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Trappc6a trafficking protein particle complex 6A [ Mus musculus (house mouse) ]

Gene ID: 67091, updated on 5-Mar-2024

Summary

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Official Symbol
Trappc6aprovided by MGI
Official Full Name
trafficking protein particle complex 6Aprovided by MGI
Primary source
MGI:MGI:1914341
See related
Ensembl:ENSMUSG00000002043 AllianceGenome:MGI:1914341
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mhyp; TRS33; 1810073E21Rik; 4930519D19Rik
Summary
Acts upstream of or within melanosome assembly. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be part of TRAPP complex. Predicted to be active in cis-Golgi network and trans-Golgi network. Orthologous to human TRAPPC6A (trafficking protein particle complex subunit 6A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 87.4), colon adult (RPKM 73.9) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 9.92 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19242595..19250070)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19508665..19516145)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene exocyst complex component 3-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E6520 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 3 Neighboring gene NTPase, KAP family P-loop domain containing 1 Neighboring gene protein phosphatase 1, regulatory subunit 37

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain. Chang JY, et al. Oncotarget, 2015 Feb 28. PMID 25650666, Free PMC Article
  2. Identification of an additional member of the protein-tyrosine-phosphatase family: evidence for alternative splicing in the tyrosine phosphatase domain. Matthews RJ, et al. Proc Natl Acad Sci U S A, 1990 Jun. PMID 2162042, Free PMC Article
  3. A mouse TRAPP-related protein is involved in pigmentation. Gwynn B, et al. Genomics, 2006 Aug. PMID 16697553
  4. TRAPP Complexes in Secretion and Autophagy. Kim JJ, et al. Front Cell Dev Biol, 2016. PMID 27066478, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC117907

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in COPII vesicle coating NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in Golgi vesicle transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle tethering NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of TRAPP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TRAPPIII protein complex NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
trafficking protein particle complex subunit 6A
Names
TRAPP complex subunit 6A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331181.1 → NP_001318110.1  trafficking protein particle complex subunit 6A isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) has a longer, distinct C-terminus than isoform 1.
    Source sequence(s)
    AC149052
    Consensus CDS
    CCDS90174.1
    UniProtKB/Swiss-Prot
    Q78XR0
    Related
    ENSMUSP00000104095.2, ENSMUST00000108455.8

  2. NM_025960.4 → NP_080236.2  trafficking protein particle complex subunit 6A isoform a

    See identical proteins and their annotated locations for NP_080236.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a).
    Source sequence(s)
    AC149052, AK007965
    Consensus CDS
    CCDS20905.1
    UniProtKB/Swiss-Prot
    Q3KQP0, Q78XR0, Q8C2C8, Q9CQ27, Q9D8H6
    Related
    ENSMUSP00000002112.9, ENSMUST00000002112.15
    Conserved Domains (1) summary
    cd14944
    Location:3 → 157
    TRAPPC6A_Trs33; Trs33 subunit of the TRAPP complex

RNA

  1. NR_138582.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149052
    Related
    ENSMUST00000147114.2

  2. NR_138583.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149052
    Related
    ENSMUST00000136873.8

  3. NR_138584.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149052

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19242595..19250070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242919.2 → XP_030098779.1  trafficking protein particle complex subunit 6A isoform X1

    Conserved Domains (1) summary
    cd14944
    Location:3 → 129
    TRAPPC6A_Trs33; Trs33 subunit of the TRAPP complex
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q78XR0.1 GenPept UniProtKB/Swiss-Prot:Q78XR0

Gene LinkOut

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