, Herc6 has a novel and protein ISGylation-independent function in the male reproductive system.
Title: Murine Herc6 Plays a Critical Role in Protein ISGylation In Vivo and Has an ISGylation-Independent Function in Seminal Vesicles.
Data show that the HerC6 N-terminal RCC1-like domain (RLD) allows ISG15 conjugation.
Title: HERC6 is the main E3 ligase for global ISG15 conjugation in mouse cells.
mHERC6 is essential for endogenous murine ISGylation and thus represents the dominant ISG15 E3 ligase in mice.
Title: mHERC6 is the essential ISG15 E3 ligase in the murine system.
Expression of the Herc5-mediated ubiquitin-like protein ISGylation system can distinctly potentiate interferon-beta-induced antiviral effects against influenza A virus.
Title: Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ISG15--protein ligase Herc6

Names: hect domain and RLD 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025992.2 → NP_080268.1 E3 ISG15--protein ligase Herc6

See identical proteins and their annotated locations for NP_080268.1

Status: VALIDATED

Source sequence(s)

AC127307, AC142212

Consensus CDS

CCDS51796.1

UniProtKB/Swiss-Prot

F2Z461, Q3UEA7, Q9CU70

Related

ENSMUSP00000031817.9, ENSMUST00000031817.10

Conserved Domains (5) summary

smart00119
Location:682 → 999

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:658 → 999

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00415
Location:145 → 195

RCC1; Regulator of chromosome condensation (RCC1) repeat

pfam13540
Location:237 → 266

RCC1_2; Regulator of chromosome condensation (RCC1) repeat

cl02777
Location:570 → 652

chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

57557977..57642121

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_028861.1: Suppressed sequence

Description

NM_028861.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.