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Trak1 trafficking protein, kinesin binding 1 [ Mus musculus (house mouse) ]

Gene ID: 67095, updated on 5-Mar-2024

Summary

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Official Symbol
Trak1provided by MGI
Official Full Name
trafficking protein, kinesin binding 1provided by MGI
Primary source
MGI:MGI:1914345
See related
Ensembl:ENSMUSG00000032536 AllianceGenome:MGI:1914345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hyrt; mKIAA1042; 2310001H13Rik
Summary
Enables GABA receptor binding activity. Involved in anterograde axonal transport of mitochondrion. Predicted to be located in axonal growth cone; early endosome; and perinuclear region of cytoplasm. Predicted to be active in cytoplasmic vesicle; dendrite; and mitochondrion. Is expressed in several structures, including central nervous system; dorsal root ganglion; liver; spleen; and submandibular gland primordium. Used to study Stiff-Person syndrome. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 68. Orthologous to human TRAK1 (trafficking kinesin protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 26.4), heart adult (RPKM 14.9) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F4; 9 72.41 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121126568..121303985)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (121297502..121474919)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene unc-51-like kinase 4 Neighboring gene STARR-positive B cell enhancer ABC_E3868 Neighboring gene predicted gene, 34735 Neighboring gene VISTA enhancer mm1661 Neighboring gene predicted gene, 34655 Neighboring gene STARR-seq mESC enhancer starr_25526 Neighboring gene STARR-seq mESC enhancer starr_25527 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:121280653-121280762 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:121388759-121388868 Neighboring gene predicted gene, 51661 Neighboring gene predicted gene, 38661 Neighboring gene predicted gene, 47095 Neighboring gene cholecystokinin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking. Webber E, et al. J Mol Biol, 2008 Oct 10. PMID 18675823, Free PMC Article
  2. TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. van Spronsen M, et al. Neuron, 2013 Feb 6. PMID 23395375
  3. Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. Gilbert SL, et al. Nat Genet, 2006 Feb. PMID 16380713
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GABA receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables TPR domain binding ISO
Inferred from Sequence Orthology
more info
  
enables myosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anterograde axonal transport of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anterograde axonal transport of mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axonal transport of mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion distribution IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
trafficking kinesin-binding protein 1
Names
protein Milton

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357968.1 → NP_001344897.1  trafficking kinesin-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115863, AC131660
    UniProtKB/TrEMBL
    Q80TL6
    Conserved Domains (2) summary
    pfam04849
    Location:45 → 302
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:363 → 530
    Milton; Kinesin associated protein

  2. NM_001357969.1 → NP_001344898.1  trafficking kinesin-binding protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC115863, AC131660
    UniProtKB/TrEMBL
    Q80TL6
    Conserved Domains (2) summary
    pfam04849
    Location:1 → 249
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:310 → 477
    Milton; Kinesin associated protein

  3. NM_001357970.1 → NP_001344899.1  trafficking kinesin-binding protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC115863, AC131660
    UniProtKB/TrEMBL
    Q80TL6
    Conserved Domains (2) summary
    pfam04849
    Location:1 → 249
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:310 → 477
    Milton; Kinesin associated protein

  4. NM_001357972.1 → NP_001344901.1  trafficking kinesin-binding protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC115863, AK029123, AK041436, BE957084
    Consensus CDS
    CCDS90685.1
    UniProtKB/TrEMBL
    A0A1B0GRP1, A0A1B0GSQ2
    Related
    ENSMUSP00000148026.2, ENSMUST00000211439.2
    Conserved Domains (2) summary
    pfam04849
    Location:1 → 249
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:310 → 476
    Milton; Kinesin associated protein

  5. NM_001357973.1 → NP_001344902.1  trafficking kinesin-binding protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC115863
    Consensus CDS
    CCDS90684.1
    UniProtKB/TrEMBL
    Q80VE1
    Related
    ENSMUSP00000148092.2, ENSMUST00000210636.2
    Conserved Domains (1) summary
    pfam04849
    Location:49 → 231
    HAP1_N; HAP1 N-terminal conserved region

  6. NM_175114.4 → NP_780323.2  trafficking kinesin-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_780323.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC115863, AC131660
    Consensus CDS
    CCDS40810.1
    UniProtKB/Swiss-Prot
    Q6PD31, Q8BYA3
    UniProtKB/TrEMBL
    Q80TL6
    Related
    ENSMUSP00000044482.7, ENSMUST00000045903.8
    Conserved Domains (4) summary
    pfam04849
    Location:49 → 352
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:421 → 580
    Milton; Kinesin associated protein
    cl12013
    Location:132 → 345
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl21478
    Location:263 → 355
    ATP-synt_B; ATP synthase B/B' CF(0)

RNA

  1. NR_152160.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC115863, AC131660, AK029123, AK041436
    Related
    ENSMUST00000210798.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    121126568..121303985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PD31.1 GenPept UniProtKB/Swiss-Prot:Q6PD31

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