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Timm21 translocase of inner mitochondrial membrane 21 [ Mus musculus (house mouse) ]

Gene ID: 67105, updated on 5-Mar-2024

Summary

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Official Symbol
Timm21provided by MGI
Official Full Name
translocase of inner mitochondrial membrane 21provided by MGI
Primary source
MGI:MGI:1920595
See related
Ensembl:ENSMUSG00000024645 AllianceGenome:MGI:1920595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700034H14Rik; 2700002I20Rik
Summary
Predicted to be involved in mitochondrial cytochrome c oxidase assembly; mitochondrial respiratory chain complex I assembly; and protein import into mitochondrial matrix. Predicted to act upstream of or within protein transport. Located in mitochondrion. Orthologous to human TIMM21 (translocase of inner mitochondrial membrane 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.4), limb E14.5 (RPKM 10.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E4; 18 57.53 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (84964316..84970168, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (84946191..84951530, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45257 Neighboring gene STARR-positive B cell enhancer ABC_E8728 Neighboring gene predicted gene, 17266 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:85043680-85043998 Neighboring gene STARR-seq mESC enhancer starr_45258 Neighboring gene predicted gene 16146 Neighboring gene STARR-positive B cell enhancer ABC_E11009 Neighboring gene STARR-seq mESC enhancer starr_45265 Neighboring gene cytochrome b5 type A (microsomal) Neighboring gene STARR-seq mESC enhancer starr_45275 Neighboring gene F-box protein 15 Neighboring gene STARR-seq mESC enhancer starr_45276 Neighboring gene STARR-seq mESC enhancer starr_45277 Neighboring gene STARR-seq mESC enhancer starr_45279 Neighboring gene predicted gene, 32291 Neighboring gene predicted gene 7612

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TIM23 mitochondrial import inner membrane translocase complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
mitochondrial import inner membrane translocase subunit Tim21
Names
TIM21-like protein, mitochondrial
tranlocase of inner mitochondrial membrane 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025969.5 → NP_080245.1  mitochondrial import inner membrane translocase subunit Tim21

    See identical proteins and their annotated locations for NP_080245.1

    Status: VALIDATED

    Source sequence(s)
    AC134545
    Consensus CDS
    CCDS29386.1
    UniProtKB/Swiss-Prot
    Q3THX0, Q8CCM6, Q8CE44, Q9CYU8, Q9CZS4
    Related
    ENSMUSP00000025547.3, ENSMUST00000025547.4
    Conserved Domains (1) summary
    pfam08294
    Location:98 → 240
    TIM21

RNA

  1. NR_160856.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC134545

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    84964316..84970168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247094.4 → XP_011245396.1  mitochondrial import inner membrane translocase subunit Tim21 isoform X1

    See identical proteins and their annotated locations for XP_011245396.1

    UniProtKB/Swiss-Prot
    Q8CCM6
    Conserved Domains (1) summary
    cl21648
    Location:98 → 167
    Coa1; Cytochrome oxidase complex assembly protein 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CCM6.2 GenPept UniProtKB/Swiss-Prot:Q8CCM6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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