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Cand2 cullin associated and neddylation dissociated 2 (putative) [ Mus musculus (house mouse) ]

Gene ID: 67088, updated on 11-Apr-2024

Summary

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Official Symbol
Cand2provided by MGI
Official Full Name
cullin associated and neddylation dissociated 2 (putative)provided by MGI
Primary source
MGI:MGI:1914338
See related
Ensembl:ENSMUSG00000030319 AllianceGenome:MGI:1914338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tp120b; mKIAA0667; 2210404G23Rik
Summary
Enables TBP-class protein binding activity. Predicted to be involved in SCF complex assembly and protein ubiquitination. Located in nucleus. Is expressed in several structures, including limb bud; musculature; and nervous system. Orthologous to human CAND2 (cullin associated and neddylation dissociated 2 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 24.2), heart adult (RPKM 22.0) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Cand2 in Genome Data Viewer
Location:
6 E3; 6 53.71 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (115751518..115782516)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (115774557..115805555)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 40 Neighboring gene STARR-seq mESC enhancer starr_17094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115724212-115724399 Neighboring gene predicted gene, 44180 Neighboring gene microRNA 7660 Neighboring gene STARR-positive B cell enhancer ABC_E4857 Neighboring gene small nucleolar RNA, H/ACA box 7A Neighboring gene ribosomal protein L32 Neighboring gene EF-hand calcium binding domain 12 Neighboring gene STARR-positive B cell enhancer ABC_E2201

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Detecting epistasis within chromatin regulatory circuitry reveals CAND2 as a novel susceptibility gene for obesity. Dong SS, et al. Int J Obes (Lond), 2019 Mar. PMID 29717274, Free PMC Article
  2. TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3. Aoki T, et al. Biochem Biophys Res Commun, 2002 Sep 6. PMID 12207886
  3. TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation. Shiraishi S, et al. J Biol Chem, 2007 Mar 23. PMID 17242400
  4. TIP120B: a novel TIP120-family protein that is expressed specifically in muscle tissues. Aoki T, et al. Biochem Biophys Res Commun, 1999 Aug 11. PMID 10441524
  5. Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Ling KH, et al. Genome Biol, 2009. PMID 19799774, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CAND2 inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation
    Title: TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables TBP-class protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in SCF complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cullin-associated NEDD8-dissociated protein 2
Names
TBP-interacting protein 120B
TBP-interacting protein b
TBP-interacting protein of 120 kDa B
cullin-associated and neddylation-dissociated protein 2
p120 CAND2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025958.2 → NP_080234.2  cullin-associated NEDD8-dissociated protein 2

    See identical proteins and their annotated locations for NP_080234.2

    Status: VALIDATED

    Source sequence(s)
    BC056365, BC058338, BP761509, BY553771, CJ299742
    Consensus CDS
    CCDS20442.1
    UniProtKB/Swiss-Prot
    Q6PHT7, Q6ZQ73
    UniProtKB/TrEMBL
    Q3UM57
    Related
    ENSMUSP00000075377.6, ENSMUST00000075995.7
    Conserved Domains (3) summary
    pfam08623
    Location:1057 → 1206
    TIP120; TATA-binding protein interacting (TIP20)
    pfam13513
    Location:150 → 202
    HEAT_EZ; HEAT-like repeat
    sd00044
    Location:864 → 886
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    115751518..115782516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255552.2 → XP_030111412.1  cullin-associated NEDD8-dissociated protein 2 isoform X1

    Conserved Domains (4) summary
    COG1413
    Location:392 → 558
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:391 → 413
    HEAT; HEAT repeat [structural motif]
    pfam08623
    Location:584 → 733
    TIP120; TATA-binding protein interacting (TIP20)
    pfam13513
    Location:367 → 414
    HEAT_EZ; HEAT-like repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQ73.2 GenPept UniProtKB/Swiss-Prot:Q6ZQ73

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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