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Mettl21a methyltransferase 21A, HSPA lysine [ Mus musculus (house mouse) ]

Gene ID: 67099, updated on 11-Apr-2024

Summary

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Official Symbol
Mettl21aprovided by MGI
Official Full Name
methyltransferase 21A, HSPA lysineprovided by MGI
Primary source
MGI:MGI:1914349
See related
Ensembl:ENSMUSG00000025956 AllianceGenome:MGI:1914349
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam119a; 2310038H17Rik
Summary
Predicted to enable ATPase binding activity; Hsp70 protein binding activity; and protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine methylation. Predicted to act upstream of or within methylation. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Orthologous to human METTL21A (methyltransferase 21A, HSPA lysine). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 3.7), limb E14.5 (RPKM 3.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mettl21a in Genome Data Viewer
Location:
1 C2; 1 32.74 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (64645632..64661926, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (64606473..64620466, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36148 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:64578558-64578769 Neighboring gene STARR-positive B cell enhancer ABC_E4317 Neighboring gene STARR-positive B cell enhancer ABC_E2546 Neighboring gene cAMP responsive element binding protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr1:64631759-64632060 Neighboring gene STARR-positive B cell enhancer ABC_E10013 Neighboring gene predicted gene 29152 Neighboring gene RIKEN cDNA 2810408I11 gene Neighboring gene STARR-positive B cell enhancer ABC_E983

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. METTL21A, a Non-Histone Methyltransferase, Is Dispensable for Spermatogenesis and Male Fertility in Mice. Li J, et al. Int J Mol Sci, 2022 Feb 9. PMID 35216057, Free PMC Article
  2. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-lysine methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein methylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein N-lysine methyltransferase METTL21A
Names
family with sequence similarity 119, member A
methyltransferase like 21A
methyltransferase-like protein 21A
protein-lysine methyltransferase METTL21A
NP_001355212.1
NP_001355213.1
NP_080240.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368283.1 → NP_001355212.1  protein N-lysine methyltransferase METTL21A

    Status: VALIDATED

    Source sequence(s)
    AC166336
    Consensus CDS
    CCDS15006.1
    UniProtKB/Swiss-Prot
    Q8R2Y7, Q9CQL0

  2. NM_001368284.1 → NP_001355213.1  protein N-lysine methyltransferase METTL21A

    Status: VALIDATED

    Source sequence(s)
    AC166336
    Consensus CDS
    CCDS15006.1
    UniProtKB/Swiss-Prot
    Q8R2Y7, Q9CQL0
    Related
    ENSMUSP00000109713.3, ENSMUST00000114079.9

  3. NM_025964.4 → NP_080240.1  protein N-lysine methyltransferase METTL21A

    See identical proteins and their annotated locations for NP_080240.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AC166336
    Consensus CDS
    CCDS15006.1
    UniProtKB/Swiss-Prot
    Q8R2Y7, Q9CQL0
    Related
    ENSMUSP00000050424.2, ENSMUST00000053469.2
    Conserved Domains (1) summary
    pfam10294
    Location:25 → 190
    Methyltransf_16; Lysine methyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    64645632..64661926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001785519.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQL0.1 GenPept UniProtKB/Swiss-Prot:Q9CQL0

Gene LinkOut

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