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Kbtbd4 kelch repeat and BTB (POZ) domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 67136, updated on 5-Mar-2024

Summary

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Official Symbol
Kbtbd4provided by MGI
Official Full Name
kelch repeat and BTB (POZ) domain containing 4provided by MGI
Primary source
MGI:MGI:1914386
See related
Ensembl:ENSMUSG00000005505 AllianceGenome:MGI:1914386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2510026C23Rik
Summary
Is expressed in several structures, including central nervous system; metanephros; retina; submandibular gland primordium; and trigeminal nerve. Orthologous to human KBTBD4 (kelch repeat and BTB domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 12.4), whole brain E14.5 (RPKM 11.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E1; 2 50.44 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (90735113..90740905)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (90904740..90910561)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 32514 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S3 Neighboring gene predicted gene, 54113 Neighboring gene protein tyrosine phosphatase, mitochondrial 1 Neighboring gene STARR-seq mESC enhancer starr_05099 Neighboring gene CUGBP, Elav-like family member 1 Neighboring gene STARR-seq mESC enhancer starr_05101 Neighboring gene STARR-positive B cell enhancer mm9_chr2:90854051-90854352

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection. Sousa-Nunes R, et al. Genome Res, 2003 Dec. PMID 14613977, Free PMC Article
  2. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  3. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  4. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
kelch repeat and BTB domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311116.2 → NP_001298045.1  kelch repeat and BTB domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001298045.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL672241
    Consensus CDS
    CCDS79820.1
    UniProtKB/Swiss-Prot
    A2AFW3, Q8R179, Q9CQX1
    Related
    ENSMUSP00000107089.2, ENSMUST00000111464.8
    Conserved Domains (6) summary
    smart00225
    Location:62 → 156
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cd14733
    Location:158 → 216
    BACK_like; BTB-And-C-terminal-Kelch (BACK) domain and similar domains
    TIGR03548
    Location:370 → 527
    mutarot_permut; cyclically-permuted mutarotase family protein
    sd00038
    Location:295 → 330
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:55 → 154
    BTB; BTB/POZ domain
    pfam07646
    Location:294 → 330
    Kelch_2; Kelch motif

  2. NM_001361372.2 → NP_001348301.1  kelch repeat and BTB domain-containing protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672241
    Consensus CDS
    CCDS16419.1
    Conserved Domains (4) summary
    PHA03098
    Location:47 → 479
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:279 → 314
    Kelch; KELCH repeat [structural motif]
    cd18272
    Location:13 → 152
    BTB_POZ_KBTBD4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4)
    cd18481
    Location:142 → 229
    BACK_KBTBD4; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4)

  3. NM_025991.5 → NP_080267.1  kelch repeat and BTB domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_080267.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL672241
    Consensus CDS
    CCDS16419.1
    UniProtKB/Swiss-Prot
    Q8R179
    Related
    ENSMUSP00000088179.4, ENSMUST00000090682.4
    Conserved Domains (4) summary
    PHA03098
    Location:47 → 479
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:279 → 314
    Kelch; KELCH repeat [structural motif]
    cd18272
    Location:13 → 152
    BTB_POZ_KBTBD4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4)
    cd18481
    Location:142 → 229
    BACK_KBTBD4; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    90735113..90740905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R179.1 GenPept UniProtKB/Swiss-Prot:Q8R179

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